UCSF

ZINC18456332

Substance Information

In ZINC since Heavy atoms Benign functionality
October 7th, 2008 31 No

Other Names:

"Adenosine 5'-triphosphate disodium salt, 98%"

((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid

beta-D-ribofuranosyl]-

10168-83-9

16488-07-6

1b38

1b39

1gz3

1gz4

1kxp

1m83

1mau

1maw

1r0x

1r10

1t44

1vjc

1vjd

1xsc

1y8p

1yid

2cbz

2e5y

2fgh

2hmu

2hmw

2j9l

2p09

2p0x

2vt3

34369-07-8

3b2q

3d2e

5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adet

5'-(Tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atri

5'-(Tetrahydrogen triphosphate) Adenosine;5'-ATP;Adenosine 5'-triphosphate;Adenosine 5'-triphosphorate;Adenosine 5'-triphosphoric acid;Adenosine triphosphate;Adenylpyrophosphorate;Adenylpyrophosphoric acid;Adephos;Adetol;Adynol;Atipi;ATP;Atriphos;Cardenos

5'-(Tetrahydrogen triphosphate) Adenosine;5'-ATP;ATP;Adenosine 5'-triphosphate;Adenosine 5'-triphosphorate;Adenosine 5'-triphosphoric acid;Adenosine triphosphate;Adenylpyrophosphorate;Adenylpyrophosphoric acid;Adephos;Adetol;Adynol;Atipi;Atriphos;Cardenos

5'-ATP

5'-ATP-Na2

5'-ATP-Na2 "14,155" 12352005

5'-Atp; 9-beta-D-Arabinofuranosyladenine 5'-triphosphate; ADENOSINE-5'-PHOSPHATE; ATP; ATP (nucleotide); Adenosine 5'-(tetrahydrogen triphosphate); Adenosine 5'-triphosphate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine, 5'-(tetrahyd

5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-ylmethoxy-hydroxy-phosphoryloxy-hydroxy-phosphoryl oxyphosphonic acid

51569-41-6

56-65-5

56-65-5; ATP; Adenosine 5'-triphosphate; C00002

56-65-5; ATP; adenosine-5'-triphosphate; adenosine-triphosphate; adenylpyrophosphate

71800-44-7

84412-18-0

896506-78-8

9-beta-D-Arabinofuranosyladenine 5'-triphosphate

987-65-5; Adenosine triphosphate disodium; Atenen (TN); D08647; Triphosadenine disodium salt

9H-purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]

9H-Purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]-

A9788C43-4BC5-46E2-8560-41C5FA7D3AA3

AC1L1LHX

AC1NUU71

Adenosin-5'-triphosphate tetrasodium salt

Adenosine 5'-(tetrahydrogen triphosphate)

Adenosine 5'-(tetrahydrogen triphosphate) 2Na salt

Adenosine 5'-(tetrahydrogen triphosphate) magnesium salt

Adenosine 5'-triphosphate

ADENOSINE 5'-TRIPHOSPHATE DISODIUM SALT

Adenosine 5'-Triphosphate Disodium Salt Hydrate

ADENOSINE 5'-TRIPHOSPHATE DISODIUM SALT TRIHYDRATE

Adenosine 5'-triphosphate disodium salt; Disodium adenosine 5'-triphosphate

adenosine 5'-triphosphate(4-)

Adenosine 5'-triphosphate, disodium salt hydrate, 98%

Adenosine 5'-triphosphoric acid

Adenosine triphosphate disodium

Adenosine Triphosphate Disodium (JAN)

Adenosine triphosphate; H4atp

Adenosine, 5'-(tetrahydrogen triphosphate)

Adenosine-5'-triphosphate

Adenosine-5'-triphosphate disodium salt

Adenosine-5'-triphosphate disodium salt hydrate

Adenosine-5'-triphosphate disodium salt hydrate, 99+%, water <10%

Adenosine-5'-Triphosphate Disodium Salt Trihydrate [987-65-5]; (ATP)

