P53-binding Protein Mdm-2, Human (176 Compounds)

Swissprot:: MDM2_HUMAN
Stitch:: MDM2_HUMAN
UniProt:: Q00987
ChEMBL:: CHEMBL5023
Reactome:: REACT_12564; REACT_147727; REACT_169325; REACT_169436; REACT_309; REACT_18307
PDB:: 1RV1 (DOCK); 1T4E (DOCK); 1T4F (DOCK); 1YCR (DOCK); 1Z1M (DOCK); 2AXI (DOCK); 2C6A (DOCK); 2C6B (DOCK); 2F1Y (DOCK); 2FOP (DOCK); 2GV2 (DOCK); 2HDP (DOCK); 2VJE (DOCK); 2VJF (DOCK); 3EQS (DOCK); 3G03 (DOCK); 3IUX (DOCK); 3IWY (DOCK); 3JZK (DOCK); 3JZR (DOCK); 3JZS (DOCK); 3LBK (DOCK); 3LBL (DOCK); 3LNJ (DOCK); 3LNZ (DOCK); 3TU1 (DOCK); 3V3B (DOCK); MDM2

Annotation Type	Substances	Purchasable
Binding ≤ 10μM	176	3
Binding ≤ 1μM	77	3
Functional ≤ 10μM	8	1

Reactome ID	Description	Species
REACT_12564	AKT phosphorylates targets in the cytosol	Homo sapiens
REACT_147727	Constitutive PI3K/AKT Signaling in Cancer	Homo sapiens
REACT_169325	Oncogene Induced Senescence	Homo sapiens
REACT_169436	Oxidative Stress Induced Senescence	Homo sapiens
REACT_309	Stabilization of p53	Homo sapiens
REACT_18307	Trafficking of AMPA receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
P53_HUMAN	P04637	CHEMBL4096	Cellular Tumor Antigen P53, Human	1

Uniprot	Swissprot	Chembl	Description	Number Shared
P53_HUMAN	P04637	CHEMBL4096	Cellular Tumor Antigen P53, Human	1

Uniprot	Swissprot	Chembl	Description	Number Shared
P53_HUMAN	P04637	CHEMBL4096	Cellular Tumor Antigen P53, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MDM4_HUMAN	O15151	CHEMBL1255126	Protein Mdm4, Human	0	0	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
Z104305	Z104305	CHEMBL1907611	Tumour Suppressor P53/oncoprotein Mdm2	8
Z80224	Z80224	CHEMBL387	MCF7 (Breast Carcinoma Cells)	5
Z81170	Z81170	CHEMBL612518	LNCaP (Prostate Carcinoma)	3
Z81252	Z81252	CHEMBL400	MDA-MB-231 (Breast Adenocarcinoma Cells)	3
P53_HUMAN	P04637	CHEMBL4096	Cellular Tumor Antigen P53, Human	1
Z80928	Z80928	CHEMBL394	HCT-116 (Colon Carcinoma Cells)	1