UCSF

Melanocortin Receptor 4, Human (2,290 Compounds)

Swissprot:
MC4R_HUMAN
Stitch:
MC4R_HUMAN
UniProt:
P32245
ChEMBL:
CHEMBL259
Reactome:
REACT_19327
REACT_14819
PDB:
2IQP (DOCK)
2IQR (DOCK)
2IQS (DOCK)
2IQU (DOCK)
2IQV (DOCK)
2IQW (DOCK)
MC4R

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,290 5 0 0
Binding ≤ 1μM 1,923 3 0 0
Functional ≤ 10μM 756 0 0 0

Reactome Network (2)

Uniprot Swissprot Chembl Description Number Shared
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
MC3R_HUMAN P41968 CHEMBL4644 Melanocortin Receptor 3, Human 408
MC5R_HUMAN P33032 CHEMBL4608 Melanocortin Receptor 5, Human 345
MSHR_HUMAN Q01726 CHEMBL3795 Melanocortin Receptor 1, Human 274

Peptide ligand-binding receptors

Uniprot Swissprot Chembl Description Number Shared
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 7
MC3R_HUMAN P41968 CHEMBL4644 Melanocortin Receptor 3, Human 408
MC5R_HUMAN P33032 CHEMBL4608 Melanocortin Receptor 5, Human 345
MSHR_HUMAN Q01726 CHEMBL3795 Melanocortin Receptor 1, Human 274
NMUR1_HUMAN Q9HB89 CHEMBL1075178 Neuromedin-U Receptor 1, Human 4
NMUR2_HUMAN Q9GZQ4 CHEMBL1075144 Neuromedin-U Receptor 2, Human 4
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MC4R_MOUSE P56450 CHEMBL3719 Melanocortin Receptor 4, Mouse 39 0 0 0
MC4R_RAT P70596 CHEMBL2700 Melanocortin Receptor 4, Rat 9 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MC3R_HUMAN P41968 CHEMBL4644 Melanocortin Receptor 3, Human 407
MC5R_HUMAN P33032 CHEMBL4608 Melanocortin Receptor 5, Human 345
MSHR_HUMAN Q01726 CHEMBL3795 Melanocortin Receptor 1, Human 273
MSHR_MOUSE Q01727 CHEMBL4077 Melanocortin Receptor 1, Mouse 127
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 30
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 30
MC4R_MOUSE P56450 CHEMBL3719 Melanocortin Receptor 4, Mouse 15
Z81011 Z81011 CHEMBL614840 Human Cell Lines 15
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 14
MC4R_RAT P70596 CHEMBL2700 Melanocortin Receptor 4, Rat 12
Z50594 Z50594 CHEMBL375 Mus Musculus 10
MTR1B_HUMAN P49286 CHEMBL1946 Melatonin Receptor 1B, Human 9
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 8
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 8
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 8
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 7
MC3R_MOUSE P33033 CHEMBL4774 Melanocortin Receptor 3, Mouse 6
MC3R_RAT P32244 CHEMBL4023 Melanocortin Receptor 3, Rat 4
NMUR1_HUMAN Q9HB89 CHEMBL1075178 Neuromedin-U Receptor 1, Human 4
NMUR2_HUMAN Q9GZQ4 CHEMBL1075144 Neuromedin-U Receptor 2, Human 4
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 2
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC5R_MOUSE P41149 CHEMBL4489 Melanocortin Receptor 5, Mouse 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
MC5R_RAT P35345 CHEMBL2701 Melanocortin Receptor 5, Rat 1
Z80236 Z80236 CHEMBL614332 MCR (Frog Skin Melanocyte Cells) 1