ADENOSINE-5'-TRIPHOSPHATE DISODIUM SALT TRIHYDRATE; [51963-61-2]

Adenosine-5'-triphosphate magnesium salt

Adenosine-5'-triphosphoric acid

Adenosine-5,-triphosphoric acid disodium salt

adenosine-triphosphate

Adenosinetriphosphate

Adenosini Triphosphas

Adenosintriphosphorsaeure

adenylpyrophosphate

Adenylpyrophosphoric acid

Adephos

Adetol

Adeturon; LS-186711; S-2-Aminoethyl-isothiuronium adenosine triphosphate

Ado-5'-P-P-P

Adynol

Ara-ATP

Atipi

ATP

ATP (Adenosine-Triphosphate)

ATP (disodium salt)

ATP (nucleotide)

ATP (TN); Adenosine 5'-triphosphate disodium; Adenosine triphosphate disodium hydrate (JAN); Adenosine triphosphate disodium trihydrate; D02300

ATP Na salt; ATP-Na; Adenosine 5'-(tetrahydrogen triphosphate), sodium salt; Adenosine triphosphate disodium salt; LS-15182; NaAtp; Sodium ATP; Sodium adenosine triphosphate; Sodium adenosine-5'-triphosphate

ATP(3-)

ATP(4-)

ATP; atp

Atriphos

Bio1_000406

Bio1_000895

Bio1_001384

bmse000006

Cardenosine

CHEBI:10841; CHEBI:40938; CHEBI:10789; CHEBI:2359; CHEBI:22249; CHEBI:13236

CHEBI:15422

CHEBI:30616

CHEMBL14249

CID5461108

CID5957

CPD0-1634; MgATP2

D08646

DAP000474

DB00171

EINECS 200-283-2

Fosfobion

Glucobasin

H4atp

LS-15176

LS-187725

Magnesium (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(((hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-3,4-bis(olate)

MFCD00065467

MFCD00067316

MFCD00080339

MFCD00084767

MFCD00150754

MFCD00150755

MolPort-002-533-479

Myotriphos

N/A

NA

NCGC00163309-01

nchembio.135-comp2

nchembio.143-comp2

nchembio.199-comp4

nchembio.2007.22-comp5

NChemBio.2007.9-comp27

nchembio.208-comp1

nchembio.265-comp8

nchembio.266-comp10

nchembio.94-comp18

nchembio856-comp13

Phosphobion

QA-8391

Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogentriphosphate

SS-7643

Striadyne

Triadenyl

Triphosaden

Triphosadenine

Triphosadenine (DCF)

Triphosphaden

Triphosphoric acid adenosine ester

ZINC04261765

ZINC12402864

ZINC12402865

ZINC18456332

[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

[[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.54 -2.46 -364.46 4 18 -4 290 503.15 8
Ref Reference (pH 7) -3.54 -3.61 -227.01 5 18 -3 288 504.158 8
Mid Mid (pH 6-8) -3.54 -3.61 -227.24 5 18 -3 288 504.158 8

