UCSF

Mitogen-activated Protein Kinase 1, Rat (8 Compounds)

Swissprot:
MK01_RAT
Stitch:
MK01_RAT
UniProt:
P63086
ChEMBL:
CHEMBL5233
Reactome:
REACT_259173
REACT_196231
REACT_196391
REACT_254856
REACT_240952
REACT_253470
REACT_195202
REACT_195028
REACT_239163
REACT_196425
REACT_251180
REACT_198995
REACT_215142
REACT_203770
REACT_262403
REACT_262886
REACT_196755
REACT_216489
REACT_196390
REACT_194748
REACT_230341
REACT_222166
REACT_262448
PDB:
1ERK (DOCK)
1GOL (DOCK)
2ERK (DOCK)
2FYS (DOCK)
2GPH (DOCK)
2Z7L (DOCK)
3C9W (DOCK)
3ERK (DOCK)
3O71 (DOCK)
3QYW (DOCK)
3QYZ (DOCK)
3R63 (DOCK)
4ERK (DOCK)
Mapk1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 0 0 0
Binding ≤ 1μM 1 0 0 0

Reactome Network (23)

Reactome ID Description Species
REACT_259173 Activation of the AP-1 family of transcription factors Rattus norvegicus
REACT_196231 Advanced glycosylation endproduct receptor signaling Rattus norvegicus
REACT_196391 CREB phosphorylation through the activation of Ras Rattus norvegicus
REACT_254856 ERK/MAPK targets Rattus norvegicus
REACT_240952 ERK2 activation Rattus norvegicus
REACT_253470 ERKs are inactivated Rattus norvegicus
REACT_195202 FCERI mediated MAPK activation Rattus norvegicus
REACT_195028 Gastrin-CREB signalling pathway via PKC and MAPK Rattus norvegicus
REACT_239163 Golgi Cisternae Pericentriolar Stack Reorganization Rattus norvegicus
REACT_196425 Growth hormone receptor signaling Rattus norvegicus
REACT_251180 NCAM signaling for neurite out-growth Rattus norvegicus
REACT_198995 Negative regulation of FGFR signaling Rattus norvegicus
REACT_215142 Oncogene Induced Senescence Rattus norvegicus
REACT_203770 Oxidative Stress Induced Senescence Rattus norvegicus
REACT_262403 phospho-PLA2 pathway Rattus norvegicus
REACT_262886 Recycling pathway of L1 Rattus norvegicus
REACT_196755 Regulation of actin dynamics for phagocytic cup formation Rattus norvegicus
REACT_216489 Regulation of HSF1-mediated heat shock response Rattus norvegicus
REACT_196390 RSK activation Rattus norvegicus
REACT_194748 Senescence-Associated Secretory Phenotype (SASP) Rattus norvegicus
REACT_230341 Signal transduction by L1 Rattus norvegicus
REACT_222166 Signaling by FGFR Rattus norvegicus
REACT_262448 Thrombin signalling through proteinase activated receptors (PARs) Rattus norvegicus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 135 27 9 14
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MK08_RAT P49185 CHEMBL5718 Mitogen-activated Protein Kinase 8, Rat 11 0 0 0
MK10_RAT P49187 CHEMBL4092 C-Jun N-terminal Kinase 3, Rat 55 0 0 0
MK14_RAT P70618 CHEMBL4825 MAP Kinase P38 Alpha, Rat 55 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
DYR1A_RAT Q63470 CHEMBL5508 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A, Rat 8
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 2