C[C@@]1(CCCN1)c2[nH]c3cccc(c3n2)C(=O)N EX-A001
c1ccc2c(c1)c(n[nH]c2=O)Cc3ccc(c(c3)C(=O)N4CCN(CC4)C(=O)C5CC5)F EX-A002
COc1c(cc(cn1)c2ccc3c(c2)c(ccn3)c4ccnnc4)NS(=O)(=O)c5ccc(cc5F)F EX-A003
CCOc1ccn(c(=O)c1C(=O)Nc2ccc(c(c2)F)Oc3ccnc(c3Cl)N)c4ccc(cc4)F EX-A004
CCOc1ccc(cc1)Cc2cc(ccc2Cl)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O EX-A005
CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)c5cnccn5 EX-A006
CNC(=O)c1cc(ccn1)COc2c3c(cco3)c(nn2)Nc4ccc(cc4)Cl EX-A007
CCc1cc(c(cc1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)Nc4nccc(n4)c5c(nc6n5cccc6)c7ccc(c(c7)C(=O)Nc8c(cccc8F)F)OC EX-A008
Cc1cccc(n1)c2c(c3n(n2)CCC3)c4ccnc5c4cc(cc5)C(=O)N EX-A009
Cc1ccc2c(=O)c3c(oc2c1C)C(=CCC3=O)CC(=O)O EX-A010
Cc1cc2c([nH]1)ccc(c2F)Oc3c4c(c(cn4ncn3)OC[C@@H](C)O)C EX-A011
Cc1cc2c([nH]1)ccc(c2F)Oc3c4c(c(cn4ncn3)OC[C@@H](C)OC(=O)[C@H](C)N)C EX-A012
c1cc(c(c(c1)F)N(c2ccc(c(n2)c3ccc(cc3F)F)C(=O)N)C(=O)N)F EX-A013
Cc1ccc(c(c1)NC(=O)Nc2ccc(cc2)c3cccc4c3c(n[nH]4)N)F EX-A014
CN1CCN(CC1)c2c(cc3c4c2OCN(n4cc(c3=O)C(=O)O)C)F EX-A015
COc1c2c(cc(c1N3C[C@@H]4CCCN[C@@H]4C3)F)c(=O)c(cn2C5CC5)C(=O)O EX-A016
CC(C)(Cc1ccc2ccccc2c1)NC[C@H](COc3cccc(c3C#N)Cl)O EX-A017
CNCc1ccc(cc1)c2c3c4c(cc(cc4[nH]2)F)C(=O)NCC3.OP(=O)(O)O EX-A018
Cc1c([nH]c(c1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/c5cc(ccc5NC4=O)S(=O)(=O)Cc6c(cccc6Cl)Cl EX-A019
Cn1cnc2c1cc(c(c2F)Nc3ccc(cc3Cl)Br)C(=O)NOCCO EX-A020
CCn1cc(c(n1)c2ccc(cc2)NC(=O)N(C)C)c3ccnc4c3cc([nH]4)c5cccc(c5)CN(C)C EX-A021
Cc1c2c(c(n(c1=O)C)Nc3ccc(cc3F)I)c(=O)n(c(=O)n2c4cccc(c4)NC(=O)C)C5CC5 EX-A022
Cc1c2cc(ccc2[nH]n1)c3cc(cnc3)OC[C@H](Cc4ccccc4)N EX-A023
COc1cccc(c1C2=NCc3cnc(nc3-c4c2cc(cc4)Cl)Nc5ccc(c(c5)OC)C(=O)O)F EX-A024
Cc1c2cnc(nc2n(c(=O)c1C(=O)C)C3CCCC3)Nc4ccc(cn4)N5CCNCC5.Cl EX-A025
c1cc2c(cc1/C=C/3\C(=O)NC(=O)S3)nccn2 EX-A026
C[C@@H](C(=O)N[C@H]1c2ccccc2-c3ccccc3N(C1=O)C)NC(=O)Cc4cc(cc(c4)F)F EX-A027
CN(C)C1CCN(CC1)C(=O)c2ccc(cc2)NC(=O)Nc3ccc(cc3)c4nc(nc(n4)N5CCOCC5)N6CCOCC6 EX-A028
c1cc(c(cc1NC(=O)c2ccc(cn2)F)[C@]34COC[C@H]3CSC(=N4)N)F EX-A029
COc1cc2c(cc1NC(=O)/C=C/CN3CCCCC3)c(ncn2)Nc4ccc(c(c4)Cl)F EX-A030
CCn1c2c(cnc(c2nc1c3c(non3)N)C#CC(C)(C)O)OC[C@H]4CCCNC4 EX-A031
Cc1nc(nc2c1cc(c(=O)n2[C@H]3CC[C@@H](CC3)OCCO)c4cnc(cc4)OC)N EX-A032
c1ccc(c(c1)c2cn3c(csc3n2)CN4CCNCC4)NC(=O)c5cnc6ccccc6n5 EX-A033
CC(C)n1c2c(c(n1)c3cc4cc(ccc4[nH]3)O)c(ncn2)N EX-A034
CCc1c(cc(c(c1CC(=O)N(CCOC)CCOC)C(=O)c2ccc(c(c2)OC)OCCN3CCOCC3)O)O EX-A035
CNC(=O)CN1CCC(CC1)Oc2cc3c(cc2OC)ncnc3Nc4cccc(c4F)Cl EX-A036
c1cc(cc(c1)NC(=O)c2ccc(nc2)N)c3nc4c5cccnc5oc4c(n3)N6CCOCC6 EX-A037
c1ccc(c(c1)N)NC(=O)c2ccc(cc2)CNC(=O)OCc3cccnc3 EX-A038
c1cc(cc(c1)O)c2nc3c4cccnc4oc3c(n2)N5CCOCC5 EX-A039
CCn1c2c(c(nc(n2)c3ccc(cc3)NC(=O)Nc4ccc(cc4)C(=O)N5CCN(CC5)C)N6CCOCC6)nn1 EX-A040
Cc1c(sc2c1nc(nc2N3CCOCC3)c4cnc(nc4)N)CN5CCN(CC5)C(=O)[C@H](C)O EX-A041
CC(C)c1nc(on1)N2CCC(CC2)COc3ccc(nc3)c4ccc(cc4)S(=O)(=O)C EX-A042
c1cc(c(cc1Cl)Cl)C(=O)[N-]S(=O)(=O)c2ccc(s2)Br.[Na+] EX-A043
C[C@H]1COCCN1c2c3ccc(nc3nc(n2)N4CCOC[C@@H]4C)c5ccc(c(c5)CO)OC EX-A044
C[C@@H]1CN(C[C@@H](O1)C)c2nc3c(ccc(n3)c4ccc(c(c4)CO)OC)c(n2)N5CCOCC5 EX-A045
CC1(C(=O)N(C(=S)N1c2ccc(c(c2)F)C(=O)NC)c3ccc(c(c3)C(F)(F)F)C#N)C EX-A046
C=CC(=O)Nc1ccc2c(c1)c(ncn2)Nc3ccc(c(c3)Cl)OCc4cccc(c4)F EX-A047
COc1ccc(cc1)n2c3c(c(n2)C(=O)N)CCN(C3=O)c4ccc(cc4)N5CCCCC5=O EX-A048
c1ccc(c(c1)N)NC(=O)c2ccc(cc2)CNc3nccc(n3)c4cccnc4 EX-A049
COc1cc2c(ccnc2cc1OCCCN3CCOCC3)Oc4ccc(cc4F)N(c5ccc(cc5)F)C(=O)C6(CC6)C(=O)N EX-A050
Cn1cc(nc1)c2cc3c(s2)c(ccn3)Oc4ccc(cc4F)NC(=S)NC(=O)Cc5ccccc5 EX-A051
CC[C@H](CO)Nc1nc(c2c(n1)n(cn2)C(C)C)NCc3ccccc3 EX-A052
CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)c4ccc(cc4)Cl)F EX-A053
CC(C)(C)c1cnc(o1)CSc2cnc(s2)NC(=O)C3CCNCC3 EX-A054
