UCSF

Glycogen Synthase Kinase-3 Beta, Rat (6 Compounds)

Swissprot:
GSK3B_RAT
Stitch:
GSK3B_RAT
UniProt:
P18266
ChEMBL:
CHEMBL3669
Reactome:
REACT_252972
REACT_249104
REACT_260559
REACT_234350
REACT_198729
REACT_254909
REACT_257365
REACT_216976
REACT_237110
REACT_216489
REACT_250136
REACT_248040
REACT_251328
REACT_242544
REACT_232045
PDB:
Gsk3b

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 6 0 0 0
Binding ≤ 1μM 5 0 0 0
Functional ≤ 10μM 16 0 0 0

Reactome Network (15)

Reactome ID Description Species
REACT_252972 AKT phosphorylates targets in the cytosol Rattus norvegicus
REACT_249104 APC truncation mutants have impaired AXIN binding Rattus norvegicus
REACT_260559 AXIN missense mutants destabilize the destruction complex Rattus norvegicus
REACT_234350 Beta-catenin phosphorylation cascade Rattus norvegicus
REACT_198729 Constitutive PI3K/AKT Signaling in Cancer Rattus norvegicus
REACT_254909 CRMPs in Sema3A signaling Rattus norvegicus
REACT_257365 Degradation of beta-catenin by the destruction complex Rattus norvegicus
REACT_216976 disassembly of the destruction complex and recruitment of AXIN to the membrane Rattus norvegicus
REACT_237110 misspliced GSK3beta mutants stabilize beta-catenin Rattus norvegicus
REACT_216489 Regulation of HSF1-mediated heat shock response Rattus norvegicus
REACT_250136 S33 mutants of beta-catenin aren't phosphorylated Rattus norvegicus
REACT_248040 S37 mutants of beta-catenin aren't phosphorylated Rattus norvegicus
REACT_251328 S45 mutants of beta-catenin aren't phosphorylated Rattus norvegicus
REACT_242544 T41 mutants of beta-catenin aren't phosphorylated Rattus norvegicus
REACT_232045 truncations of AMER1 destabilize the destruction complex Rattus norvegicus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1,367 166 28 48
GSK3B_MOUSE Q9WV60 CHEMBL1075321 Glycogen Synthase Kinase-3 Beta, Mouse 1 1 0 0

Clustered By Gene (0)

Clustered By Organism (6)

Code Description Substances Purchasable Natural In Man
GSK3B-1-E Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic 1,121 117 13 36
GSK3B-2-E Glycogen Synthase Kinase-3 Beta (cluster #2 Of 7), Eukaryotic 21 14 3 0
GSK3B-3-E Glycogen Synthase Kinase-3 Beta (cluster #3 Of 7), Eukaryotic 17 13 2 0
GSK3B-4-E Glycogen Synthase Kinase-3 Beta (cluster #4 Of 7), Eukaryotic 126 4 1 5
GSK3B-5-E Glycogen Synthase Kinase-3 Beta (cluster #5 Of 7), Eukaryotic 29 2 0 0
GSK3B-6-E Glycogen Synthase Kinase-3 Beta (cluster #6 Of 7), Eukaryotic 17 7 0 0
GSK3B-7-E Glycogen Synthase Kinase-3 Beta (cluster #7 Of 7), Eukaryotic 38 10 9 8
Uniprot Swissprot Chembl Description Number Shared
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 6
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 5
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 5
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 5
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 3
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 3
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 3
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 3
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 3
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 2
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 2
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 2
CCND3_HUMAN P30281 CHEMBL2422 G1/S-specific Cyclin D3, Human 1
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KC1G1_HUMAN Q9HCP0 CHEMBL2426 Casein Kinase I Gamma 1, Human 1
KC1G2_HUMAN P78368 CHEMBL2543 Casein Kinase I Gamma 2, Human 1
Z104295 Z104295 CHEMBL1907601 Cyclin-dependent Kinase 4/cyclin D1 1