Vendor Notes

Note Type Comments Provided By
UniProt Database Links 009L_FRG3G; 019R_FRG3G; 044L_IIV3; 055L_FRG3G; 14KD_RHOSH; 172L_IIV6; 194K_TRVSY; 1A_AMVLE; 1A_BBMV; 1A_BMV; 1A_CCMV; 1A_CMVFN; 1A_CMVII; 1A_CMVIX; 1A_CMVNT; 1A_CMVO; 1A_CMVQ; 1A_CMVY; 1A_OLV2I; 1A_PSVJ; 1A_PZSVT; 1A_TAV; 1A_TOBSV; 2OCL_HYDTT; 2OCS_HYDTT ChEBI
Mp [°C] 188 - 190 Acros Organics
ALOGPS_SOLUBILITY 4.49e+00 g/l DrugBank-nutriceuticals
PUBCHEM_PATENT_ID EP0009076A1; EP0031121A1; EP0071485A2; EP0071486A2; EP0076466A2; EP0123511A2; EP0126991A1; EP0127179A1; EP0132655A2; EP0133681A2; EP0137677A1; EP0154269A2; EP0200540A2; EP0200540B1; EP0201333A2; EP0201333B1; EP0202094A2; EP0228174A1; EP0228174B1; EP024781 IBM Patent Data
PUBCHEM_PATENT_ID EP0086053A1; EP0089240A1; EP0142125A2; EP0329184A2; EP0344795A1; EP0344795B1; EP0344807A2; EP0344807B1; EP0348688A1; EP0348688B1; EP0356196A2; EP0356196B1; EP0383803A1; EP0383803B1; EP0392377A2; EP0392377B1; EP0440699B1; EP0507870A1; EP0507870B1; EP052764 IBM Patent Data
Patent Database Links EP0953356; EP1152008; EP1386908; EP1477475; EP1520582; EP1538196; EP1586325; EP1604684; EP1607481; EP1616963; EP1666064; EP1679076; EP1723968; EP1726954; EP1745789; EP1749540; EP1749829; EP1792985; EP1840134; EP1860113; EP1865067; EP1884513; EP1889626; EP ChEBI
SOLUBILITY H2O: 50 mg/mL Indofine
Target Others Selleck Chemicals
Reactome Database Links REACT_10000; REACT_10020; REACT_10034; REACT_10049; REACT_10064; REACT_10078; REACT_10087; REACT_10101; REACT_10106; REACT_10119; REACT_1045; REACT_1078; REACT_108; REACT_1082; REACT_1094; REACT_11083; REACT_11093; REACT_11098; REACT_111034; REACT_111042 ChEBI
S phrase S24/25: Avoid contact with skin and eyes. Acros Organics

