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Search Results | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF
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Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: DNC014577 DNC014577

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.46 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.46 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.46 Binding ≤ 10μM
TOP3-1-B DNA Topoisomerase III (cluster #1 Of 1), Bacterial Bacteria 420 0.50 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
TOP3_BACSU P96583 DNA Topoisomerase III, Bacsu 400 0.50 Binding ≤ 1μM
TOP3_BACSU P96583 DNA Topoisomerase III, Bacsu 400 0.50 Binding ≤ 10μM
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 1200 0.46 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 1200 0.46 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 1200 0.46 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.86 4.04 -9.12 3 5 0 78 243.266 2 ↓

Analogs

26908
26908

Draw Identity 99% 90% 80% 70%

Popular Name: 6-(indan-5-ylamino)-3-methyl-1H-pyrimidine-2,4-dione 6-(indan-5-ylamino)-3-methyl-1H-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 1340 0.43 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 1340 0.43 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 1340 0.43 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 1340 0.43 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 1340 0.43 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 1340 0.43 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.92 6.55 -9.41 2 5 0 67 257.293 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-ethyl-6-(indan-5-ylamino)-1H-pyrimidine-2,4-dione 3-ethyl-6-(indan-5-ylamino)-1H-p…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.46 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.46 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.46 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 310 0.46 Binding ≤ 1μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 310 0.46 Binding ≤ 1μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 310 0.46 Binding ≤ 1μM
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 310 0.46 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 310 0.46 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 310 0.46 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.30 7.54 -8.99 2 5 0 67 271.32 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-allyl-6-(indan-5-ylamino)-1H-pyrimidine-2,4-dione 3-allyl-6-(indan-5-ylamino)-1H-p…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 380 0.43 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 380 0.43 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 380 0.43 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 380 0.43 Binding ≤ 1μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 380 0.43 Binding ≤ 1μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 380 0.43 Binding ≤ 1μM
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 380 0.43 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 380 0.43 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 380 0.43 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.57 8.1 -9.24 2 5 0 67 283.331 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 6-(indan-5-ylamino)-3-propyl-1H-pyrimidine-2,4-dione 6-(indan-5-ylamino)-3-propyl-1H-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.43 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.43 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.43 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 310 0.43 Binding ≤ 1μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 310 0.43 Binding ≤ 1μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 310 0.43 Binding ≤ 1μM
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 310 0.43 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 310 0.43 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 310 0.43 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.80 8.3 -9.05 2 5 0 67 285.347 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-butyl-6-(indan-5-ylamino)-1H-pyrimidine-2,4-dione 3-butyl-6-(indan-5-ylamino)-1H-p…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 90 0.45 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 90 0.45 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 90 0.45 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 90 0.45 Binding ≤ 1μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 90 0.45 Binding ≤ 1μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 90 0.45 Binding ≤ 1μM
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 90 0.45 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 90 0.45 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 90 0.45 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.36 9.09 -9.02 2 5 0 67 299.374 5 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-hexyl-6-(indan-5-ylamino)-1H-pyrimidine-2,4-dione 3-hexyl-6-(indan-5-ylamino)-1H-p…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
RPC10-1-E DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 240 0.39 Binding ≤ 10μM
RPC4-1-E DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 240 0.39 Binding ≤ 10μM
RPC6-1-E DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic Eukaryotes 240 0.39 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 240 0.39 Binding ≤ 1μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 240 0.39 Binding ≤ 1μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 240 0.39 Binding ≤ 1μM
RPC6_HUMAN Q9H1D9 DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human 240 0.39 Binding ≤ 10μM
RPC4_HUMAN P05423 DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human 240 0.39 Binding ≤ 10μM
RPC10_HUMAN Q9Y2Y1 DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human 240 0.39 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.37 10.65 -8.9 2 5 0 67 327.428 7 ↓

Parameters Provided:

ring.id = 228349
filter.purchasability = annotated
page.format = targets
page.num = 1

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 228349 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

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