CC1(CCC(=C(C1)CN2CCN(CC2)c3ccc(cc3)C(=O)NS(=O)(=O)c4ccc(c(c4)S(=O)(=O)C(F)(F)F)N[C@H](CCN5CCOCC5)CSc6ccccc6)c7ccc(cc7)Cl)C EX-A055
CN(C)CC[C@H](CSc1ccccc1)Nc2ccc(cc2[N+](=O)[O-])S(=O)(=O)NC(=O)c3ccc(cc3)N4CCN(CC4)Cc5ccccc5c6ccc(cc6)Cl EX-A056
CCN1CCN(CC1)c2ccc(cc2)Nc3cc(ncn3)N(C)C(=O)Nc4c(c(cc(c4Cl)OC)OC)Cl EX-A057
CNC(=O)c1cc(ccn1)Oc2ccc(c(c2)F)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl EX-A058
c1cc(c(cc1C(=O)Nc2c(cncc2Cl)Cl)OCC3CC3)OC(F)F EX-A059
c1cc2cnccc2c(c1)S(=O)(=O)N3CCCNCC3.Cl.Cl EX-A060
CCOc1cc2c(cc1NC(=O)/C=C/CN(C)C)c(c(cn2)C#N)Nc3ccc(c(c3)Cl)F EX-A061
CCOc1cc2c(cc1NC(=O)/C=C/CN(C)C)c(c(cn2)C#N)Nc3ccc(c(c3)Cl)OCc4ccccn4 EX-A062
Cc1ccc(cc1Nc2nccc(n2)c3cccnc3)NC(=O)c4ccc(cc4)CN5CCN(CC5)C EX-A063
COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C.Cl EX-A064
CN(C)C/C=C/C(=O)Nc1cc2c(cc1O[C@H]3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F EX-A065
C=CC(=O)N1CCC[C@H](C1)n2c3c(c(n2)c4ccc(cc4)Oc5ccccc5)c(ncn3)N EX-A066
Cc1ccc(cc1C#Cc2cnc3n2nccc3)C(=O)Nc4ccc(c(c4)C(F)(F)F)CN5CCN(CC5)C EX-A067
Cc1cc2c(c(c(c(c2C(C)C)O)O)C=O)c(c1c3c(cc4c(c3O)c(c(c(c4C(C)C)O)O)C=O)C)O EX-A068
Cc1ncc(n1C(C)C)c2ccnc(n2)Nc3ccc(cc3)S(=O)(=O)C EX-A069
c1cc(cc(c1)Cl)Nc2c3ccncc3c4ccc(cc4n2)C(=O)O EX-A070
c1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6 EX-A071
Cn1c2ccc(cc2nc1Nc3ccc(cc3)C(F)(F)F)Oc4ccnc(c4)c5[nH]c(cn5)C(F)(F)F EX-A072
c1ccc(cc1)c2cccc3c2oc(cc3=O)N4CCOCC4 EX-A073
c1ccc2c(c1)Sc3cccc(c3S2)c4cc(=O)cc(o4)N5CCOCC5 EX-A074
COc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)N(c4ccc(cc4)F)C(=O)C5(CC5)C(=O)N EX-A075
CC#CCn1c2c(nc1N3CCC[C@H](C3)N)n(c(=O)n(c2=O)Cc4nc(c5ccccc5n4)C)C EX-A076
c1cc(ccc1C(=O)C2CC2)OCCCc3c[nH]cn3 EX-A077
C=CC(=O)Nc1cc2c(cc1OCCCN3CCOCC3)ncnc2Nc4ccc(c(c4)Cl)F EX-A078
CCN(c1ccccc1)C(=O)c2c(c3c(cccc3Cl)n(c2=O)C)O EX-A079
Cc1ccc(cc1Nc2nc(cs2)c3cccnc3)NC(=O)c4ccc(cc4)CN5CCN(CC5)C EX-A080
CC[C@@H]1C[C@@H](c2cc(ccc2N1C(=O)OCC)C(F)(F)F)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)OC EX-A081
Cc1c2c(nc(n1)C)N(C(=O)CC2)Cc3ccc(cc3)c4ccccc4c5n[nH]nn5 EX-A082
COc1cc(cc(c1)OC)NC(=O)c2ccc(o2)c3ccc(cc3)Cl EX-A083
CCc1ccc(cc1)OCc2ccccc2C(=O)Nc3ccc4c(c3)c(cc(n4)C)N.Cl EX-A084
c1cc(cnc1)NC(=O)CCCCCCC(=O)NO EX-A085
COc1cc2c(cc1OC)ncnc2n3c(nc(n3)c4ccccn4)N EX-A086
CCCP(=O)(CCC)c1ccc(cc1)Nc2c3c(nc(n2)C4CCCC4)n(cn3)CCc5cccc(c5)O EX-A087
CC(C)(CC(=O)NCCn1ccc2c1c(ncn2)Nc3ccc(c(c3)Cl)Oc4cccc(c4)C(F)(F)F)O EX-A088
CNC(=O)c1ccc(cc1F)N2C(=S)N(C(=O)C23CCC3)c4cc(c(nc4)C#N)C(F)(F)F EX-A089
Cc1c(c2cc(ccc2n1CC(=O)O)F)Cc3ccc4ccccc4n3 EX-A090
c1ccc(cc1)C(c2ccccc2)OC3CCN(CC3)CCCc4[nH]nnn4 EX-A091
CCC(CC)CC1(CCCCC1)C(=O)Nc2ccccc2SC(=O)C(C)C EX-A092
c1cc(nc(c1)C[C@]2(CC[C@H](CC2)Oc3c(c(ccc3)Cl)F)C(=O)O)Nc4sccn4 EX-A093
C[C@]1(CCSC(=N1)N)c2cc(c(cc2F)F)c3cncnc3 EX-A094
Cc1c(nc(n1c2ccc(cc2)OC(F)(F)F)C)C#Cc3ccnc(c3)Cl EX-A095
C[C@H](c1c(ccc(c1Cl)F)Cl)Oc2cc(cnc2N)c3cnn(c3)C4CCNCC4 EX-A096
CNCc1cc(n(c1)S(=O)(=O)c2cccnc2)c3ccccc3F.C(=C/C(=O)O)\C(=O)O EX-A097
CCCc1c2c(cc3c1oc(cc3=O)C(=O)O)c(=O)cc(n2CC)C(=O)O EX-A098
c1ccc(cc1)Cn2c3ccccc3c(c(c2=O)C(=O)NCC(=O)O)O EX-A099
c1cc(cc(c1)C(=O)N)c2cc(ncn2)Nc3ccc(cc3)OC(F)(F)F EX-A100
CC(=O)Nc1ccc(cc1)/C=N/NC(=S)N EX-A101
c1cc(c(cc1I)F)Nc2c(ccc(c2F)F)C(=O)NOC[C@@H](CO)O EX-A102
CC1(C(=O)Nc2c(ccc(n2)Nc3c(cnc(n3)Nc4cc(c(c(c4)OC)OC)OC)F)O1)C EX-A103
C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c3ccccc3)c4ccccc4)C(=O)CC(C)C)NC EX-A104
COc1ccc(c(c1C(=O)c2cnc(nc2N)NC3CCN(CC3)S(=O)(=O)C)F)F EX-A105
C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4c5cccnc5)C)O EX-A106
CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC=C4c5cccnc5)C)C EX-A107
CC1(C(=O)N(c2c(ccc(n2)Nc3c(cnc(n3)Nc4cc(c(c(c4)OC)OC)OC)F)O1)COP(=O)(O)O)C EX-A108
