UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: 8-benzyl-2,8-diazaspiro[4.5]decane 8-benzyl-2,8-diazaspiro[4.5]decane

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.13 7.85 -99.55 3 2 2 21 232.371 2 ↓

Analogs

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Popular Name: 3-cyclopropyl-3,8-diazaspiro[4.5]decane 3-cyclopropyl-3,8-diazaspiro[4.5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.75 5.71 -90.84 3 2 2 21 182.311 1 ↓

Analogs

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Popular Name: 3-isopropyl-3,8-diazaspiro[4.5]decane 3-isopropyl-3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.05 5.52 -89 3 2 2 21 184.327 1 ↓
Hi High (pH 8-9.5) 1.05 3.07 -38.66 2 2 1 20 183.319 1 ↓

Analogs

39320992
39320992
39320994
39320994

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Popular Name: 8-methyl-2,8-diazaspiro[4.5]decane 8-methyl-2,8-diazaspiro[4.5]decane

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.73 4.29 -91.65 3 2 2 21 156.273 0 ↓
Hi High (pH 8-9.5) 0.73 1.9 -37.99 2 2 1 20 155.265 0 ↓

Analogs

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Popular Name: 5-methyl-2-(8-methyl-3,8-diazaspiro[4.5]decan-3-yl)pyrimidin-4-amine 5-methyl-2-(8-methyl-3,8-diazasp…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.64 8.58 -76.89 4 5 2 61 263.389 1 ↓
Mid Mid (pH 6-8) 1.64 8.15 -42.68 3 5 1 59 262.381 1 ↓

Analogs

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Popular Name: (2-methyl-2,8-diazaspiro[4.5]decan-8-yl)-(2-propylpyrazol-3-yl)methanone (2-methyl-2,8-diazaspiro[4.5]dec…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.58 7.57 -44.95 1 5 1 43 291.419 3 ↓

Analogs

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Popular Name: [5-(diethylaminomethyl)-2-methyl-3-furyl]-(8-methyl-3,8-diazaspiro[4.5]decan-3-yl)methanone [5-(diethylaminomethyl)-2-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.50 10.62 -86.95 2 5 2 42 349.519 5 ↓

Analogs

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Popular Name: 4-[5-fluoro-2-(8-methyl-2,8-diazaspiro[4.5]decan-2-yl)pyrimidin-4-yl]morpholine 4-[5-fluoro-2-(8-methyl-2,8-diaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.99 9.64 -41.76 1 6 1 46 336.435 2 ↓

Analogs

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Popular Name: 2-(3-methyl-3,8-diazaspiro[4.5]decane-8-carbonyl)benzonitrile 2-(3-methyl-3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.25 8.46 -53.63 1 4 1 49 284.383 1 ↓

Analogs

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Popular Name: 1-(3-methyl-3,8-diazaspiro[4.5]decan-8-yl)-3-piperazin-1-yl-propan-1-one 1-(3-methyl-3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.10 4.75 -89.48 3 5 2 45 296.459 3 ↓
Hi High (pH 8-9.5) -0.10 3.4 -44.37 2 5 1 40 295.451 3 ↓

Analogs

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Popular Name: 1-[4-[2-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)-2-oxo-ethoxy]phenyl]propan-1-one 1-[4-[2-(2-methyl-2,8-diazaspiro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.38 10.45 -51.44 1 5 1 51 345.463 5 ↓

Analogs

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Popular Name: 3-(1,2-dimethylimidazol-4-yl)sulfonyl-8-methyl-3,8-diazaspiro[4.5]decane 3-(1,2-dimethylimidazol-4-yl)sul…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.32 5.07 -45.42 1 6 1 60 313.447 2 ↓

Analogs

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Popular Name: 2-[3-(3-methyl-3,8-diazaspiro[4.5]decan-8-yl)-3-oxo-propyl]isoindolin-1-one 2-[3-(3-methyl-3,8-diazaspiro[4.…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.22 9.38 -51.39 1 5 1 45 342.463 3 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.83 5.32 -43.1 1 4 1 34 213.301 1 ↓

