In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
October 25th, 2005 | 17 | Yes |
Popular Name: 1-BLAHylpropan-2-amine 1-BLAHylpropan-2-amine
None
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 1.99 | -2.91 | -47.7 | 4 | 3 | 1 | 52 | 231.319 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
5HT1B-1-E | Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3300 | 0.45 | Binding ≤ 10μM |
5HT1D-1-E | Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1900 | 0.47 | Binding ≤ 10μM |
5HT2A-2-E | Serotonin 2a (5-HT2a) Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 2 | 0.72 | Binding ≤ 10μM |
5HT2A-2-E | Serotonin 2a (5-HT2a) Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 4 | 0.69 | Binding ≤ 10μM |
5HT2B-1-E | Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 5 | 0.68 | Binding ≤ 10μM |
5HT2B-1-E | Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 13 | 0.65 | Binding ≤ 10μM |
5HT2C-1-E | Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3 | 0.70 | Binding ≤ 10μM |
5HT2C-1-E | Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 6 | 0.68 | Binding ≤ 10μM |
5HT4R-1-E | Serotonin 4 (5-HT4) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1700 | 0.48 | Binding ≤ 10μM |
5HT4R-1-E | Serotonin 4 (5-HT4) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1800 | 0.47 | Binding ≤ 10μM |
5HT6R-2-E | Serotonin 6 (5-HT6) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 400 | 0.53 | Binding ≤ 10μM |
5HT6R-2-E | Serotonin 6 (5-HT6) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2200 | 0.47 | Binding ≤ 10μM |
ADA2B-1-E | Alpha-2b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 10000 | 0.41 | Binding ≤ 10μM |
5HT2A-2-E | Serotonin 2a (5-HT2a) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 80 | 0.58 | Functional ≤ 10μM |
5HT2A-2-E | Serotonin 2a (5-HT2a) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 116 | 0.57 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
5HT2A_HUMAN | P28223 | Serotonin 2a (5-HT2a) Receptor, Human | 2 | 0.72 | Binding ≤ 1μM |
5HT2A_RAT | P14842 | Serotonin 2a (5-HT2a) Receptor, Rat | 0.2 | 0.80 | Binding ≤ 1μM |
5HT2B_HUMAN | P41595 | Serotonin 2b (5-HT2b) Receptor, Human | 5.3 | 0.68 | Binding ≤ 1μM |
5HT2C_HUMAN | P28335 | Serotonin 2c (5-HT2c) Receptor, Human | 3.4 | 0.70 | Binding ≤ 1μM |
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 400 | 0.53 | Binding ≤ 1μM |
ADA2B_RAT | P19328 | Alpha-2b Adrenergic Receptor, Rat | 10000 | 0.41 | Binding ≤ 10μM |
5HT1B_HUMAN | P28222 | Serotonin 1b (5-HT1b) Receptor, Human | 3300 | 0.45 | Binding ≤ 10μM |
5HT1D_HUMAN | P28221 | Serotonin 1d (5-HT1d) Receptor, Human | 1900 | 0.47 | Binding ≤ 10μM |
5HT2A_HUMAN | P28223 | Serotonin 2a (5-HT2a) Receptor, Human | 2 | 0.72 | Binding ≤ 10μM |
5HT2A_RAT | P14842 | Serotonin 2a (5-HT2a) Receptor, Rat | 0.2 | 0.80 | Binding ≤ 10μM |
5HT2B_HUMAN | P41595 | Serotonin 2b (5-HT2b) Receptor, Human | 5.3 | 0.68 | Binding ≤ 10μM |
5HT2C_HUMAN | P28335 | Serotonin 2c (5-HT2c) Receptor, Human | 3.4 | 0.70 | Binding ≤ 10μM |
5HT4R_HUMAN | Q13639 | Serotonin 4 (5-HT4) Receptor, Human | 1700 | 0.48 | Binding ≤ 10μM |
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 2200 | 0.47 | Binding ≤ 10μM |
5HT2A_RAT | P14842 | Serotonin 2a (5-HT2a) Receptor, Rat | 80.1 | 0.58 | Functional ≤ 10μM |
Description | Species |
---|---|
Adrenaline signalling through Alpha-2 adrenergic receptor | |
Adrenoceptors | |
G alpha (i) signalling events | |
G alpha (q) signalling events | |
G alpha (s) signalling events | |
G alpha (z) signalling events | |
Serotonin receptors |