ZINC 12

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Names
Compounds (1,714)
Reactome (1)
Related By:
Pathway (0)
Organism (2)
Gene (0)
Org. Clust. (1)
ChEMBL (125)
Rings (50)

Glucocorticoid Receptor, Human (1,714 Compounds)

Swissprot:: GCR_HUMAN
Stitch:: GCR_HUMAN
UniProt:: P04150
ChEMBL:: CHEMBL2034
Reactome:: REACT_111118
PDB:: 1M2Z (DOCK); 1NHZ (DOCK); 1P93 (DOCK); 3BQD (DOCK); 3CLD (DOCK); 3E7C (DOCK); 3H52 (DOCK); 3K22 (DOCK); 3K23 (DOCK); NR3C1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,714	39	22	10
Binding ≤ 1μM	1,536	36	16	10
Functional ≤ 10μM	950	16	9	10

Reactome ID	Description	Species
REACT_111118	BMAL1:CLOCK,NPAS2 activates circadian gene expression	Homo sapiens

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GCR_MOUSE	P06537	CHEMBL3144	Glucocorticoid Receptor, Mouse	15	1	1	1
GCR_RAT	P06536	CHEMBL3368	Glucocorticoid Receptor, Rat	136	8	7	6

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
GCR-1-E	Glucocorticoid Receptor (cluster #1 Of 2), Eukaryotic	1,603	10	7	1
GCR-2-E	Glucocorticoid Receptor (cluster #2 Of 2), Eukaryotic	266	38	25	15