Cn1c(=O)n(c(=O)s1)Cc2ccccc2 EX-A109
COc1cc(ccc1Cl)NC(=O)c2ccccn2 EX-A110
c1cc(cc(c1)C(F)(F)F)/C=C\2/C(=O)NC(=O)S2 EX-A111
c1ccc2c(c1)cccc2CC3c4cc(c(cc4CCN3)O)O.O.Br EX-A112
c1cn(cn1)c2cc3c(cc2[N+](=O)[O-])[nH]c(=O)c(=O)[nH]3.Cl EX-A113
c1ccc(cc1)Cn2cc(c3c2ccc(c3)c4ccc(cc4)OC(F)(F)F)C(=O)C(=O)O EX-A114
Cc1cc(c(c(c1)C)Nc2ccnc(n2)Nc3ccc(cc3)C#N)C EX-A115
c1ccnc(c1)NCc2ccc(cc2)CNc3ccccn3 EX-A116
Cc1ccc(cc1)c2csc3c2c(ncn3)SCCC(=O)O EX-A117
c1ccc(cc1)CNC(=O)/C(=C/c2ccc(c(c2)O)O)/C#N EX-A118
COc1ccc(cc1NS(=O)(=O)c2cc(cc(c2O)Cl)Cl)c3ccccc3 EX-A119
COc1ccc2c(c1)cc([nH]2)C(=O)c3ccccc3 EX-A120
CCN(CC)c1ccc(cc1)/C=N/NC(=O)c2ccc(cc2)O EX-A121
c1ccnc(c1)c2c(c[nH]n2)c3ccnc(c3)c4ccc(cc4)C(=O)NC5CCOCC5 EX-A122
CC(C)(C)c1[nH]c2c3cc[nH]c(=O)c3c4cc(ccc4c2n1)F EX-A123
CC(CCc1ccccn1)(CCc2ccccn2)C(=O)c3ccccc3 EX-A124
CCC1(Cc2ccccc2O1)c3[nH]ccn3 EX-A125
c1ccc(c(c1)NC(=O)c2cnc3n2cc(cc3)C4CCNCC4)Cl.C(=O)(C(=O)O)O EX-A126
CC(C)c1ccc2c(c1)c(c(n2Cc3ccc(cc3)Cl)CC(C)(C)C(=O)O)SC(C)(C)C EX-A127
C[Si](C)(C)c1cc(cc(c1)[Si](C)(C)C)C(=O)Nc2ccc(cc2)C(=O)O EX-A128
Cn1cnc(c-2ncnc12)N EX-A130
CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc2nncs2 EX-A131
CC(C)(C(=O)O)Sc1ccc(cc1)CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3 EX-A132
c1ccc2c(c1)c(ccn2)c3c[nH]nc3c4ccccn4 EX-A133
CS(=O)c1ccc(cc1)c2[nH]c(c(n2)c3ccc(cc3)F)c4ccncc4 EX-A134
Cc1cc(c(cc1O)Nc2c3ccc(cc3ncn2)OCc4ccccc4)F.Cl EX-A135
COc1cc2c(cc1OC)ncnc2Nc3ccc(cc3F)Cl.Cl EX-A136
c1cc2c(cc1C(=O)CCN3CCN(CC3)C(=O)OCc4cc(cc(c4)Cl)Cl)oc(=O)[nH]2 EX-A137
c1cc(sc1CO)c2ccc(o2)c3ccc(s3)CO EX-A138
c1ccc(cc1)N(c2ccccc2)c3ncc(cn3)C(=O)NCCCCCCC(=O)NO EX-A139
CC(C)S(=O)(=O)c1ccccc1Nc2ncnc(n2)Nc3ccc(cc3OC)N4CCC(CC4)N5CCN(CC5)C EX-A140
Cn1cc(cn1)c2cnn3c2nc(c(c3N)Br)[C@@H]4CCCNC4 EX-A141
CCNC1(CCN(CC1)c2c3c(ncn2)n(c(n3)c4ccccc4Cl)c5ccc(cc5)Cl)C(=O)N.Cl EX-A142
COc1c2[nH]c(cc2ccc1)c3nc(n4c3c(ncn4)N)[C@H]5CC[C@@H](CC5)C(=O)O EX-A143
c1ccnc(c1)c2c(nc([nH]2)c3ccc(cc3)C(=O)N)c4ccc5c(c4)OCO5 EX-A144
CC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C EX-A146
c1ccc2c(c1)C(=O)C(=O)N2Cc3ccc(c(c3)Cl)Cl EX-A147
CCOC(=O)C1=C(Oc2ccc(cc2C1C(C#N)C(=O)OCC)Br)N EX-A148
c1cc(cc(c1)C(F)(F)F)/C=C/2\C(=O)NC(=O)S2 EX-A149
c1c(c(nc(=O)n1[C@@H]2CS[C@@H](O2)CO)N)F EX-A150
c1cc(cc(c1)N)c2cc3c([nH]2)ncnc3Oc4cccc(c4)O EX-A151
c1ccc(c(c1)NS(=O)(=O)c2ccc(cc2Cl)NC(=O)c3ccccn3)Cl EX-A152
CCc1c(c2c(n1Cc3ccccc3)cccc2OCC(=O)O)C(=O)C(=O)N EX-A153
CC(C)(C(=O)N[C@H](Cc1c[nH]c2c1cccc2)C(=O)N3CCC[C@](C3)(Cc4ccccc4)C(=O)N(C)N(C)C)N EX-A154
C[C@H]1COCCN1c2c3ccc(nc3nc(n2)N4CCOC[C@@H]4C)c5cccc(c5)C(=O)NC EX-A155
Cn1c(ccn1)c2c3ccccc3c(nn2)N4CCC(CC4)N(C)C(=O)c5ccc(cc5C(F)(F)F)F EX-A156
c1cc(ccc1[C@H]2[C@H]3CCC[C@H]3c4cc(ccc4O2)O)O EX-A157
c1cc(ccc1[C@]2(C[C@H]2C3CCCCC3)C(=O)Nc4ncc(s4)SCCN5CCCC5)S(=O)(=O)C6CC6 EX-A158
CNC(=O)c1ccc2cc(ccc2c1)[C@]3(CCn4c3cnc4)O EX-A159
Cc1ccc(cc1Nc2c3cnn(c3nc(n2)c4cccnc4)C)C(=O)Nc5cccc(c5)C(F)(F)F EX-A160
CC(=O)[C@@]1(Cc2c(c(c3c(c2O)C(=O)c4ccccc4C3=O)O)[C@H](C1)O[C@H]5C[C@@H]([C@@H](CO5)O)O)N EX-A161
CC(C)OC(=O)C1=CN(CC(c2c1[nH]c3c2cccc3)(C)C)C(=O)c4ccc(c(c4)F)F EX-A162
CCCCCCOC(=O)N/N=C/c1ccc(cc1)NCc2nc3cc(ccc3n2C)C(=O)N(CCC(=O)OCC)c4ccccn4.CS(=O)(=O)O EX-A164
CCc1c(c(n(n1)CCO)CC)Oc2cc(cc(c2)C#N)C#N EX-A165
CC(C)c1c(c(c(n1CC[C@H](C[C@H](CC(=O)[O-])O)O)c2ccc(cc2)F)c3ccccc3)C(=O)Nc4ccccc4.[Na+] EX-A166
CS(=O)(=O)N1CCN(CC1)Cc2cc3c(s2)c(nc(n3)c4cccc5c4cn[nH]5)N6CCOCC6 EX-A167
CC1(CCC(=C(C1)c2ccc(cc2)Cl)CN3CCN(CC3)c4ccc(c(c4)Oc5cc6cc[nH]c6nc5)C(=O)NS(=O)(=O)c7ccc(c(c7)[N+](=O)[O-])NCC8CCOCC8)C EX-A168
Cc1c(c2ccccc2[nH]1)CCNCc3ccc(cc3)/C=C/C(=O)NO EX-A169
Cc1cnc(nc1Nc2cccc(c2)S(=O)(=O)NC(C)(C)C)Nc3ccc(cc3)OCCN4CCCC4 EX-A170
Cc1ccccc1C(C(=O)NC2CCCCC2)N(c3cccc(c3)F)C(=O)Cn4ccnc4C EX-A171
