UCSF

Cyclin T1, Human (30 Compounds)

Swissprot:
CCNT1_HUMAN
Stitch:
CCNT1_HUMAN
UniProt:
O60563
ChEMBL:
CHEMBL2108
Reactome:
REACT_22201
REACT_6346
REACT_1845
REACT_6259
REACT_6905
REACT_6244
REACT_6143
REACT_22107
REACT_833
REACT_120734
REACT_6162
REACT_6344
PDB:
2PK2 (DOCK)
3BLH (DOCK)
3BLQ (DOCK)
3BLR (DOCK)
3LQ5 (DOCK)
3MI9 (DOCK)
3MIA (DOCK)
3MY1 (DOCK)
CCNT1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 30 5 2 5
Binding ≤ 1μM 23 5 1 5

Reactome Network (12)

Reactome ID Description Species
REACT_22201 Formation of HIV elongation complex in the absence of HIV Tat Homo sapiens
REACT_6346 Formation of HIV-1 elongation complex containing HIV-1 Tat Homo sapiens
REACT_1845 Formation of RNA Pol II elongation complex Homo sapiens
REACT_6259 HIV elongation arrest and recovery Homo sapiens
REACT_6905 Interactions of Tat with host cellular proteins Homo sapiens
REACT_6244 Pausing and recovery of HIV elongation Homo sapiens
REACT_6143 Pausing and recovery of Tat-mediated HIV elongation Homo sapiens
REACT_22107 RNA Polymerase II Pre-transcription Events Homo sapiens
REACT_833 RNA Polymerase II Transcription Elongation Homo sapiens
REACT_120734 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Homo sapiens
REACT_6162 Tat-mediated elongation of the HIV-1 transcript Homo sapiens
REACT_6344 Tat-mediated HIV elongation arrest and recovery Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3

Formation of HIV-1 elongation complex containing HIV-1 Tat

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3

Formation of RNA Pol II elongation complex

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3

HIV elongation arrest and recovery

Uniprot Swissprot Chembl Description Number Shared
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29

Interactions of Tat with host cellular proteins

Uniprot Swissprot Chembl Description Number Shared
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29

Pausing and recovery of HIV elongation

Uniprot Swissprot Chembl Description Number Shared
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29

Pausing and recovery of Tat-mediated HIV elongation

Uniprot Swissprot Chembl Description Number Shared
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29

RNA Polymerase II Pre-transcription Events

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3

RNA Polymerase II Transcription Elongation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Uniprot Swissprot Chembl Description Number Shared
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29

Tat-mediated elongation of the HIV-1 transcript

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3

Tat-mediated HIV elongation arrest and recovery

Uniprot Swissprot Chembl Description Number Shared
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2 1 0 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 29
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 26
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 21
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 20
DYR1A_RAT Q63470 CHEMBL5508 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A, Rat 13
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 7
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 7
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 7
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 6
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 6
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 5
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 5
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 4
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 4
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 4
Z104296 Z104296 CHEMBL1907602 Cyclin-dependent Kinase 1/cyclin B1 4
Z104299 Z104299 CHEMBL1907605 Cyclin-dependent Kinase 2/cyclin E1 4
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 3
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 3
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 2
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 2
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 2
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 2
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 2
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 2
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 2
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 1
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 1
CCND3_HUMAN P30281 CHEMBL2422 G1/S-specific Cyclin D3, Human 1
CDC7_HUMAN O00311 CHEMBL5443 Cell Division Cycle 7-related Protein Kinase, Human 1
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
DYR1A_MOUSE Q61214 CHEMBL4750 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Mouse 1
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
INSRR_HUMAN P14616 CHEMBL5483 Insulin Receptor-related Protein, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KC1G1_HUMAN Q9HCP0 CHEMBL2426 Casein Kinase I Gamma 1, Human 1
KC1G2_HUMAN P78368 CHEMBL2543 Casein Kinase I Gamma 2, Human 1
KC1G3_HUMAN Q9Y6M4 CHEMBL5084 Casein Kinase I Isoform Gamma-3, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
KKCC2_HUMAN Q96RR4 CHEMBL5284 CaM-kinase Kinase Beta, Human 1
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
KS6B2_HUMAN Q9UBS0 CHEMBL3111 Ribosomal Protein S6 Kinase 2, Human 1
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 1
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 1
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
TAOK1_HUMAN Q7L7X3 CHEMBL5261 Serine/threonine-protein Kinase TAO1, Human 1
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
Z104295 Z104295 CHEMBL1907601 Cyclin-dependent Kinase 4/cyclin D1 1

Most Common Rings