Uniprot	Swissprot	Chembl	Description	Number Shared
PRGR_HUMAN	P06401	CHEMBL208	Progesterone Receptor, Human	722
ANDR_HUMAN	P10275	CHEMBL1871	Androgen Receptor, Human	404
MCR_HUMAN	P08235	CHEMBL1994	Mineralocorticoid Receptor, Human	404
Z80110	Z80110	CHEMBL613507	CV-1 (Kidney Cells)	76
ESR1_HUMAN	P03372	CHEMBL206	Estrogen Receptor Alpha, Human	51
ESR2_HUMAN	Q92731	CHEMBL242	Estrogen Receptor Beta, Human	44
GCR_RAT	P06536	CHEMBL3368	Glucocorticoid Receptor, Rat	37
Z100081	Z100081	CHEMBL613107	PBMC (Peripheral Blood Mononuclear Cells)	29
Z50594	Z50594	CHEMBL375	Mus Musculus	22
Z80682	Z80682	CHEMBL392	A549 (Lung Carcinoma Cells)	22
MCR_RAT	P22199	CHEMBL3507	Mineralocorticoid Receptor, Rat	19
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	19
GCR_MOUSE	P06537	CHEMBL3144	Glucocorticoid Receptor, Mouse	16
ATTY_RAT	P04694	CHEMBL5947	Tyrosine Aminotransferase, Rat	10
GLNA_HUMAN	P15104	CHEMBL4612	Glutamine Synthetase, Human	8
NR1I2_HUMAN	O75469	CHEMBL3401	Pregnane X Receptor, Human	7
Z81011	Z81011	CHEMBL614840	Human Cell Lines	5
ANDR_MOUSE	P19091	CHEMBL3056	Androgen Receptor, Mouse	4
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	4
Z80936	Z80936	CHEMBL614818	HEK293 (Embryonic Kidney Fibroblasts)	4
Z81247	Z81247	CHEMBL399	HeLa (Cervical Adenocarcinoma Cells)	4
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	2
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	2
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	2
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	2
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	2
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
FABPL_RAT	P02692	CHEMBL5738	Fatty Acid-binding Protein, Liver, Rat	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NR1H2_HUMAN	P55055	CHEMBL4093	LXR-beta, Human	2
NR1H3_HUMAN	Q13133	CHEMBL2808	LXR-alpha, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2
PRGR_CHICK	P07812	CHEMBL3304	Progesterone Receptor, Chick	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	2
VP16_HHV11	P06492	CHEMBL4218	Alpha Trans-inducing Protein (VP16), Hhv11	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z80712	Z80712	CHEMBL614361	T47D (Breast Carcinoma Cells)	2
Z80954	Z80954	CHEMBL614071	HFF (Foreskin Fibroblasts)	2
ERG2_YEAST	P32352	CHEMBL3224	C-8 Sterol Isomerase, Yeast	1
ESR1_RAT	P06211	CHEMBL2724	Estrogen Receptor Alpha, Rat	1
ESR2_RAT	Q62986	CHEMBL3021	Estrogen Receptor Beta, Rat	1
NR1H4_HUMAN	Q96RI1	CHEMBL2047	Bile Acid Receptor FXR, Human	1
NR1H4_MOUSE	Q60641	CHEMBL5343	Bile Acid Receptor, Mouse	1
NTCP_RAT	P26435	CHEMBL4847	Bile Acid Transporter, Rat	1
O46399_SHEEP	O46399	CHEMBL3462	Beta Tubulin, Sheep	1
P96878_MYCTU	P96878	CHEMBL5767	PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE), Myctu	1
PRGR_RABIT	P06186	CHEMBL3456	Progesterone Receptor, Rabit	1
PRGR_RAT	Q63449	CHEMBL2596	Progesterone Receptor, Rat	1
Q3I4V7_CRYNV	Q3I4V7	CHEMBL1697676	Carbonic Anhydrase 2, Crynv	1
Q5AJ71_CANAL	Q5AJ71	CHEMBL5337	Carbonic Anhydrase, Canal	1
Q862F3_BOVIN	Q862F3	CHEMBL4262	Tubulin Alpha Chain, Bovin	1
Q862L2_BOVIN	Q862L2	CHEMBL3752	Tubulin Alpha-1 Chain, Bovin	1
Q9MZB0_SHEEP	Q9MZB0	CHEMBL4099	Tubulin Alpha-1 Chain, Sheep	1
S5A1_RAT	P24008	CHEMBL3422	Steroid 5-alpha-reductase 1, Rat	1
S5A2_RAT	P31214	CHEMBL5099	Steroid 5-alpha-reductase 2, Rat	1
SGMR1_CAVPO	Q60492	CHEMBL4153	Sigma-1 Receptor, Guinea Pig	1
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	1
TBA1A_HUMAN	Q71U36	CHEMBL3661	Tubulin Alpha-3 Chain, Human	1
TBA1A_PIG	P02550	CHEMBL3658	Tubulin Alpha Chain, Pig	1
TBA1A_RAT	P68370	CHEMBL4139	Tubulin Alpha-1 Chain, Rat	1
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	1
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	1
TBB2B_BOVIN	Q6B856	CHEMBL3394	Tubulin Beta Chain, Bovin	1
TBB2B_RAT	Q3KRE8	CHEMBL2984	Tubulin Beta Chain, Rat	1
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	1
TBB3_RAT	Q4QRB4	CHEMBL4569	Tubulin Beta-3 Chain, Rat	1
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	1
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	1
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin Beta-5 Chain, Human	1
TBB8_HUMAN	Q3ZCM7	CHEMBL4024	Tubulin Beta-8 Chain, Human	1
TBB_PIG	P02554	CHEMBL2788	Tubulin Beta Chain, Pig	1
TBG1_RAT	P83888	CHEMBL2881	Tubulin Gamma-1 Chain, Rat	1
THA_HUMAN	P10827	CHEMBL1860	Thyroid Hormone Receptor Alpha, Human	1
VE2_HPV1A	P03118	CHEMBL5822	Regulatory Protein E2, Hpv1a	1
Y1284_MYCTU	P64797	CHEMBL5631	Uncharacterized Protein Rv1284/MT1322, Myctu	1
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1
Z80156	Z80156	CHEMBL383	HL-60 (Promyeloblast Leukemia Cells)	1
Z80178	Z80178	CHEMBL614040	J774.A1 (Macrophage Cells)	1
Z80301	Z80301	CHEMBL613516	N9	1
Z80418	Z80418	CHEMBL612557	RAW264.7 (Monocytic-macrophage Leukemia Cells)	1
Z80491	Z80491	CHEMBL614163	SK-N-MC (Neuroepithelioma Cells)	1
Z80548	Z80548	CHEMBL614245	THP-1 (Acute Monocytic Leukemia Cells)	1
Z80951	Z80951	CHEMBL614822	NIH3T3 (Fibroblasts)	1
Z81338	Z81338	CHEMBL614309	T-cells	1