CN1C[C@H]2CC(C[C@H]2C1)COc3cc4c(cc3OC)c(ncn4)Nc5ccc(c(c5F)Cl)Cl EX-A172
CCC1=C[C@H]2C[C@]3([C@@H]1[N@@](C2)CCc4c3[nH]c5c4cccc5)C(=O)OC.OS(=O)(=O)O EX-A173
c1cc2c(cc1C#N)c(c[nH]2)CCCCN3CCN(CC3)c4ccc5c(c4)cc(o5)C(=O)N EX-A174
Cc1ccc(cc1)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)(F)F EX-A175
Cc1c(ccnc1CS(=O)c2[n-]c3ccccc3n2)OCCCOC.[Na+] EX-A176
c1ccc(cc1)C(c2ccccc2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc3ccc(c(c3)[N+](=O)[O-])F EX-A177
Cc1ccc(nc1c2cccc(c2)C(=O)O)NC(=O)C3(CC3)c4ccc5c(c4)OC(O5)(F)F EX-A178
c1c(c(nc(c1SC#N)N)N)SC#N EX-A179
c1ccc(cc1)NS(=O)(=O)c2cccc(c2)/C=C/C(=O)NO EX-A180
c1cc(cc(c1)Cl)NC(=O)Nc2ncc(s2)CCNc3c4c(ccs4)ncn3 EX-A181
c1ccc(cc1)Oc2ccc(cc2)CCNc3c4cc(ccc4ncn3)N EX-A182
Cc1c([nH]c(c1C(=O)N2CCN(CC2)C)C)/C=C\3/c4cc(ccc4NC3=O)S(=O)(=O)N(C)c5cccc(c5)Cl EX-A183
c1cc(c2c(c1)nc([nH]2)c3ccc(cc3F)[C@@H]4CCCN4)C(=O)N EX-A184
CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(c4C(=O)C3=C([C@@]2(C(=O)C(=C1O)C(=O)N)O)O)O)CNCOC.Cl EX-A185
CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)Cl)F EX-A186
Cc1cc(c(cc1C2CCNCC2)OC(C)C)Nc3ncc(c(n3)Nc4ccccc4S(=O)(=O)C(C)C)Cl EX-A187
c1ccc(cc1)NNC(=O)c2ccncc2 EX-A188
c1c(c(cnc1N)c2cc(nc(n2)N3CCOCC3)N4CCOCC4)C(F)(F)F EX-A189
CCCC(C)NC(=O)c1ccc(c(c1)Cl)Cl EX-A190
C[C@]12CC[C@@H](CC1CCC3C2CC[C@]4([C@@]3(CC[C@@]4(C5=CC(=O)OC5)O)O)C)O EX-A191
C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@]4(c5ccoc5)O)O)C)O EX-A192
c1ccc(cc1)Nc2cc(ccc2C(=O)N3CCC(CC3)N4CCCC4)C(=O)N5CCC(CC5)N6CCCC6 EX-A193
Cc1cccc(n1)C#Cc2ccccc2.Cl EX-A194
CCCCOc1ccc(cc1)C(=O)Nc2ccc(cc2F)F EX-A195
Cc1ccc(cc1)S(=O)(=O)Nc2c(nc3ccccc3n2)Nc4ccc5c(c4)nsn5 EX-A196
CCN(CC)CCCCNc1ncc2cc(c(nc2n1)NC(=O)NC(C)(C)C)c3cc(cc(c3)OC)OC EX-A197
c1nc2c(n1C3C[C@@H]([C@H](O3)CO)O)N=CNC[C@H]2O EX-A198
Cc1c(c(ncn1)C)C(=O)N2CCC(CC2)(C)N3CCN([C@H](C3)C)[C@@H](COC)c4ccc(cc4)C(F)(F)F.C(C(C(=O)O)O)C(=O)O EX-A199
Cc1nnc(n1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](c4ccccc4)NC(=O)C5CCC(CC5)(F)F)C(C)C EX-A200
c1cc2c(cc1CN3CCOCC3)nc([nH]2)c4c(c[nH]n4)NC(=O)NC5CC5 EX-A201
CC(C1=C2[C@](CC1=O)(CC[C@@]3([C@@H]2CC[C@H]4[C@]3(CCC5[C@@]4(CC[C@@H]([C@]5(C)C)OC(=O)CC(C(=O)O)(C)C)C)C)C)[C@@H](O)CN(Cc6ccc(cc6)Cl)CCN(C)C)C EX-A202
Cc1cc(cc(c1c2cccc(c2)COc3ccc4c(c3)OC[C@H]4CC(=O)O)C)OCCCS(=O)(=O)C EX-A203
C[C@@H]1CCN(C[C@@H]1N(C)c2c3cc[nH]c3ncn2)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O EX-A204
C[C@@H]1CCN(C[C@@H]1N(C)c2c3cc[nH]c3ncn2)C(=O)CC#N EX-A205
c1cc(ccc1N2CCOCC2=O)N3C[C@@H](OC3=O)CNC(=O)c4ccc(s4)Cl EX-A206
c1cc(c(cc1N2C(=O)C(=C(C2=O)Cl)N3CCOCC3)Cl)Cl EX-A207
c1cc(c(cc1C(F)(F)F)NC(=O)c2ccncc2)N3CCCCC3 EX-A208
c1cc(cc(c1)F)N(Cc2cc(c(c(c2)F)F)F)C(=O)O[C@H]3CN4CCC3CC4 EX-A209
CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4cccc(c4C(=O)C3=C([C@@]2(C(=O)C(=C1O)C(=O)N)O)O)O EX-A210
Cc1ccc(c(c1)C(=O)N2CCN(CC[C@H]2C)c3nc4cc(ccc4o3)Cl)n5nccn5 EX-A211
C[C@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)Cc3[nH][nH]c(=O)n3)c4ccc(cc4)F EX-A212
C[C@@]1(CSC(=N1)c2ccc(cc2O)O)C(=O)O EX-A214
CC1(COC1)COc2ccc3c(c2)ncn3c4ccc5cccc(c5n4)N6CCC(CC6)N EX-A215
Cc1cc(nc(n1)NS(=O)(=O)c2ccc(cc2)NC(=S)NC(=O)COc3ccc(cc3Cl)Br)C EX-A216
Cc1cccc(n1)c2c(nc([nH]2)C(C)(C)C)c3ccc4c(c3)OCO4 EX-A217
CCOC(=O)c1ccc(cc1)OCCC2CCN(CC2)c3ccc(nn3)C EX-A218
c1cc(ccc1c2[nH]c(c(n2)c3ccc(cc3)F)c4ccncc4)[N+](=O)[O-] EX-A219
COc1cc2c(cc1OC)ncnc2Nc3cccc(c3)Br.Cl EX-A220
CN(C)Cc1cccc(c1)N/C(=C\2/c3ccc(cc3NC2=O)C(=O)N)/c4ccccc4 EX-A221
CN(C)Cc1cccc(c1)N/C(=C\2/c3ccc(cc3NC2=O)C(=O)N(C)C)/c4ccccc4 EX-A222
c1ccc(cc1)Oc2cccc(c2)CNc3ccc(cc3)CCC(=O)O EX-A223
CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N EX-A224
c1cc(c(c(c1)Cl)C(=O)Nc2c[nH]nc2C(=O)NC3CCNCC3)Cl EX-A225
CC(C)n1cnc2c1nc(nc2NCCc3ccc(cc3)O)c4csc5c4cccc5 EX-A226