Analogs

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Popular Name: 2-methyl-8-(p-tolylsulfonyl)-2,8-diazaspiro[4.5]decane 2-methyl-8-(p-tolylsulfonyl)-2,8…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.34 6.91 -45.31 1 4 1 42 309.455 2 ↓

Analogs

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Popular Name: (2-hydroxy-5-methoxy-phenyl)-(8-methyl-2,8-diazaspiro[4.5]decan-2-yl)methanone (2-hydroxy-5-methoxy-phenyl)-(8-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.06 5.84 -46.42 2 5 1 54 305.398 2 ↓
Hi High (pH 8-9.5) 2.06 6.79 -81.16 1 5 0 57 304.39 2 ↓

Analogs

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Popular Name: (8-methyl-2,8-diazaspiro[4.5]decan-2-yl)-[(5R,7S)-3-(1,2,4-triazol-1-yl)-1-adamantyl]methanone (8-methyl-2,8-diazaspiro[4.5]dec…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.89 11.9 -51.3 1 6 1 55 384.548 2 ↓

Analogs

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Popular Name: N-(2,6-dichloro-4-pyridyl)-8-methyl-2,8-diazaspiro[4.5]decane-2-carboxamide N-(2,6-dichloro-4-pyridyl)-8-met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.08 7.12 -44.5 2 5 1 50 344.266 1 ↓

Analogs

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Popular Name: 1-(3-methyl-3,8-diazaspiro[4.5]decan-8-yl)-3-phenoxy-propan-1-one 1-(3-methyl-3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.25 8.86 -44.39 1 4 1 34 303.426 4 ↓

Analogs

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Popular Name: 2-(3-methyl-3,8-diazaspiro[4.5]decan-8-yl)propane-1,3-diol 2-(3-methyl-3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.30 2.8 -86.57 4 4 2 49 230.352 3 ↓
Hi High (pH 8-9.5) -0.30 0.18 -33.14 3 4 1 48 229.344 3 ↓
Hi High (pH 8-9.5) -0.30 0.54 -37.18 3 4 1 48 229.344 3 ↓

Analogs

44526182
44526182

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Popular Name: 3-methyl-8-(1-piperidylsulfonyl)-3,8-diazaspiro[4.5]decane 3-methyl-8-(1-piperidylsulfonyl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.26 5.26 -45.8 1 5 1 45 302.464 2 ↓

Analogs

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Popular Name: 1-(4-fluorophenyl)-4-(8-methyl-2,8-diazaspiro[4.5]decan-2-yl)butane-1,4-dione 1-(4-fluorophenyl)-4-(8-methyl-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.15 10.02 -44.53 1 4 1 42 333.427 4 ↓

Analogs

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Popular Name: 3-(4-acetyl-3,5-dimethyl-pyrazol-1-yl)-1-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)propan-1-one 3-(4-acetyl-3,5-dimethyl-pyrazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.91 8.82 -50.89 1 6 1 60 347.483 4 ↓

Analogs

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Popular Name: 2-(3,4-dimethoxyphenyl)sulfonyl-8-methyl-2,8-diazaspiro[4.5]decane 2-(3,4-dimethoxyphenyl)sulfonyl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 5.37 -48.27 1 6 1 60 355.48 4 ↓

Analogs

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Popular Name: [2-hydroxy-5-(tetrazol-1-yl)phenyl]-(3-methyl-3,8-diazaspiro[4.5]decan-8-yl)methanone [2-hydroxy-5-(tetrazol-1-yl)phen…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.87 5.8 -52.53 2 8 1 89 343.411 2 ↓
Hi High (pH 8-9.5) 0.87 6.61 -70.32 1 8 0 91 342.403 2 ↓

Analogs

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Popular Name: 4-amino-2-(3-methyl-3,8-diazaspiro[4.5]decan-8-yl)pyrimidine-5-carbonitrile 4-amino-2-(3-methyl-3,8-diazaspi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.95 8.04 -43 3 6 1 83 273.364 1 ↓

