UCSF

ZINC03956919

Substance Information

In ZINC since Heavy atoms Benign functionality
October 25th, 2005 25 Yes

CAS Numbers: 41859-67-0 , 63927-29-7 , [41859-67-0]

Other Names:

fibrate

2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid

2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid

2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid; BF-759; BM 15075; BM-15.075; BRN 4267656; Bezafibrat; Bezafibrate; Bezafibrate [USAN:BAN:INN:JAN]; Bezafibrato [INN-Spanish]; Bezafibrato [Spanish]; Bezafibratum [INN-Latin]; Bezalip; C19H2

2-[4-(2-[4-Chlorobenzamido]ethyl)- phenoxy]-2-methylpropanoic acid

2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid

2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]isobutyric Acid

2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid

41859-67-0

41859-67-0; Bezafibrate (JP16/USAN/INN); Bezatol SR (TN); D01366

41859-67-0; Bezafibrate; Prestwick_724

a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid

AB00052265

AB1004588

AC-6817

AC1L20XS

AC1Q5E4V

AKOS005107743

Azufibrat

Azupharma Brand of Bezafibrate

B3346

B7273_SIGMA

Bayer Brand of Bezafibrate

Befibrat

Befizal

Befizal; Bezalip

Berlin Chemie Brand of Bezafibrate

Berlin-Chemie Brand of Bezafibrate

Betapharm Brand of Bezafibrate

Beza Lande

Beza Puren

Beza-Lande

Beza-Puren

Bezabeta

Bezacur

Bezafibrat

Bezafibrat PB

Bezafibrat;Bezafibrato [inn-spanish];Bezafibratum [inn-latin]

Bezafibrate (BAN

Bezafibrate (JP15/USAN/INN)

Bezafibrate Azupharma Brand

Bezafibrate Bayer Brand

Bezafibrate Berlin-Chemie Brand

Bezafibrate Betapharm Brand

Bezafibrate Cryopharma Brand

Bezafibrate Elfar Brand

Bezafibrate Hennig Brand

Bezafibrate Hexal Brand

Bezafibrate Isis Brand

Bezafibrate Lakeside Brand

Bezafibrate Merckle Brand

Bezafibrate Roche Brand

Bezafibrate Synthelabo Brand

Bezafibrate TAD Brand

Bezafibrate Teva Brand

Bezafibrate [USAN:BAN:INN:JAN]

bezafibrate; bezafibrato; bezafibratum

Bezafibrato

Bezafibrato [inn-spanish]

Bezafibrato [Spanish]

Bezafibratum

Bezafibratum [inn-latin]

Bezafisal

BezaLande

Bezalip

Bezalip retard

Bezalip SR

Bezamerck

BezaPuren

Bezatol

Bezatol SR

Bezatol SR (TN)

BF-759

Bio2_000034

Bio2_000514

BM 15.075

BM 15075

BM-15.075

BM-15075

BM15.075

Boehringer Mannheim Brand of Bezafibrate

BPBio1_000589

BRD-K46018455-001-06-0

BRN 4267656

BSPBio_000535

BSPBio_001314

BSPBio_003119

C19H20ClNO4

CAS-41859-67-0

CCRIS 9085

Cedur

CHEBI:47611; CHEBI:31284

CHEBI:47612

CHEMBL264374

CID39042

Cryopharma Brand of Bezafibrate

D001629

D01366

DAP001182

DB01393

DB08380

Difaterol

DivK1c_000092

durabezur

EINECS 255-567-9

Elfar Brand of Bezafibrate

Eulitop

Hennig Brand of Bezafibrate

Hexal Brand of Bezafibrate

HMS1361B16

HMS1569K17

HMS1791B16

HMS1921H16

HMS1989B16

HMS2089F04

HMS2092B12

HMS500E14

I06-1311

IDI1_000092

IDI1_033784

INN

INN)

Isis Brand of Bezafibrate

JAN

KBio1_000092

KBio2_000034

KBio2_001923

KBio2_002602

KBio2_004491

KBio2_005170

KBio2_007059

KBio3_000067

KBio3_000068

KBio3_002619

KBioGR_000034

KBioGR_000669

KBioSS_000034

KBioSS_001923

Lakeside Brand of Bezafibrate

Lipox

LO 44

LS-124535

Merckle Brand of Bezafibrate

MFCD00078970

MLS000028533

MLS001148205

MolPort-001-738-424

N/A

NCGC00016850-01

NCGC00016850-02

NCGC00016850-11

NCGC00023317-03

NCGC00023317-04

NCGC00023317-05

NCGC00023317-06

NCGC00023317-07

NCGC00023317-08

NINDS_000092

PB, Bezafibrat

Prestwick0_000378

Prestwick1_000378

Prestwick2_000378

Prestwick3_000378

Prestwick_724

Propanoic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-

Propionic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-

QA-0923

Reducterol

Regadrin B

Roche Brand of Bezafibrate

Sklerofibrat

SMR000058298

Solibay

SPBio_000824

SPBio_002456

SPECTRUM1502046

Spectrum2_000922

Spectrum3_001500

Spectrum4_000325

Spectrum5_001079

Spectrum5_001967

Spectrum_001443

ST51014927

Synthelabo Brand of Bezafibrate

TAD Brand of Bezafibrate

Teva Brand of Bezafibrate

USAN

USAN)

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.73 9.58 -55.18 1 5 -1 78 360.817 7

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.55e-03 g/l DrugBank-approved
MP 184 TCI
Therapy antihyperlipidemic SMDC Iconix
UniProt Database Links DNM1L_RAT; FABPL_LEPPA; PANK1_HUMAN; TYSD1_MOUSE ChEBI
Patent Database Links EP1258253; EP1522310; EP1553091; EP1559419; EP1655037; EP1714648; EP1723968; EP1746099; EP1782828; EP1785144; EP1832576; EP1884513; EP1889847; EP1911462; US2004073037; US2004092596; US2005009870; US2005014786; US2005080087; US2005209165; US2006154876; US2 ChEBI
Target Others Selleck Chemicals
Target PPAR Selleck Chemicals

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
PPARG-2-E Peroxisome Proliferator-activated Receptor Gamma (cluster #2 Of 2), Eukaryotic Eukaryotes 3000 0.31 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
PPARG_HUMAN P37231 Peroxisome Proliferator-activated Receptor Gamma, Human 3000 0.31 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Nuclear Receptor transcription pathway
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.