COc1cc2c(ccnc2cc1OC)Oc3ccc(c(c3)F)NC(=O)Nc4ccc(cc4F)F EX-A227
CC(=O)N1CCN(CC1)c2ccc(c(c2)OC)Nc3ncc(c(n3)Nc4cccc(c4)NC(=O)C=C)C(F)(F)F EX-A228
c1ccc(cc1)/C=C/Cn2cc(cn2)/C=C/C(=O)Nc3ccc(cc3N)F EX-A229
c1cc2c(cc1C#N)c(c([nH]2)O)c3ccc(cn3)CN4CCOCC4 EX-A230
COc1cc2c(cc1OC)CN(CC2)CCc3ccc(cc3)NC(=O)c4cc(c(cc4NC(=O)c5cc6ccccc6nc5)OC)OC EX-A231
CC1(CC2(CC(c3c2cc(cc3)O)(C)C)c4c1ccc(c4)O)C EX-A232
CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)c3cccc(c3)C(F)(F)F EX-A233
Cc1ccc(cc1OC)C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3c(nc4ccccc4n3)Nc5cc(cc(c5)OC)OC EX-A234
Cc1cc(n[nH]1)Nc2cc(nc(n2)/C=C/c3ccccc3)N4CCN(CC4)C EX-A235
c1ccc2c(c1)c3c(o2)c(ncn3)N4CCN(CC4)C(=S)NCc5ccc6c(c5)OCO6 EX-A236
c1cc(ccc1c2ccnc(n2)Nc3ccc(cc3)N4CCOCC4)NC(=O)[C@@H]5CCCN5 EX-A237
c1cc(cc(c1)O)CNC(=O)Nc2nc(cs2)c3ccncc3 EX-A238
CN1C/C=C/CCOc2cccc(c2)-c3ccnc(n3)Nc4cccc(c4)C1 EX-A239
c1cc2cc(c1)-c3ccnc(n3)Nc4ccc(c(c4)COC/C=C/COC2)OCCN5CCCC5 EX-A240
Cc1c(c(no1)c2ccccc2)c3ccc(cc3)S(=O)(=O)N EX-A241
c1cc(cc(c1)C(F)(F)F)CC(=O)Nc2cc(ccc2F)Oc3ccc4c(c3C#N)sc(n4)NC(=O)C5CC5 EX-A242
CCCNC[C@@]1([C@@H](O[C@H](C[C@@]1(C)OC)O[C@H]2[C@@H]([C@H]([C@](C[C@H](CN[C@@H]([C@H]([C@]([C@H](OC(=O)[C@@H]2C)CC)(C)O)O)C)C)(C)O)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)C)C)O EX-A243
CCCc1cc([nH]c(=O)c1CNC(=O)c2cc(cc3c2cnn3C(C)C)c4ccnc(c4)N5CCN(CC5)C)C EX-A244
Cc1cc(cc(c1Nc2ccnc(n2)Nc3ccc(cc3)C#N)C)/C=C/C#N EX-A245
c1cc2c(cc1Cl)c3c(o2)c(=O)[nH]c(n3)[C@@H]4CCCN4.Cl EX-A246
Cc1c(sc(n1)N(C)C(=O)Cc2ccc(cc2)c3ccccn3)S(=O)(=O)N EX-A247
CCc1cncnc1N2CCN(CC2)Cc3[nH]c4ccc(cc4n3)C(F)(F)F EX-A248
COc1cc2c(cc1C(=O)N)c(ccn2)Oc3ccc(c(c3)Cl)NC(=O)NC4CC4 EX-A249
CC(C)c1cc(c(cc1O)O)c2nnc(n2c3ccc4c(c3)ccn4C)O EX-A250
CN(C)CC(=O)Nc1ccc2c(c1)c3ccccc3c(=O)[nH]2.Cl EX-A251
CCCc1cc([nH]c(=O)c1CNC(=O)c2cc(cc3c2cnn3C(C)C)c4ccc(nc4)N5CCN(CC5)C(C)C)C EX-A252
c1ccc2c(c1)ccc3c2ccc(c3)c4cc(nn4c5ccc(cc5)NC(=O)CN)C(F)(F)F EX-A253
CC(c1ccc2c(c1)c(=O)oc3c2cc(c(c3)OCc4ccc(cc4)OC)OC)O EX-A254
COCCOc1ccc(cc1)Nc2ncc(c(n2)Nc3cccc(c3)NC(=O)C=C)F EX-A255
Cc1cccc(n1)c2c(nc([nH]2)C(C)(C)C)c3ccc4c(c3)nccn4 EX-A256
c1c(cncc1Br)C(=O)N2CCC(CC2)N3CCCC3 EX-A257
CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2c3ccccc3CC2C4Cc5ccccc5C4C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC EX-A258
c1ccc(cc1)c2cc3c(ccn4c3n[nH]c4=O)nc2c5ccc(cc5)C6(CCC6)N.Cl.Cl EX-A259
c1cc(ccc1c2ccnc(n2)Nc3ccc(cc3)N4CCOCC4)C(=O)NCC#N EX-A260
c1cc(ccc1N2CC(=NC2=O)N3CCOCC3)Cl EX-A261
c1cc(cc(c1)NC(=O)N2CCCC2)Nc3ncc(c(n3)NCCCNC(=O)c4cccs4)I EX-A262
c1cc(cc(c1)Cl)c2ccc(o2)C(=O)Nc3ccc(cc3)CN4CCOCC4 EX-A263
CC(C)(C)c1ccc(cc1)C(=O)NC(=S)Nc2ccc(cc2)N EX-A264
c1cc2c(cc1C(=O)N3CCCCC3)nccn2 EX-A265
COc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-] EX-A266
c1ccc2c(c1)c(c[nH]2)CCNc3ccc(cc3)Nc4ccncc4 EX-A267
c1cc(ccc1Nc2nc3c(c(n2)NC4CCCCC4)[nH]cn3)N5CCOCC5 EX-A268
c1ccc2cc(c(cc2c1)C(=O)N/N=C/c3ccc(c(c3)O)O)O.O EX-A269
c1c(cc(c2c1[nH]c(c2CCC(=O)O)C(=O)O)Cl)Cl EX-A270
Cc1ccc(cc1Nc2ccc\3c(c2)NC(=O)/C3=C\c4ccc[nH]4)NC(=O)Nc5cc(ccc5F)C(F)(F)F EX-A271
c1ccc2c(c1)C=Cc3ccccc3C2=C4CCN(CC4)CCCCc5[nH]nnn5 EX-A272
CCCC(=O)Nc1cccc(c1)NC(=O)c2ccccc2Br EX-A273
COc1ccc(cc1)C2(CCOCC2)CNC(=O)c3ccc(cc3)NC(=O)c4ccco4 EX-A274
c1ccc(c(c1)C(=O)OCCOCCO)Nc2cccc(c2)C(F)(F)F EX-A275
Cc1c(c(no1)c2ccccc2Cl)C(=O)N(C)c3ccc(cc3)Cl EX-A276
CC(C)CCNc1c(cccn1)C(=O)N2CCN(CC2)Cc3ccccc3 EX-A277
Cc1ccc(cc1OC)C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3c(nc4ccccc4n3)Nc5cc(cc(c5)OC)OC EX-A278
c1ccc(c(c1)N2CC=C(NC2=O)c3cccc(c3)[N+](=O)[O-])O EX-A279
c1ccc(cc1)C[C@@H](C(=O)Nc2ccc(cc2C(=O)O)I)NCc3ccccc3 EX-A280
Cn1c2ccccc2nc1SCC(=O)N3CCC[C@H]3C(=O)Nc4ccccc4c5ccccc5 EX-A281
C/C=C\1/[C@H]2C=C(C[C@@]1(c3c2[nH]c(=O)cc3)N)C EX-A282