Analogs

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Popular Name: 7,16-bis{4-nitrobenzyl}-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 7,16-bis{4-nitrobenzyl}-1,4,10,1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.46 7.25 -51.39 1 6 1 64 355.462 1 ↓

Analogs

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Popular Name: 2-ethyl-2-hydroxy-1-(8-methyl-3,8-diazaspiro[4.5]decan-3-yl)butan-1-one 2-ethyl-2-hydroxy-1-(8-methyl-3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.48 5.26 -42.78 2 4 1 45 269.409 3 ↓

Analogs

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Popular Name: isopropyl 2-({2-nitrobenzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate isopropyl 2-({2-nitrobenzoyl}ami…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.93 5.33 -47.55 1 6 1 60 355.48 4 ↓

Analogs

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Popular Name: ethyl 2-({3-nitrobenzoyl}amino)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ethyl 2-({3-nitrobenzoyl}amino)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 8.86 -51.83 2 6 1 63 360.478 5 ↓

Analogs

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Popular Name: 2-(1-azocanyl)-N'-(3-bromo-4-hydroxy-5-methoxybenzylidene)acetohydrazide 2-(1-azocanyl)-N'-(3-bromo-4-hyd…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.75 7.89 -45.16 1 5 1 41 303.43 2 ↓
Lo Low (pH 4.5-6) 0.75 8.22 -90.05 2 5 2 42 304.438 2 ↓

Analogs

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Popular Name: 2-(3-phenyl-2-propenylidene)hydrazinecarboximidamide 2-(3-phenyl-2-propenylidene)hydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.92 8.67 -51.82 1 6 1 55 348.858 1 ↓

Analogs

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Popular Name: 3,8-diazaspiro[4.5]decan-3-ylmethylBLAHone 3,8-diazaspiro[4.5]decan-3-ylmet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.26 7.3 -49.08 2 4 1 42 338.475 2 ↓
Lo Low (pH 4.5-6) 2.26 9.8 -111.97 3 4 2 43 339.483 2 ↓

Analogs

44513082
44513082

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Popular Name: (3-methyl-3,8-diazaspiro[4.5]decan-8-yl)-(1H-pyrrol-2-yl)methanone (3-methyl-3,8-diazaspiro[4.5]dec…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.17 6.52 -49.08 2 4 1 41 248.35 1 ↓

Analogs

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Popular Name: 3-(2,6-dichlorophenyl)sulfonyl-3,8-diazaspiro[4.5]decane 3-(2,6-dichlorophenyl)sulfonyl-3…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.55 5.2 -50.11 2 4 1 54 350.291 2 ↓

Analogs

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Popular Name: N-(m-tolylmethyl)-3,8-diazaspiro[4.5]decane-3-carboxamide N-(m-tolylmethyl)-3,8-diazaspiro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.41 6.51 -45.98 3 4 1 49 288.415 2 ↓

Analogs

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Popular Name: 6-methyl-4-(8-methyl-3,8-diazaspiro[4.5]decane-3-carbonyl)-1H-pyridin-2-one 6-methyl-4-(8-methyl-3,8-diazasp…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.36 5.92 -51.08 2 5 1 58 290.387 1 ↓

Analogs

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Popular Name: 2-chloro-3-(3,8-diazaspiro[4.5]decan-3-ylmethyl)-9-methyl-pyrido[1,2-a]pyrimidin-4-one 2-chloro-3-(3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.02 8.85 -89 3 5 2 55 348.878 2 ↓
Mid Mid (pH 6-8) 2.02 6.36 -47.31 2 5 1 54 347.87 2 ↓

Analogs

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Popular Name: 5-methyl-4-[2-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)-2-oxo-ethyl]-1,2-dihydropyrazol-3-one 5-methyl-4-[2-(2-methyl-2,8-diaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.54 1.71 -50.77 3 6 1 74 293.391 2 ↓

