UCSF

Serine-protein Kinase ATM, Human (22 Compounds)

Swissprot:
ATM_HUMAN
Stitch:
ATM_HUMAN
UniProt:
Q13315
ChEMBL:
CHEMBL3797
Reactome:
REACT_1924
REACT_204
REACT_20549
REACT_169185
REACT_897
REACT_27271
REACT_97
REACT_200780
REACT_18265
REACT_309
REACT_1614
PDB:
ATM

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 22 2 1 0
Binding ≤ 1μM 9 2 1 0

Reactome Network (11)

Reactome ID Description Species
REACT_1924 ATM mediated phosphorylation of repair proteins Homo sapiens
REACT_204 ATM mediated response to DNA double-strand break Homo sapiens
REACT_20549 Autodegradation of the E3 ubiquitin ligase COP1 Homo sapiens
REACT_169185 DNA Damage/Telomere Stress Induced Senescence Homo sapiens
REACT_897 G2/M DNA damage checkpoint Homo sapiens
REACT_27271 Meiotic recombination Homo sapiens
REACT_97 Recruitment of repair and signaling proteins to double-strand breaks Homo sapiens
REACT_200780 Regulation of HSF1-mediated heat shock response Homo sapiens
REACT_18265 Regulation of the Fanconi anemia pathway Homo sapiens
REACT_309 Stabilization of p53 Homo sapiens
REACT_1614 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ATR_HUMAN Q13535 CHEMBL5024 Serine-protein Kinase ATR, Human 18

Regulation of HSF1-mediated heat shock response

Uniprot Swissprot Chembl Description Number Shared
ATR_HUMAN Q13535 CHEMBL5024 Serine-protein Kinase ATR, Human 18

Regulation of the Fanconi anemia pathway

Uniprot Swissprot Chembl Description Number Shared
ATR_HUMAN Q13535 CHEMBL5024 Serine-protein Kinase ATR, Human 18

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ATM-1-E Serine-protein Kinase ATM (cluster #1 Of 2), Eukaryotic 21 1 0 0
ATM-2-E Serine-protein Kinase ATM (cluster #2 Of 2), Eukaryotic 1 1 1 0
Uniprot Swissprot Chembl Description Number Shared
ATR_HUMAN Q13535 CHEMBL5024 Serine-protein Kinase ATR, Human 18
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 16
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 1

Most Common Rings