UCSF

Cell Division Control Protein 28, Yeast (4 Compounds)

Swissprot:
CDK1_YEAST
Stitch:
CDK1_YEAST
UniProt:
P00546
ChEMBL:
CHEMBL5213
Reactome:
REACT_188908
REACT_188487
REACT_205363
REACT_224510
REACT_252897
REACT_211772
REACT_235121
REACT_189247
REACT_188488
REACT_188466
PDB:
CDC28

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 4 4 0 4
Binding ≤ 1μM 1 1 0 1

Reactome Network (10)

Reactome ID Description Species
REACT_188908 Condensation of Prometaphase Chromosomes Saccharomyces cerevisiae
REACT_188487 Cyclin A/B1 associated events during G2/M transition Saccharomyces cerevisiae
REACT_205363 Cyclin B2 mediated events Saccharomyces cerevisiae
REACT_224510 Depolymerisation of the Nuclear Lamina Saccharomyces cerevisiae
REACT_252897 E2F mediated regulation of DNA replication Saccharomyces cerevisiae
REACT_211772 E2F-enabled inhibition of pre-replication complex formation Saccharomyces cerevisiae
REACT_235121 ERK1 activation Saccharomyces cerevisiae
REACT_189247 G1/S-Specific Transcription Saccharomyces cerevisiae
REACT_188488 G2/M DNA replication checkpoint Saccharomyces cerevisiae
REACT_188466 Regulation of APC/C activators between G1/S and early anaphase Saccharomyces cerevisiae
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1,178 87 26 64
CDK1_MOUSE P11440 CHEMBL4084 Cyclin-dependent Kinase 1, Mouse 45 1 1 2

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
CDK1-1-E Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic 1,052 70 18 49
CDK1-1-F Cyclin-dependent Kinase 1 (cluster #1 Of 1), Fungal 4 4 0 4
CDK1-2-E Cyclin-dependent Kinase 1 (cluster #2 Of 4), Eukaryotic 4 0 1 0
CDK1-3-E Cyclin-dependent Kinase 1 (cluster #3 Of 4), Eukaryotic 166 21 6 15
CDK1-4-E Cyclin-dependent Kinase 1 (cluster #4 Of 4), Eukaryotic 30 3 1 3
Uniprot Swissprot Chembl Description Number Shared
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 4
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 3
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 3
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 3
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 3
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 3
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 3
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 3
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 3
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 2
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 2
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 2
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 2
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 2
Q17066_ASTPE Q17066 CHEMBL5124 Cdc2, Astpe 2
CCNB_MARGL P15206 CHEMBL4260 G2/mitotic-specific Cyclin B, Margl 1
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1
CFTR_HUMAN P13569 CHEMBL4051 Cystic Fibrosis Transmembrane Conductance Regulator, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 1
PHO85_YEAST P17157 CHEMBL5589 Cyclin-dependent Protein Kinase PHO85, Yeast 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104295 Z104295 CHEMBL1907601 Cyclin-dependent Kinase 4/cyclin D1 1