UCSF

ZINC00620751

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.06 6.61 -21.14 2 7 0 98 311.297 3

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
TRPM8-1-E Transient Receptor Potential Cation Channel Subfamily M Member 8 (cluster #1 Of 1), Eukaryotic Eukaryotes 60 0.44 Binding ≤ 10μM
TRPM8-1-E Transient Receptor Potential Cation Channel Subfamily M Member 8 (cluster #1 Of 1), Eukaryotic Eukaryotes 190 0.41 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
TRPM8_HUMAN Q7Z2W7 Transient Receptor Potential Cation Channel Subfamily M Member 8, Human 60 0.44 Binding ≤ 1μM
TRPM8_HUMAN Q7Z2W7 Transient Receptor Potential Cation Channel Subfamily M Member 8, Human 60 0.44 Binding ≤ 10μM
TRPM8_RAT Q8R455 Transient Receptor Potential Cation Channel Subfamily M Member 8, Rat 190 0.41 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
TRP channels

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.