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
P2RY1-1-E P2Y Purinoceptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2 0.39 Functional ≤ 10μM
P2RY1-1-E P2Y Purinoceptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 590 0.28 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
P2RY1_RAT P49651 Purinergic Receptor P2Y1, Rat 590 0.28 Functional ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description Species
5-Phosphoribose 1-diphosphate biosynthesis
Abacavir metabolism
Abacavir transmembrane transport
ABC-family proteins mediated transport
ABCA transporters in lipid homeostasis
Acetylcholine Neurotransmitter Release Cycle
Acetylcholine regulates insulin secretion
Activated point mutants of FGFR2
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
Activated TAK1 mediates p38 MAP kinase phosphorylation
activated TAK1 mediates p38 MAPK activation
Activation of ATR in response to replication stress
Activation of BAD and translocation to mitochondria
Activation of CaMK IV
Activation of caspases through apoptosome-mediated cleavage
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Activation of NF-kappaB in B cells
Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of PKB
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of RAS in B cells
Activation of the AP-1 family of transcription factors
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub
Activation of the pre-replicative complex
Adenylate cyclase activating pathway
Adherens junctions interactions
ADP signalling through P2Y purinoceptor 1
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
alpha-linolenic acid (ALA) metabolism
Alpha-oxidation of phytanate
Amino acid synthesis and interconversion (transamination)
AMPK inhibits chREBP transcriptional activation activity
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing: Ubiquitination & Proteasome degradation
Arginine metabolism
ARMS-mediated activation
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Asymmetric localization of PCP proteins
ATM mediated phosphorylation of repair proteins
ATM mediated response to DNA double-strand break
ATP sensitive Potassium channels
Autodegradation of the E3 ubiquitin ligase COP1
Beta-catenin phosphorylation cascade
betaKlotho-mediated ligand binding
Biotin transport and metabolism
Branched-chain amino acid catabolism
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
c-src mediated regulation of Cx43 function and closure of gap junctions
Ca2+ pathway
Calmodulin induced events
CaMK IV-mediated phosphorylation of CREB
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CDK-mediated phosphorylation and removal of Cdc6
CDO in myogenesis
Cell-extracellular matrix interactions
Chk1-controlled and DNA-damage induced centrosome duplication
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Cholesterol biosynthesis
Chorismate via Shikimate Pathway
Citric acid cycle (TCA cycle)
Clearance of Nuclear Envelope Membranes from Chromatin
Cobalamin (Cbl, vitamin B12) transport and metabolism
Coenzyme A biosynthesis
Condensation of Prometaphase Chromosomes
Condensation of Prophase Chromosomes
Conjugation of benzoate with glycine
Conjugation of phenylacetate with glutamine
Conjugation of salicylate with glycine
Constitutive PI3K/AKT Signaling in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Creatine metabolism
CREB phosphorylation
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling
CTLA4 inhibitory signaling
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin B2 mediated events
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
Cytosolic tRNA aminoacylation
DAG and IP3 signaling
DAP12 signaling
DARPP-32 events
DCC mediated attractive signaling
De novo synthesis of GMP
De novo synthesis of IMP
De novo synthesis of UMP
deactivation of the beta-catenin transactivating complex
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Degradation of beta-catenin by the destruction complex
Depolymerisation of the Nuclear Lamina
Detoxification of Reactive Oxygen Species
disassembly of the destruction complex and recruitment of AXIN to the membrane
Disinhibition of SNARE formation
DNA Damage/Telomere Stress Induced Senescence
DNA replication initiation
Dopamine Neurotransmitter Release Cycle
Downregulation of ERBB2:ERBB3 signaling
Downstream signal transduction
Downstream TCR signaling
DSCAM interactions
Effects of PIP2 hydrolysis
EGFR downregulation
EGFR interacts with phospholipase C-gamma
Elevation of cytosolic Ca2+ levels
Endosomal Sorting Complex Required For Transport (ESCRT)
eNOS activation
EPH-ephrin mediated repulsion of cells
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
ER-Phagosome pathway
ERK/MAPK targets
ERK1 activation
ERK2 activation
Ethanol oxidation
Factors involved in megakaryocyte development and platelet production
Fanconi Anemia Pathway in DNA repair
Fatty Acyl-CoA Biosynthesis
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
FGFR1b ligand binding and activation
FGFR1c and Klotho ligand binding and activation
