UCSF

Inositol 1,4,5-trisphosphate Receptor Type 1, Human (17 Compounds)

Swissprot:
ITPR1_HUMAN
Stitch:
ITPR1_HUMAN
UniProt:
Q14643
ChEMBL:
CHEMBL4046
Reactome:
REACT_118700
REACT_172761
REACT_23767
REACT_111064
REACT_2202
REACT_162
REACT_163834
REACT_18274
REACT_15426
REACT_18325
REACT_160158
REACT_228024
PDB:
ITPR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 17 9 7 4
Binding ≤ 1μM 15 9 7 4
Functional ≤ 10μM 8 0 0 0
Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

Ca2+ pathway

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

DAG and IP3 signaling

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

Effects of PIP2 hydrolysis

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

Elevation of cytosolic Ca2+ levels

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

FCERI mediated Ca+2 mobilization

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

PLC beta mediated events

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

Regulation of insulin secretion

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

Role of phospholipids in phagocytosis

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23

VEGFR2 mediated cell proliferation

Uniprot Swissprot Chembl Description Number Shared
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITPR1_BOVIN Q9TU34 CHEMBL2509 Inositol 1,4,5-trisphosphate Receptor Type 1, Bovin 20 8 6 5
ITPR1_RAT P29994 CHEMBL2804 Inositol 1,4,5-trisphosphate Receptor Type 1, Rat 25 5 5 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 13 9 7 4
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 20 13 9 4

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ITPR3_HUMAN Q14573 CHEMBL3904 Inositol 1,4,5-trisphosphate Receptor Type 3, Human 23
ITPR2_HUMAN Q14571 CHEMBL2512 Inositol 1,4,5-trisphosphate Receptor Type 2, Human 21
ITPR1_BOVIN Q9TU34 CHEMBL2509 Inositol 1,4,5-trisphosphate Receptor Type 1, Bovin 8
ITPR2_BOVIN Q8WN96 CHEMBL3112 Inositol 1,4,5-trisphosphate Receptor Type 2, Bovin 8
ITPR3_BOVIN Q8WN95 CHEMBL2853 Inositol 1,4,5-trisphosphate Receptor Type 3, Bovin 8
ITPR1_RAT P29994 CHEMBL2804 Inositol 1,4,5-trisphosphate Receptor Type 1, Rat 5
ITPR2_RAT P29995 CHEMBL2537 Inositol 1,4,5-trisphosphate Receptor Type 2, Rat 5
ITPR3_RAT Q63269 CHEMBL2846 Inositol 1,4,5-trisphosphate Receptor Type 3, Rat 5
IP3KA_RAT P17105 CHEMBL3261 Inositol-trisphosphate 3-kinase A, Rat 4
IP3KB_RAT P42335 CHEMBL3307 Inositol-trisphosphate 3-kinase B, Rat 4
IP3KC_RAT Q80ZG2 CHEMBL2667 Inositol 1,4,5-trisphosphate 3 Kinase C, Rat 4
P79248_PIG P79248 CHEMBL2950 Type 1 InsP3 Receptor Isoform S2, Pig 4
PLCL1_RAT Q62688 CHEMBL3364 Inositol 1,4,5-trisphosphate Binding Protein, Rat 4
Z50591 Z50591 CHEMBL613489 Bos Taurus 1