c1ccc(cc1)CN2CCC(CC2)NC(=O)COc3ccc(cc3)C(=O)c4ccccc4 EX-A283
COCCOc1ccc2c(c1)ncn2c3ccc4cccc(c4n3)N5CCC(CC5)N EX-A284
c1cc(ccc1[C@H](CCO)NC(=O)C2(CCN(CC2)c3c4cc[nH]c4ncn3)N)Cl EX-A285
c1cc(c2c(c1)ncc(n2)c3cnn(c3)C4CCNCC4)c5cc(c(c(c5)F)CN6CCOCC6)F EX-A286
c1ccc(cc1)C(=O)COc2cccc3c2CCNC3=O EX-A287
Cc1nc2c(nc(nc2n1C(C)C)N3CCOCC3)c4cnc(nc4)N EX-A288
Cc1cc(ccn1)c2ccc(cc2)CC(=O)Nc3ccc(cc3)c4cccnc4 EX-A289
c1cc2cn(nc2c(c1)C(=O)N)c3ccc(cc3)[C@@H]4CCCNC4 EX-A290
Cn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4ccc(cc4Cl)Cl EX-A291
CC(C)(C)c1c(nc[nH]1)/C=c\2/c(=O)[nH]/c(=C\c3ccccc3)/c(=O)[nH]2 EX-A292
CN(C)c1ccc(cc1)c2cccc(c2)NC(=O)N(C)C EX-A293
CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)[N+](=O)[O-])C(=O)OC3CCCCC3 EX-A294
CCOc1ccccc1n2c(=O)c3ccccc3nc2C(C)N4CCN(CC4)C(=O)COc5ccc(cc5)Cl EX-A295
c1cnc(nc1)c2ccc(cc2)N3CCN(CC3)C(=O)CN4CC[C@H](C4)C(=O)Nc5ccc6c(c5)c(n[nH]6)c7ccncc7 EX-A296
COc1ccc(cn1)n2c(nnc2OC)N3CC(C3)Oc4ccc(cc4Cl)F EX-A297
c1c(ccc(c1)Cl)OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc3ccc(cc3)Cl EX-A298
CS(=O)(=O)c1ccc(cc1)NC(=O)c2cc(c(s2)Sc3c(cncc3Cl)Cl)C#N EX-A300
CNC(=O)c1c(cccc1F)Nc2c3cc[nH]c3nc(n2)Nc4cc5c(cc4OC)CCN5C(=O)CN(C)C EX-A301
Cc1ccc(cc1Nc2ccc3c(c2)c(=O)n(cn3)C)NC(=O)c4cccc(c4)C(C)(C)C#N EX-A302
Cc1c(sc(n1)NC(=O)NCCc2nnn(n2)CCF)c3ccc(c(c3)F)S(=O)(=O)C EX-A303
CN(C)C(=O)c1cc2cnc(nc2n1C3CCCC3)Nc4ccc(cn4)N5CCNCC5 EX-A304
c1cc2c(cc1Nc3nccc(n3)Nc4cc([nH]n4)C5CC5)[nH]cn2 EX-A305
C#Cc1cccc(c1)Nc2c3cc4c(cc3ncn2)OCCOCCOCCO4 EX-A306
Cc1c(n2cccnc2n1)c3csc(n3)Nc4c(cc(cc4Br)OC)Br EX-A307
c1ccc(cc1)c2cc([nH]c(=O)c2C#N)c3cc(ccc3O)Br EX-A308
COc1ccc(cc1NS(=O)(=O)c2cc(cc(c2O)Cl)Cl)c3ccccc3 EX-A309
c1ccc(cc1)CCNS(=O)(=O)c2ccc(cc2)N EX-A310
CS(=O)(=O)Nc1ccc(cc1)c2coc3cc(ccc3c2=O)OCc4cccc(c4)C(=O)O EX-A311
c1cc(cc(c1)C(=O)NCCO)c2cc(ncn2)Nc3ccc(cc3)OC(F)(F)F EX-A312
c1cc(ccc1c2[nH]c(c(n2)c3ccc(cc3)F)c4ccncc4)O EX-A313
Cn1cc(c2c1cccc2)c3ccnc(n3)Nc4cc(c(cc4OC)N(C)CCN(C)C)NC(=O)C=C EX-A314
CC(C)NCCCn1c2c(c(ncn2)N)nc1Sc3cc4c(cc3I)OCO4 EX-A315
CC(N([C@H]1C[C@H](C1)CCc2nc3c([nH]2)ccc(c3)C(C)(C)C)C[C@H]4O[C@H]([C@@H]([C@@H]4O)O)n5c6ncnc(c6nc5)N)C EX-A316
C/C=C/1\NC(=O)[C@@H]2NC(=O)C(NC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)/C=C/CCSSC2)[C@@H](C)C EX-A317
CC(C)OC(=O)/C=C\n1cnc(n1)c2cc(cc(c2)OC)C(F)(F)F EX-A318
Cc1nnc(s1)Sc2c3cc(c(cc3ncn2)OC)OC EX-A319
CCOC(=O)c1cnc2n1cc(cc2)c3cc(cnc3)NS(=O)(=O)c4ccccc4 EX-A320
CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)n3cc(c4c3ncnc4N)Br)O)O EX-A321
CCOC(=O)[C@H](Cc1ccc(cc1)c2cc(nc(n2)N)O[C@H](c3ccc(cc3n4ccc(n4)C)Cl)C(F)(F)F)N EX-A322
C[C@@H](C(=O)N[C@@H](c1ccccc1)C(=O)OC(C)(C)C)NC(=O)Cc2cc(cc(c2)F)F EX-A324
CC(C)(C)[Si](C)(C)O[C@@]12[C@@H](CC=CC1=O)[C@@H](c3c(c(no3)OCc4ccccc4)C2=O)N(C)C EX-A325
Cc1ccccc1n2c(nc3cccc(c3c2=O)C)Cn4cnc5c4ncnc5N EX-A326
c1ccc(cc1)Oc2ccc(cc2)CNC(=O)c3nc(no3)c4cc(c(c(c4)Br)O)Br EX-A327
COc1cc(ccc1Nc2ncc(c(n2)c3c[nH]c4c3cccc4)Cl)N5CCC(CC5)N EX-A328
Cc1cc(c2cc(cc(c2n1)F)F)NC(=O)Nc3ccc(cc3)N(C)C EX-A329
CC[C@@H](c1nc2cccc(c2c(=O)n1c3ccccc3)F)Nc4c5c([nH]cn5)ncn4 EX-A330
CC(C)(c1cccc(n1)n2c3c(cnc(n3)Nc4ccc(cc4)N5CCN(CC5)C)c(=O)n2CC=C)O EX-A331
Cc1ncc(s1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@]3(CO3)C EX-A332
Cc1cc([nH]c1/C=C\2/C(=CC(=N2)c3cc4ccccc4[nH]3)OC)C.CS(=O)(=O)O EX-A333
c1ccc2c(c1)c(nnc2Nc3ccc(cc3)Cl)Cc4ccncc4.Cl.Cl EX-A334
c1cc(ccc1c2cn3c4ccc(cc4sc3n2)OCCN5CCOCC5)N EX-A335
CCOc1cc(ccc1OC)[C@@H](CS(=O)(=O)C)N2C(=O)c3cccc(c3C2=O)NC(=O)C EX-A336
CNC(=O)c1ccccc1Sc2ccc3c(c2)[nH]nc3/C=C/c4ccccn4 EX-A337
CC(C)(C#N)c1ccc(cc1)N2c3c4cc(ccc4ncc3COC2=O)c5cc6ccccc6nc5 EX-A338
CN(C)c1ccccc1CN2CCCN(C2c3ccncc3)Cc4ccccc4N(C)C EX-A339
Cn1cc(c2c1ncnc2N)c3ccc4c(c3)CCN4C(=O)Cc5cccc(c5)C(F)(F)F EX-A340