Analogs

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Popular Name: N-(o-tolyl)-3,8-diazaspiro[4.5]decane-3-carboxamide N-(o-tolyl)-3,8-diazaspiro[4.5]d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.13 6.62 -47.26 3 4 1 49 274.388 1 ↓

Analogs

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Popular Name: 3-[[1-(3-pyridyl)pyrrol-2-yl]methyl]-3,8-diazaspiro[4.5]decane 3-[[1-(3-pyridyl)pyrrol-2-yl]met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.42 8.88 -93.64 3 4 2 39 298.434 3 ↓
Hi High (pH 8-9.5) 1.42 6.38 -42.71 2 4 1 38 297.426 3 ↓

Analogs

44512284
44512284
44516102
44516102
44517645
44517645

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Popular Name: 3-(3-methylsulfanylpropyl)-3,8-diazaspiro[4.5]decane 3-(3-methylsulfanylpropyl)-3,8-d…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.18 7 -95.41 3 2 2 21 230.421 4 ↓
Hi High (pH 8-9.5) 1.18 4.48 -40.15 2 2 1 20 229.413 4 ↓

Analogs

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Popular Name: 2-(3,8-diazaspiro[4.5]decan-3-yl)-5-fluoro-N-methyl-pyrimidin-4-amine 2-(3,8-diazaspiro[4.5]decan-3-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.30 6.4 -47.44 3 5 1 58 266.344 2 ↓
Mid Mid (pH 6-8) 1.30 6.84 -83.14 4 5 2 59 267.352 2 ↓

Analogs

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Popular Name: 5-(hydroxymethyl)-2-methyl-4-[(8-methyl-3,8-diazaspiro[4.5]decan-3-yl)methyl]pyridin-3-ol 5-(hydroxymethyl)-2-methyl-4-[(8…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.55 4 -105.58 4 5 2 62 307.438 3 ↓
Mid Mid (pH 6-8) 0.55 1.43 -42.18 3 5 1 61 306.43 3 ↓
Mid Mid (pH 6-8) 0.55 2.44 -51.36 3 5 1 65 306.43 3 ↓

Analogs

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Popular Name: 3-(2-methoxy-5-methyl-phenyl)sulfonyl-3,8-diazaspiro[4.5]decane 3-(2-methoxy-5-methyl-phenyl)sul…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.72 4.42 -50.91 2 5 1 63 325.454 3 ↓

Analogs

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Popular Name: 2-(3,8-diazaspiro[4.5]decan-3-ylmethyl)-5-methyl-phenol 2-(3,8-diazaspiro[4.5]decan-3-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.15 5.87 -98.46 4 3 2 41 262.397 2 ↓

Analogs

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Popular Name: (3S)-3-(3,8-diazaspiro[4.5]decan-3-ylmethyl)-3-hydroxy-1-phenethyl-piperidin-2-one (3S)-3-(3,8-diazaspiro[4.5]decan…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.37 7.88 -101.99 4 5 2 62 373.541 5 ↓
Hi High (pH 8-9.5) 1.37 7.11 -42.72 3 5 1 60 372.533 5 ↓

Analogs

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Popular Name: (3R)-3-(3,8-diazaspiro[4.5]decan-3-ylmethyl)-3-hydroxy-1-phenethyl-piperidin-2-one (3R)-3-(3,8-diazaspiro[4.5]decan…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.37 8.25 -101.1 4 5 2 62 373.541 5 ↓
Hi High (pH 8-9.5) 1.37 6.06 -48.24 3 5 1 60 372.533 5 ↓

Analogs

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Popular Name: ethyl ethyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.70 4 -42.37 3 7 1 83 323.417 5 ↓
Mid Mid (pH 6-8) 0.70 6.53 -105.72 4 7 2 84 324.425 5 ↓

Analogs

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Popular Name: 3-[[5-(1H-pyrazol-5-yl)-2-furyl]methyl]-3,8-diazaspiro[4.5]decane 3-[[5-(1H-pyrazol-5-yl)-2-furyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.22 6.33 -103.5 4 5 2 63 288.395 3 ↓

Parameters Provided:

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Structural Results Found: (before additional filtering)

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