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ZINC Item

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65330700

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-acetylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-acetylphenyl)-1-thiazo…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.17	8.4	-16.31	1	6	0	75	380.473	4	↓ MOL2 SDF SMILES Flexibase

65330701

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-acetylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-acetylphenyl)-1-thiazo…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.17	8.41	-16.24	1	6	0	75	380.473	4	↓ MOL2 SDF SMILES Flexibase

65330702

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-1-thiazolo[5,4-b]pyridin-2-yl-N-[2-(trifluoromethyl)phenyl]piperidine-3-carboxamide (3R)-1-thiazolo[5,4-b]pyridin-2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.12	9.17	-11.87	1	5	0	58	406.433	4	↓ MOL2 SDF SMILES Flexibase

65330703

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-1-thiazolo[5,4-b]pyridin-2-yl-N-[2-(trifluoromethyl)phenyl]piperidine-3-carboxamide (3S)-1-thiazolo[5,4-b]pyridin-2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.12	9.19	-12	1	5	0	58	406.433	4	↓ MOL2 SDF SMILES Flexibase

65330704

Analogs

35505122
35505125

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-chloro-2-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-chloro-2-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	9.32	-12.52	1	5	0	58	386.908	3	↓ MOL2 SDF SMILES Flexibase

65330705

Analogs

35505122
35505125

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-chloro-2-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-chloro-2-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	9.31	-12.49	1	5	0	58	386.908	3	↓ MOL2 SDF SMILES Flexibase

65330706

Analogs

35505116
35505119

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(5-chloro-2-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(5-chloro-2-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	9.34	-13.67	1	5	0	58	386.908	3	↓ MOL2 SDF SMILES Flexibase

65330707

Analogs

35505116
35505119

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(5-chloro-2-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(5-chloro-2-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	9.32	-13.59	1	5	0	58	386.908	3	↓ MOL2 SDF SMILES Flexibase

65330710

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(2,6-dimethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(2,6-dimethylphenyl)-1-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.14	9.44	-12.62	1	5	0	58	366.49	3	↓ MOL2 SDF SMILES Flexibase

65330711

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(2,6-dimethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(2,6-dimethylphenyl)-1-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.14	9.76	-13.07	1	5	0	58	366.49	3	↓ MOL2 SDF SMILES Flexibase

65330712

Analogs

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Popular Name: ethyl ethyl

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.80	9.48	-19.02	1	7	0	84	410.499	6	↓ MOL2 SDF SMILES Flexibase

65330713

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.80	9.5	-19.36	1	7	0	84	410.499	6	↓ MOL2 SDF SMILES Flexibase

65330714

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-ethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-ethylphenyl)-1-thiazol…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.19	9.35	-12.67	1	5	0	58	366.49	4	↓ MOL2 SDF SMILES Flexibase

65330715

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-ethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-ethylphenyl)-1-thiazol…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.19	9.35	-12.78	1	5	0	58	366.49	4	↓ MOL2 SDF SMILES Flexibase

65330718

Analogs

35505200
35505203
35505224
35505227

Draw Identity 99% 90% 80% 70%

Popular Name: methyl methyl

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.58	8.9	-13.85	1	7	0	84	396.472	5	↓ MOL2 SDF SMILES Flexibase

65330719

Analogs

35505200
35505203
35505224
35505227

Draw Identity 99% 90% 80% 70%

Popular Name: methyl methyl

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.58	8.9	-13.37	1	7	0	84	396.472	5	↓ MOL2 SDF SMILES Flexibase

65330720

Analogs

35505161
35505164

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(o-tolyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(o-tolyl)-1-thiazolo[5,4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.67	8.8	-12.78	1	5	0	58	352.463	3	↓ MOL2 SDF SMILES Flexibase

65330721

Analogs

35505161
35505164

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(o-tolyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(o-tolyl)-1-thiazolo[5,4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.67	8.8	-12.76	1	5	0	58	352.463	3	↓ MOL2 SDF SMILES Flexibase