CN1CCN(CC1)CC(=O)N(C)c2ccc(cc2)N/C(=C\3/c4ccc(cc4NC3=O)C(=O)OC)/c5ccccc5 EX-A341
Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(c(c2)O)C(=O)O EX-A342
Cc1cc(ccc1n2c(ccc2c3ccc(cc3)n4ccnc4)CCC(=O)O)C(=O)N EX-A343
Cc1ccc(cc1)c2c3c(ncnc3n(n2)C(C)(C)C)N EX-A344
CCOC(=O)[C@H](CCC(=O)N[C@@H](CSCc1ccccc1)C(=O)N[C@H](c2ccccc2)C(=O)OCC)N EX-A345
c1ccc2c(c1)nc(n2Cc3ccc(cc3)Cl)CN4CCCC4.Cl EX-A346
c1ccc2c(c1)/C(=C\3/c4ccccc4NC3=O)/C(=O)N2 EX-A347
c1ccc2c(c1)cccc2Oc3nc(c4c(n3)n(cn4)C5CCCCC5)Nc6ccc(cc6)N7CCOCC7 EX-A348
c1cc(cc(c1)F)c2ccc(cn2)C(=O)NC3CCN(CC3)CC(F)(F)F EX-A349
CC(C)(C)c1ccc(cc1)C(=O)NC(=S)Nc2ccc(cc2)NC(=O)CCCCN(C)C EX-A350
CCCCc1nc2cc(ccc2n1CCN(CC)CC)/C=C/C(=O)NO EX-A351
c1ccc2c(c1)/C(=C/CCN3CCN(CC3)CCO)/c4cc(ccc4S2)C(F)(F)F.Cl.Cl EX-A352
Cc1cc(ccc1c2ccc(cc2)S(=O)(=O)C)OCc3nnc(n3c4cccnc4)SC5CCCC5 EX-A353
CC(C)[C@H](CO)Nc1nc(c2c(n1)n(cn2)C(C)C)Nc3ccc(c(c3)Cl)C(=O)O EX-A354
c1ccc2c(c1)COC23CCN(CC3)CCCCc4cn(c5c4cccc5)c6ccc(cc6)F EX-A355
c1cc(cc(c1)NC(=O)Nc2cc(ccc2c3ccsc3)S(=O)(=O)NC4CC4)C(F)(F)F EX-A356
Cc1cc(nn1c2ccc3ccccc3c2)OCCN4CCOCC4.Cl EX-A357
CN(C)C(=N)c1ccc(cc1)C(=O)Nc2ccc(cc2C(=O)Nc3ccc(cn3)Cl)OC EX-A358
Cc1c(c2ccccc2[nH]1)CCNC(=O)c3cccs3 EX-A359
CCC(C(=O)N1c2ccccc2Sc3c1cccc3)Sc4nc5c6ccccc6[nH]c5nn4 EX-A360
CN1c2ccccc2/C(=C\3/c4ccccc4NC3=O)/C1=O EX-A361
CCCN1CCN(CC1)c2ccc(cc2)C(=O)NC3(CCCCC3)C(=O)NCC#N EX-A362
Cn1c(=O)c-2nc(nn(c2nc1=O)C)c3ccc(cc3)C(F)(F)F EX-A363
c1cc(ccc1CC(=O)NCCOCCOCCN)Nc2nc(nc(n2)NCC3CCCCC3)NCc4ccc(cc4)F EX-A364
CC(C)(C)[C@@H](C(=O)N[C@@H](Cc1ccccc1)[C@H](CNNC(=O)[C@H](C(C)(C)C)NC(=O)OC)O)NC(=O)OC EX-A365
c1ccc(cc1)C2=NOC(C2)CC(=O)O EX-A366
CCC(CC)n1c2c([nH]c1=O)ncc(n2)C#C EX-A367
c1ccc2c(c1)c(c3c(ccc(c3c2O)NCCNCCO)NCCNCCO)O EX-A368
c1cc(ccc1NC(=S)NNc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])F EX-A369
Cc1ccc(cc1Cl)NC(=S)NNc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] EX-A370
CN1CCCN(CC1)C(=O)c2cccc(c2)c3ccc(o3)/C=C/4\c5cc(ccc5NC4=O)Cl EX-A371
c1ccc(cc1)NCC(Cn2c3ccc(cc3c4c2ccc(c4)Br)Br)O EX-A372
COc1cccc(c1)NCC(Cn2c3ccc(cc3c4c2ccc(c4)Br)Br)F EX-A373
COc1cccc(c1)NC[C@H](Cn2c3ccc(cc3c4c2ccc(c4)Br)Br)O EX-A374
CC(C)n1cnc2c1nc(nc2c3cnc(nc3)N)N4CCOCC4 EX-A375
COc1cccc(c1)CNC(=O)Nc2nc(cs2)c3ccncc3 EX-A376
c1cc(sc1CSC(=N)N)CSC(=N)N.Cl.Cl EX-A377
Cn1c(=O)cc(n(c1=O)Cc2cc(ccc2C#N)F)N3CCC[C@H](C3)N.C(CC(=O)O)C(=O)O EX-A378
c1ccc(cc1)N(c2ccccc2Cl)c3ncc(cn3)C(=O)NCCCCCCC(=O)NO EX-A379
c1ccc(c(c1)c2ccc(cc2)c3csc4c3c(c(c(=O)[nH]4)C#N)O)O EX-A380
C/C(=C\C(=O)Nc1ccccc1C(=O)O)/c2ccc3ccccc3c2 EX-A381
CN1CCC(CC1)NC(=O)c2cc(c(cc2F)Nc3ncc4c(n3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC EX-A382
c1ccc(cc1)/C(=C\C(=O)O)/CCc2ccc(cc2)Cl EX-A383
Cn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4cn(c5c4cccc5)CCCSC(=N)N.CS(=O)(=O)O EX-A384
c1ccc(c(c1)c2nc(no2)c3cccc(c3)C(=O)O)F EX-A385
CC(C)(C)[C@@H](C(=O)N1CC(C[C@H]1C(=O)N(C(=O)[C@]2(C[C@H]2C=C)N)S(=O)(=O)C3CC3)Oc4c5cc(ccc5c(cn4)OC)Cl)NC(=O)OC(C)(C)C EX-A386
CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O EX-A387
Cc1cc(ccc1NS(=O)(=O)c2cc(ccc2Cl)Cl)[N+](=O)[O-] EX-A388
C[C@@H](C(=O)OC(C)C)NP(=O)(CC[C@@H]1[C@H]([C@@]([C@@H](O1)n2ccc(=O)[nH]c2=O)(C)F)O)Oc3ccccc3 EX-A389
Cc1c2cc(ccc2c(c(n1)C(=O)NCC(=O)O)O)Oc3ccccc3 EX-A390
CN1CCN(CC1)CCCOc2cc3c(cc2OC)c(c(cn3)C#N)Nc4cc(c(cc4Cl)Cl)OC EX-A391
Cc1cnc(nc1NCc2ccc(cc2)n3ccnn3)c4ccccc4C(C)C EX-A392
c1cc2c(cc1O)c3c(o2)C(=O)NCCC3 EX-A393
CN1CCC(CC1)COc2cnc(nc2)c3cccc(c3)Cn4c(=O)ccc(n4)c5cccc(c5)C#N EX-A394
CS(=O)(=O)n1cc2c(n1)CN(C2)[C@@H]3C[C@@H]([C@H](OC3)c4cc(ccc4F)F)N EX-A395
c1ccc(cc1)/C(=C(\c2ccccc2)/c3ccc(cc3)OCCO)/CCCl EX-A396
CCC(=O)N1CCN(CC1)c2ccc(cc2C(F)(F)F)n3c(=O)ccc4c3c5cc(ccc5nc4)c6cc7ccccc7nc6 EX-A397