FGFR1c ligand binding and activation
FGFR2b ligand binding and activation
FGFR2c ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR4 ligand binding and activation
Folding of actin by CCT/TriC
Formation of apoptosome
Formation of ATP by chemiosmotic coupling
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of the Early Elongation Complex
Formation of tubulin folding intermediates by CCT/TriC
Frs2-mediated activation
FRS2-mediated cascade
Fructose catabolism
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
G beta:gamma signalling through PI3Kgamma
G0 and Early G1
G2 Phase
G2/M DNA damage checkpoint
G2/M DNA replication checkpoint
GAB1 signalosome
Galactose catabolism
Gastrin-CREB signalling pathway via PKC and MAPK
Generation of second messenger molecules
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Gluconeogenesis
Glucose transport
Glutathione synthesis and recycling
Glycogen breakdown (glycogenolysis)
Glycolysis
Glycosphingolipid metabolism
Golgi Associated Vesicle Biogenesis
Golgi Cisternae Pericentriolar Stack Reorganization
GPVI-mediated activation cascade
Growth hormone receptor signaling
HDL-mediated lipid transport
Hedgehog ligand biogenesis
Hh ligand biogenesis disease
Homologous DNA pairing and strand exchange
Homologous recombination repair of replication-dependent double-strand breaks
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
HSF1-dependent transactivation
HuR stabilizes mRNA
Import of palmitoyl-CoA into the mitochondrial matrix
Inactivation, recovery and regulation of the phototransduction cascade
Inhibition of TSC complex formation by PKB
Integrin alphaIIb beta3 signaling
Interaction between L1 and Ankyrins
Interferon alpha/beta signaling
Interferon gamma signaling
Interleukin receptor SHC signaling
Interleukin-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Interleukin-6 signaling
Interleukin-7 signaling
Ion transport by P-type ATPases
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
IRE1alpha activates chaperones
IRF3 mediated activation of type 1 IFN
IRF3-mediated induction of type I IFN
Iron uptake and transport
IRS activation
IRS-related events triggered by IGF1R
ISG15 antiviral mechanism
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human
Kinesins
KSRP destabilizes mRNA
L1CAM interactions
Linoleic acid (LA) metabolism
Loss of Nlp from mitotic centrosomes
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Lysosome Vesicle Biogenesis
MASTL Facilitates Mitotic Progression
Meiotic synapsis
Metabolism of folate and pterines
Methylation
MHC class II antigen presentation
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mitochondrial ABC transporters
Mitochondrial protein import
Mitochondrial tRNA aminoacylation
Molybdenum cofactor biosynthesis
mRNA 3'-end processing
Mycothiol biosynthesis
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88-dependent cascade initiated on endosome membrane
MyD88:Mal cascade initiated on plasma membrane
MyD88:TIRAP-dependent cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
NCAM1 interactions
Negative regulation of FGFR signaling
Negative regulators of RIG-I/MDA5 signaling
Nephrin interactions
Netrin mediated repulsion signals
Netrin-1 signaling
Neurofascin interactions
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
NF-kB is activated and signals survival
NFkB and MAPK activation mediated by TRAF6
NFkB activation mediated by RIP1 complexed with activated TLR3
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation
Nicotinate metabolism
NOD1/2 Signaling Pathway
Non-homologous end joining (NHEJ)
Nonhomologous End-joining (NHEJ)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Norepinephrine Neurotransmitter Release Cycle
NOTCH1 Intracellular Domain Regulates Transcription
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Nuclear Pore Complex (NPC) Disassembly
Oncogene Induced Senescence
Orc1 removal from chromatin
Oxidative Stress Induced Senescence
p130Cas linkage to MAPK signaling for integrins
P2Y receptors
p38MAPK events
p53-Independent DNA Damage Response
p75NTR recruits signalling complexes
PCP/CE pathway
PD-1 signaling
PDE3B signalling
PECAM1 interactions
PERK regulates gene expression
phospho-PLA2 pathway
Phospholipase C-mediated cascade
Phosphorylation of CD3 and TCR zeta chains
Phosphorylation of Emi1
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 com
PI-3K cascade
PI3K Cascade
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PIP3 activates AKT signaling
PKA activation
PKA activation in glucagon signalling
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Platelet degranulation
Platelet homeostasis
Platelet sensitization by LDL
PLCG1 events in ERBB2 signaling
Polo-like kinase mediated events
Polymerase switching
Polymerase switching on the C-strand of the telomere
Prolactin receptor signaling
Propionyl-CoA catabolism
Purine ribonucleoside monophosphate biosynthesis
Purine salvage
Pyrimidine biosynthesis
Pyrimidine salvage reactions
RAF activation
RAF phosphorylates MEK
Rap1 signalling
