UCSF

P53-binding Protein Mdm-2, Human (176 Compounds)

Swissprot:
MDM2_HUMAN
Stitch:
MDM2_HUMAN
UniProt:
Q00987
ChEMBL:
CHEMBL5023
Reactome:
REACT_12564
REACT_147727
REACT_169325
REACT_169436
REACT_309
REACT_18307
PDB:
1RV1 (DOCK)
1T4E (DOCK)
1T4F (DOCK)
1YCR (DOCK)
1Z1M (DOCK)
2AXI (DOCK)
2C6A (DOCK)
2C6B (DOCK)
2F1Y (DOCK)
2FOP (DOCK)
2GV2 (DOCK)
2HDP (DOCK)
2VJE (DOCK)
2VJF (DOCK)
3EQS (DOCK)
3G03 (DOCK)
3IUX (DOCK)
3IWY (DOCK)
3JZK (DOCK)
3JZR (DOCK)
3JZS (DOCK)
3LBK (DOCK)
3LBL (DOCK)
3LNJ (DOCK)
3LNZ (DOCK)
3TU1 (DOCK)
3V3B (DOCK)
MDM2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 176 3 0 0
Binding ≤ 1μM 77 3 0 0
Functional ≤ 10μM 8 1 0 0
Uniprot Swissprot Chembl Description Number Shared
P53_HUMAN P04637 CHEMBL4096 Cellular Tumor Antigen P53, Human 1

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
P53_HUMAN P04637 CHEMBL4096 Cellular Tumor Antigen P53, Human 1

Stabilization of p53

Uniprot Swissprot Chembl Description Number Shared
P53_HUMAN P04637 CHEMBL4096 Cellular Tumor Antigen P53, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MDM4_HUMAN O15151 CHEMBL1255126 Protein Mdm4, Human 0 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
Z104305 Z104305 CHEMBL1907611 Tumour Suppressor P53/oncoprotein Mdm2 8
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 5
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 3
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 3
P53_HUMAN P04637 CHEMBL4096 Cellular Tumor Antigen P53, Human 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1