65330722

Analogs

35505111
35505114
35505116
35505119
35505122

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3-chloro-4-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3-chloro-4-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	9.01	-12.2	1	5	0	58	386.908	3	↓ MOL2 SDF SMILES Flexibase

65330723

Analogs

35505111
35505114
35505116
35505119
35505122

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3-chloro-4-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3-chloro-4-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	9.02	-12.16	1	5	0	58	386.908	3	↓ MOL2 SDF SMILES Flexibase

65330724

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.82	9.49	-15.57	1	7	0	84	410.499	6	↓ MOL2 SDF SMILES Flexibase

65330725

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.82	9.5	-15.65	1	7	0	84	410.499	6	↓ MOL2 SDF SMILES Flexibase

65330726

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3,4-dimethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3,4-dimethylphenyl)-1-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.10	9.14	-12.92	1	5	0	58	366.49	3	↓ MOL2 SDF SMILES Flexibase

65330727

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3,4-dimethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3,4-dimethylphenyl)-1-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.10	9.14	-13.04	1	5	0	58	366.49	3	↓ MOL2 SDF SMILES Flexibase

65330728

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3,5-dimethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3,5-dimethylphenyl)-1-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.10	9.25	-12.94	1	5	0	58	366.49	3	↓ MOL2 SDF SMILES Flexibase

65330729

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3,5-dimethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3,5-dimethylphenyl)-1-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.10	9.25	-13.05	1	5	0	58	366.49	3	↓ MOL2 SDF SMILES Flexibase

65330730

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3-acetylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3-acetylphenyl)-1-thiazo…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.15	8.4	-20.55	1	6	0	75	380.473	4	↓ MOL2 SDF SMILES Flexibase

65330731

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3-acetylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3-acetylphenyl)-1-thiazo…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.15	8.4	-21	1	6	0	75	380.473	4	↓ MOL2 SDF SMILES Flexibase

65330732

Analogs

35505106
35505108
35505218
35505221

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-bromo-3-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-bromo-3-methyl-phenyl)…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.46	9.1	-12.73	1	5	0	58	431.359	3	↓ MOL2 SDF SMILES Flexibase

65330733

Analogs

35505106
35505108
35505218
35505221

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-bromo-3-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-bromo-3-methyl-phenyl)…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.46	9.1	-12.84	1	5	0	58	431.359	3	↓ MOL2 SDF SMILES Flexibase

65330734

Analogs

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Popular Name: (3R)-N-(2-ethyl-6-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(2-ethyl-6-methyl-phenyl)…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.60	10.41	-12.78	1	5	0	58	380.517	4	↓ MOL2 SDF SMILES Flexibase

65330735

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(2-ethyl-6-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(2-ethyl-6-methyl-phenyl)…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.60	10.41	-12.73	1	5	0	58	380.517	4	↓ MOL2 SDF SMILES Flexibase

65330736

Analogs

35505145
35505148

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-isopropylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-isopropylphenyl)-1-thi…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.79	9.83	-12.55	1	5	0	58	380.517	4	↓ MOL2 SDF SMILES Flexibase

65330737

Analogs

35505161
35505164
35505218
35505221

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-isopropylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-isopropylphenyl)-1-thi…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.79	9.83	-12.64	1	5	0	58	380.517	4	↓ MOL2 SDF SMILES Flexibase

65330738

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3-ethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3-ethylphenyl)-1-thiazol…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.17	9.35	-12.57	1	5	0	58	366.49	4	↓ MOL2 SDF SMILES Flexibase

65330739

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3-ethylphenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3-ethylphenyl)-1-thiazol…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.17	9.35	-12.65	1	5	0	58	366.49	4	↓ MOL2 SDF SMILES Flexibase

