UCSF

Tyrosine-protein Kinase LCK, Mouse (85 Compounds)

Swissprot:
LCK_MOUSE
Stitch:
LCK_MOUSE
UniProt:
P06240
ChEMBL:
CHEMBL2480
Reactome:
REACT_204081
REACT_226151
REACT_261451
REACT_196588
REACT_261568
REACT_188185
REACT_225145
REACT_225768
REACT_220092
REACT_261365
REACT_263643
REACT_216080
REACT_226341
REACT_227425
REACT_188578
REACT_215414
PDB:
Lck

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 85 9 1 3
Binding ≤ 1μM 54 8 1 3
Functional ≤ 10μM 1 0 0 0

Reactome Network (16)

Reactome ID Description Species
REACT_204081 CD28 co-stimulation Mus musculus
REACT_226151 CD28 dependent PI3K/Akt signaling Mus musculus
REACT_261451 CD28 dependent Vav1 pathway Mus musculus
REACT_196588 Constitutive PI3K/AKT Signaling in Cancer Mus musculus
REACT_261568 CTLA4 inhibitory signaling Mus musculus
REACT_188185 DAP12 signaling Mus musculus
REACT_225145 Downstream TCR signaling Mus musculus
REACT_225768 Generation of second messenger molecules Mus musculus
REACT_220092 GPVI-mediated activation cascade Mus musculus
REACT_261365 Interleukin-2 signaling Mus musculus
REACT_263643 PD-1 signaling Mus musculus
REACT_216080 Phosphorylation of CD3 and TCR zeta chains Mus musculus
REACT_226341 PIP3 activates AKT signaling Mus musculus
REACT_227425 Regulation of KIT signaling Mus musculus
REACT_188578 Signaling by SCF-KIT Mus musculus
REACT_215414 Translocation of ZAP-70 to Immunological synapse Mus musculus
Uniprot Swissprot Chembl Description Number Shared
CSK_MOUSE P41241 CHEMBL2333 Tyrosine-protein Kinase CSK, Mouse 13

Phosphorylation of CD3 and TCR zeta chains

Uniprot Swissprot Chembl Description Number Shared
CSK_MOUSE P41241 CHEMBL2333 Tyrosine-protein Kinase CSK, Mouse 13
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1,382 96 26 48

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
LCK-1-E Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic 1,333 71 18 44
LCK-2-E Tyrosine-protein Kinase LCK (cluster #2 Of 4), Eukaryotic 0 0 0 0
LCK-3-E Tyrosine-protein Kinase LCK (cluster #3 Of 4), Eukaryotic 106 27 7 3
LCK-4-E Tyrosine-protein Kinase LCK (cluster #4 Of 4), Eukaryotic 1 1 1 1
Uniprot Swissprot Chembl Description Number Shared
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 37
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 21
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 19
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 18
CSK_MOUSE P41241 CHEMBL2333 Tyrosine-protein Kinase CSK, Mouse 13
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 8
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 7
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 6
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 6
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 5
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 5
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 5
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 5
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 5
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 5
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 4
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 4
BTK_HUMAN Q06187 CHEMBL5251 Tyrosine-protein Kinase BTK, Human 4
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 4
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 4
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 4
BLK_MOUSE P16277 CHEMBL3343 Tyrosine-protein Kinase BLK, Mouse 3
BRSK2_HUMAN Q8IWQ3 CHEMBL4574 BR Serine/threonine-protein Kinase 2, Human 3
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 3
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 3
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 3
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 3
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 2
BMX_HUMAN P51813 CHEMBL3834 Tyrosine-protein Kinase BMX, Human 2
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 2
DYRK3_HUMAN O43781 CHEMBL4575 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Human 2
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 2
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 2
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 2
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 2
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 2
EPHB3_HUMAN P54753 CHEMBL4901 Ephrin Type-B Receptor 3, Human 2
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 2
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 2
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 2
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 2
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 2
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 2
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 2
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 2
Q9BJF5_TOXGO Q9BJF5 CHEMBL1781862 Calmodulin-domain Protein Kinase 1, Toxgo 2
SGK1_HUMAN O00141 CHEMBL2343 Serine/threonine-protein Kinase Sgk1, Human 2
AAPK1_RAT P54645 CHEMBL4533 AMP-activated Protein Kinase, Alpha-1 Subunit, Rat 1
AAPK2_RAT Q09137 CHEMBL4637 AMP-activated Protein Kinase, Alpha-2 Subunit, Rat 1
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 1
ACK1_HUMAN Q07912 CHEMBL4599 Tyrosine Kinase Non-receptor Protein 2, Human 1
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 1
ACVL1_HUMAN P37023 CHEMBL5311 Serine/threonine-protein Kinase Receptor R3, Human 1
ACVR1_HUMAN Q04771 CHEMBL5903 Activin Receptor Type-1, Human 1
ADCK3_HUMAN Q8NI60 CHEMBL5550 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 1
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 1
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 1
AVR2A_HUMAN P27037 CHEMBL5616 Activin Receptor Type-2A, Human 1
AVR2B_HUMAN Q13705 CHEMBL5466 Activin Receptor Type-2B, Human 1
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 1
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 1
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 1
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 1
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 1
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 1
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 1
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 1
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 1
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 1
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 1
HSPB1_HUMAN P04792 CHEMBL5976 Heat Shock Protein Beta-1, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
KS6A3_HUMAN P51812 CHEMBL2345 Ribosomal Protein S6 Kinase Alpha 3, Human 1
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 1
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 1
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 1
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 1
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 1
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 1
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PMYT1_HUMAN Q99640 CHEMBL3984 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
SIK1_HUMAN P57059 CHEMBL6082 Serine/threonine-protein Kinase SIK1, Human 1
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 1
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 1
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 1
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 1
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 1
STK3_HUMAN Q13188 CHEMBL4708 Serine/threonine-protein Kinase MST2, Human 1
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 1
TEC_HUMAN P42680 CHEMBL4246 Tyrosine-protein Kinase TEC, Human 1
TESK1_HUMAN Q15569 CHEMBL5604 Dual Specificity Testis-specific Protein Kinase 1, Human 1
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 1
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 1
TYRO3_HUMAN Q06418 CHEMBL5314 Tyrosine-protein Kinase Receptor TYRO3, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1

Most Common Rings