CCCN[C@@H]1CCc2c(sc(n2)N)C1.Cl.Cl EX-A398
c1cc(cc(c1)Cl)OCC(/C=C/[C@H]2[C@@H](C[C@@H]([C@@H]2C/C=C\CCCC(=O)O)O)O)O EX-A399
c1cc2c(ccnc2cc1Cl)N3CCN(CC3)CCCN4CCN(CC4)c5ccnc6c5ccc(c6)Cl.OP(=O)(O)O EX-A400
Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl EX-A401
CS(=O)(=O)CCNCc1ccc(o1)c2ccc3c(c2)c(ncn3)Nc4ccc(c(c4)Cl)OCc5cccc(c5)F EX-A402
c1cc(c(cc1I)F)Nc2cnccc2C(=O)NC[C@@H](CO)O EX-A403
CC(C)(C#N)c1ccc(cc1)n2c3c4cc(ccc4ncc3n(c2=O)C)c5cc6ccccc6nc5 EX-A404
Cc1c(sc(n1)NC(=O)N2CCC[C@H]2C(=O)N)c3ccnc(c3)C(C)(C)C(F)(F)F EX-A405
CCc1cc2c(cc1N3CCC(CC3)N4CCOCC4)C(c5c(c6ccc(cc6[nH]5)C#N)C2=O)(C)C EX-A406
CCCc1ccc(cc1)Cc2cc(ccc2C)[C@]34[C@@H]([C@H]([C@@H]([C@](O3)(CO4)CO)O)O)O EX-A407
Cc1c2cnc(nc2n(c(=O)c1C(=O)C)C3CCCC3)Nc4ccc(cn4)N5CCNCC5 EX-A408
Cc1c(cccc1C(=O)Nc2ccc(nc2)N3C[C@H](O[C@H](C3)C)C)c4ccc(cc4)OC(F)(F)F EX-A409
CC(C)[C@@H](C(=O)N1CCC[C@H]1c2[nH]c(cn2)c3ccc(cc3)c4ccc(cc4)c5cnc([nH]5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC EX-A410
CC(C)[C@@H](C(=O)N1CC2(CC2)C[C@H]1c3[nH]c(cn3)c4ccc-5c(c4)C(c6c5ccc(c6)c7ccc8c(c7)[nH]c(n8)[C@@H]9[C@H]1CC[C@H](C1)N9C(=O)[C@H](C(C)C)NC(=O)OC)(F)F)NC(=O)OC EX-A411
CCS(=O)(=O)N1CC(C1)(CC#N)n2cc(cn2)c3c4cc[nH]c4ncn3 EX-A413
c1cc(ccc1Cc2ccc(cc2Cl)[C@H]3C(C([C@@H](C(O3)CO)O)O)O)O[C@@H]4CCOC4 EX-A414
CN1C2=NC=NC3C2C(=CN3[C@@H]4C[C@@H]([C@H]([C@H]4O)O)CO)C(=N1)N EX-A415
CN1CCN(CC1)c2ccc(c(c2)OC)Nc3ncc(c(n3)Oc4cccc(c4)NC(=O)C=C)Cl EX-A416
CN(C)[C@@H]1CCc2c(c3cc(ccc3[nH]2)NC(=O)c4ccc(cc4)F)C1.Cl EX-A417
CCO[C@H]1C(CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)c3ccc(c(c3)Cl)N EX-A418
CNC(=O)[C@@H](c1ccccc1)N2CCc3cc(c(cc3[C@H]2CCc4ccc(cc4)C(F)(F)F)OC)OC EX-A419
C[C@H]1[C@H](OC(=O)N1Cc2cc(ccc2c3cc(c(cc3OC)F)C(C)C)C(F)(F)F)c4cc(cc(c4)C(F)(F)F)C(F)(F)F EX-A420
Cc1ccc(cc1Cc2ccc(s2)c3ccc(cc3)F)[C@H]4C(C([C@@H](C(O4)CO)O)O)O EX-A421
COc1cc2c(cc1OCC3CCC(CC3)N)ncnc2Nc4ccc(cc4F)Br EX-A422
C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2.Cl.Cl EX-A423
c1cc(ccc1c2cnc3c(cnn3c2)c4ccncc4)OCCN5CCCCC5 EX-A424
c1cc(c2cccnc2c1)c3cnn4c3ncc(c4)c5ccc(cc5)N6CCNCC6 EX-A425
Cc1cc(c(cc1Br)NC(=O)Nc2cnc(cn2)C)OC[C@@H]3CNCCO3 EX-A426
CC(C)S(=O)(=O)c1ccccc1Nc2c(cnc(n2)Nc3ccc(cc3OC)N4CCC(CC4)N5CCN(CC5)C)Cl EX-A427
Cc1cc(no1)NC(=O)Nc2cc(c(cc2OC)OC)Cl EX-A428
Cc1cc([nH]c(=O)c1CNC(=O)c2cc(cc3c2cnn3C4CCCC4)c5ccc(cc5)CN6CCOCC6)C EX-A429
c1ccc(cc1)C(=O)N2CCC(CC2)CCCCNC(=O)/C=C/c3cccnc3 EX-A430
c1cc(cc(c1)n2c(=O)ccc3c2c4cc(ccc4nc3)c5ccc(nc5)N)C(F)(F)F EX-A431
CC(C)(C)c1cc(cc(c1OC)c2ccc3cc(ccc3c2)NS(=O)(=O)C)n4ccc(=O)[nH]c4=O EX-A432
CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4c2c(ccc4)O.Cl EX-A433
Cc1c(cccc1C(F)(F)F)Cn2c(nc3c2cc(cc3C(=O)O)N4CCOCC4)C EX-A434
c1ccc(cc1)c2c(n(cn2)Cc3ccc(cc3)Cl)c4c5ccc(cc5[nH]c4C(=O)O)Cl EX-A435
CN(C)CCCN(C)[C@@H]1CCN(C1)C(=O)c2c(c3ccc(cc3[nH]2)Cl)c4c(ncn4Cc5ccc(cc5)Cl)c6ccccc6 EX-A436
CN(C)CCCN(C)[C@@H]1CCN(C1)C(=O)c2c(c3ccc(cc3[nH]2)Cl)c4c(cnn4Cc5ccc(cc5)Cl)c6ccccc6 EX-A437
Cc1ccc(cc1NC(=O)CNc2ccc(c(c2)F)F)CN3CCNCC3.Cl.Cl.Cl EX-A438
Cc1cccc(n1)CC(=O)N2CCc3c2ccc(c3F)c4cn(c5c4c(ncn5)N)C EX-A439
Cn1c2cnc(nc2n(c1=O)C3CCCC3)Nc4ccc(cc4OC)OC5CCN(CC5)C EX-A440
CC(C)(C)c1cc(c(cc1NC(=O)c2c[nH]c3ccccc3c2=O)O)C(C)(C)C EX-A441
Cc1nnc(n1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](c4ccccc4)NC(=O)C5CCC(CC5)(F)F)C(C)C EX-A442
Cc1ccc(cc1C)N2C(=O)/C(=N\Nc3cccc(c3O)c4cccc(c4)C(=O)O)/C(=N2)C EX-A443
Cc1nc2ccc(cc2o1)NC(=O)Nc3ccnc4c3nccc4 EX-A444
COc1cc2c(cc1OC)ncnc2Nc3ccc(c(c3)Br)O EX-A445
CNC(=O)c1ccc(cc1F)c2cnc3ncc(n3n2)Cc4ccc5c(c4)cccn5 EX-A446
CC(=CC(=O)CCC(=O)N1CCN(CC1)Cc2cc3c(s2)c(nc(n3)c4cccc5c4cn[nH]5)N6CCOCC6)C EX-A447
CC(C)(CO)C(=O)Nc1ccc(cc1)NS(=O)(=O)c2cccc3c2cccc3N(C)C EX-A448
CCOC(=O)Nc1cc(nn2c1nnc2C)c3ccc(c(c3)NS(=O)(=O)C)C EB-A001