65330740

Analogs

35505151
35505154
35505156
35505159
35505190

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3-fluoro-4-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3-fluoro-4-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.81	8.62	-12.64	1	5	0	58	370.453	3	↓ MOL2 SDF SMILES Flexibase

65330741

Analogs

35505151
35505154
35505156
35505159
35505190

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3-fluoro-4-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3-fluoro-4-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.81	8.62	-12.65	1	5	0	58	370.453	3	↓ MOL2 SDF SMILES Flexibase

65330744

Analogs

35505134
35505136
35505151
35505154
35505156

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-fluoro-2-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-fluoro-2-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.81	8.88	-13.03	1	5	0	58	370.453	3	↓ MOL2 SDF SMILES Flexibase

65330745

Analogs

35505134
35505136
35505151
35505154
35505156

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-fluoro-2-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-fluoro-2-methyl-phenyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.81	8.87	-13.02	1	5	0	58	370.453	3	↓ MOL2 SDF SMILES Flexibase

65330746

Analogs

35505127
35505131
35505139
35505142
35505172

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(2-methoxy-5-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(2-methoxy-5-methyl-pheny…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.71	8.01	-12.93	1	6	0	67	382.489	4	↓ MOL2 SDF SMILES Flexibase

65330747

Analogs

35505127
35505131
35505139
35505142
35505172

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(2-methoxy-5-methyl-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(2-methoxy-5-methyl-pheny…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.71	8.01	-12.81	1	6	0	67	382.489	4	↓ MOL2 SDF SMILES Flexibase

65330748

Analogs

35505127
35505131
35505194
35505197

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(3-chloro-4-methoxy-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(3-chloro-4-methoxy-pheny…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.94	7.76	-13.82	1	6	0	67	402.907	4	↓ MOL2 SDF SMILES Flexibase

65330749

Analogs

35505127
35505131
35505194
35505197

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(3-chloro-4-methoxy-phenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(3-chloro-4-methoxy-pheny…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.94	7.76	-13.79	1	6	0	67	402.907	4	↓ MOL2 SDF SMILES Flexibase

65330750

Analogs

35505106
35505108
35505111
35505114
35505122

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(4-acetamidophenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(4-acetamidophenyl)-1-thi…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.49	6.83	-20.69	2	7	0	87	395.488	4	↓ MOL2 SDF SMILES Flexibase

65330751

Analogs

35505106
35505108
35505111
35505114
35505116

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(4-acetamidophenyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(4-acetamidophenyl)-1-thi…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.49	6.82	-20.94	2	7	0	87	395.488	4	↓ MOL2 SDF SMILES Flexibase

65330752

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-[4-(diethylamino)-2-methyl-phenyl]-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-[4-(diethylamino)-2-methy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.50	11.18	-84.3	2	6	0	63	424.594	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.50	11.1	-13.21	1	6	0	61	423.586	6	↓ MOL2 SDF SMILES Flexibase

65330753

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-[4-(diethylamino)-2-methyl-phenyl]-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-[4-(diethylamino)-2-methy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.50	11.17	-84.57	2	6	0	63	424.594	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.50	11.11	-13.16	1	6	0	61	423.586	6	↓ MOL2 SDF SMILES Flexibase

65330754

Analogs

35505106
35505108
35505111
35505114
35505116

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-N-(p-tolyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3R)-N-(p-tolyl)-1-thiazolo[5,4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.72	8.58	-12.83	1	5	0	58	352.463	3	↓ MOL2 SDF SMILES Flexibase

65330755

Analogs

35505106
35505108
35505111
35505114
35505116

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-N-(p-tolyl)-1-thiazolo[5,4-b]pyridin-2-yl-piperidine-3-carboxamide (3S)-N-(p-tolyl)-1-thiazolo[5,4-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.72	8.59	-12.98	1	5	0	58	352.463	3	↓ MOL2 SDF SMILES Flexibase

Parameters Provided:

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Structural Results Found: (before additional filtering)

SQL Query Was

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