UCSF

Matrix Metalloproteinase 8, Human (980 Compounds)

Swissprot:
MMP8_HUMAN
Stitch:
MMP8_HUMAN
UniProt:
P22894
ChEMBL:
CHEMBL4588
Reactome:
REACT_118682
REACT_150401
REACT_118572
PDB:
1A85 (DOCK)
1A86 (DOCK)
1BZS (DOCK)
1I73 (DOCK)
1I76 (DOCK)
1JAN (DOCK)
1JAO (DOCK)
1JAP (DOCK)
1JAQ (DOCK)
1JH1 (DOCK)
1JJ9 (DOCK)
1KBC (DOCK)
1MMB (DOCK)
1MNC (DOCK)
1ZP5 (DOCK)
1ZS0 (DOCK)
1ZVX (DOCK)
2OY2 (DOCK)
2OY4 (DOCK)
3DNG (DOCK)
3DPE (DOCK)
3DPF (DOCK)
MMP8

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 980 16 6 25
Binding ≤ 1μM 855 12 6 22

Reactome Network (3)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 67
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 68
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 434
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 198
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 35
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 402
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 641
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 534
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 119
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 610

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 3
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 32
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 67
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 68
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 83
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 434
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 198
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 402
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 641
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 534
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 119
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 610

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 3
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 2
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 15
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 10
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 4
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 67
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 68
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 83
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 434
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 198
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 402
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 641
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 534
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 119
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 610
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP8_RAT O88766 CHEMBL2312 Matrix Metalloproteinase 8, Rat 11 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
MMP8-1-E Matrix Metalloproteinase 8 (cluster #1 Of 4), Eukaryotic 615 7 6 16
MMP8-2-E Matrix Metalloproteinase 8 (cluster #2 Of 4), Eukaryotic 5 0 0 0
MMP8-3-E Matrix Metalloproteinase 8 (cluster #3 Of 4), Eukaryotic 111 4 0 3
MMP8-4-E Matrix Metalloproteinase 8 (cluster #4 Of 4), Eukaryotic 345 6 1 7
Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 641
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 610
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 534
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 434
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 402
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 198
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 119
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 83
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 68
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 67
MMP11_MOUSE Q02853 CHEMBL3412 Matrix Metalloproteinase 11, Mouse 65
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 56
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 51
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 45
COLA_CLOPE P43153 CHEMBL2802 Microbial Collagenase, Clope 36
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 35
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 29
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 15
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 11
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 11
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 10
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 7
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 7
AMP1_PLAFQ O96935 CHEMBL4117 Zinc Aminopeptidase, Plafq 6
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 4
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 3
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 2
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 2
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 2
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
ATS4_BOVIN Q9TT93 CHEMBL3874 ADAMTS4, Bovin 1
DEF1A_ARATH Q9FV53 CHEMBL1075041 Peptide Deformylase 1A, Chloroplastic, Arath 1
DEFM_HUMAN Q9HBH1 CHEMBL4647 Peptide Deformylase Mitochondrial, Human 1
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 1
DEF_STAAM P68825 CHEMBL2367 Peptide Deformylase, Staam 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 1
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 1
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP8_RAT O88766 CHEMBL2312 Matrix Metalloproteinase 8, Rat 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1
MMP9_RAT P50282 CHEMBL3870 Matrix Metalloproteinase 9, Rat 1
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q9JN24_ECOLX Q9JN24 CHEMBL1795101 Peptide Deformylase, Ecolx 1
TIMP3_RAT P48032 CHEMBL3881 Tissue Inhibitor Of Metalloproteinases-3, Rat 1
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 1

Most Common Rings