Recruitment of NuMA to mitotic centrosomes
Recycling of bile acids and salts
Recycling pathway of L1
Regulation of actin dynamics for phagocytic cup formation
Regulation of AMPK activity via LKB1
Regulation of APC/C activators between G1/S and early anaphase
Regulation of HSF1-mediated heat shock response
Regulation of insulin secretion
Regulation of KIT signaling
Regulation of PLK1 Activity at G2/M Transition
Regulation of pyruvate dehydrogenase (PDH) complex
Regulation of Rheb GTPase activity by AMPK
Regulation of signaling by CBL
Release of eIF4E
Resolution of Sister Chromatid Cohesion
Retinoid cycle disease events
Ribosomal scanning and start codon recognition
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIP-mediated NFkB activation via ZBP1
RMTs methylate histone arginines
RNA Polymerase I Chain Elongation
RNA Polymerase I Promoter Opening
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Chain Elongation
Role of Abl in Robo-Slit signaling
Role of DCC in regulating apoptosis
Role of LAT2/NTAL/LAB on calcium mobilization
Role of phospholipids in phagocytosis
Role of second messengers in netrin-1 signaling
RSK activation
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
S6K1 signalling
S6K1-mediated signalling
SCF(Skp2)-mediated degradation of p27/p21
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
Senescence-Associated Secretory Phenotype (SASP)
Serotonin Neurotransmitter Release Cycle
SHC activation
SHC-mediated cascade
SHC-related events triggered by IGF1R
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Sialic acid metabolism
Signal attenuation
Signal regulatory protein (SIRP) family interactions
Signal transduction by L1
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
Signaling by Activin
Signaling by BMP
Signaling by constitutively active EGFR
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR mutants
Signaling by FGFR1 amplification mutants
Signaling by FGFR1 fusion mutants
Signaling by FGFR2 amplification mutants
Signaling by FGFR4 mutants
Signaling by Hippo
Signaling by Insulin receptor
Signaling by Leptin
Signaling by NODAL
Signaling by PDGF
Signaling by SCF-KIT
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signalling to ERK5
Signalling to STAT3
SMAD2/3 MH2 Domain Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Smooth Muscle Contraction
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Spry regulation of FGF signaling
Stabilization of p53
STAT6-mediated induction of chemokines
Stimulation of the cell death response by PAK-2p34
Stimuli-sensing channels
STING mediated induction of host immune responses
Striated Muscle Contraction
Sulfate assimilation
Sulfur amino acid metabolism
SUMO is conjugated to E1 (UBA2:SAE1)
Synthesis and interconversion of nucleotide di- and triphosphates
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of Dolichyl-phosphate
Synthesis of IP3 and IP4 in the cytosol
Synthesis of IPs in the nucleus
Synthesis of PC
Synthesis of PE
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the late endosome membrane
Synthesis of PIPs at the plasma membrane
Synthesis of pyrophosphates in the cytosol
Synthesis of very long-chain fatty acyl-CoAs
t(4;14) translocations of FGFR3
T41 mutants of beta-catenin aren't phosphorylated
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Telomere C-strand synthesis initiation
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR1 KD Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
The canonical retinoid cycle in rods (twilight vision)
The NLRP1 inflammasome
The NLRP3 inflammasome
The proton buffering model
The tricarboxylic acid cycle
Tie2 Signaling
TRAF mediated activation of IRF
TRAF3-dependent IRF activation pathway
TRAF6 mediated induction of TAK1 complex
TRAF6 mediated induction of the anti inflammatory cytokines
TRAF6 mediated IRF7 activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated NF-kB activation
Trafficking and processing of endosomal TLR
Trafficking of AMPA receptors
Trafficking of dietary sterols
Trafficking of GluR2-containing AMPA receptors
Transcription of the HIV genome
Transcriptional activation of mitochondrial biogenesis
Transferrin endocytosis and recycling
Translocation of GLUT4 to the plasma membrane
Translocation of ZAP-70 to Immunological synapse
Transport and synthesis of PAPS
Triglyceride Biosynthesis
Tristetraprolin (TTP) destabilizes mRNA
TRKA activation by NGF
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D1
Uptake and function of anthrax toxins
Urea cycle
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
VEGFR2 mediated vascular permeability
Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1
Vitamin B1 (thiamin) metabolism
Vitamin B2 (riboflavin) metabolism
Vitamins B6 activation to pyridoxal phosphate
WNT mediated activation of DVL
WNT5A-dependent internalization of FZD4

Reactome Annotations from Targets (via Uniprot)

Description Species
ADP signalling through P2Y purinoceptor 1
G alpha (q) signalling events
P2Y receptors

Analogs ( Draw Identity 99% 90% 80% 70% )