UCSF

Dual Specificity Mitogen-activated Protein Kinase Kinase 7, Human (1 Compounds)

Swissprot:
MP2K7_HUMAN
Stitch:
MP2K7_HUMAN
UniProt:
O14733
ChEMBL:
CHEMBL3530
Reactome:
REACT_163701
REACT_21368
REACT_169436
REACT_228255
PDB:
2DYL (DOCK)
MAP2K7

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1 0 0 0
Binding ≤ 1μM 1 0 0 0

Reactome Network (4)

Reactome ID Description Species
REACT_163701 FCERI mediated MAPK activation Homo sapiens
REACT_21368 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human Homo sapiens
REACT_169436 Oxidative Stress Induced Senescence Homo sapiens
REACT_228255 Uptake and function of anthrax toxins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 1

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human

Uniprot Swissprot Chembl Description Number Shared
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 1

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 1

Uptake and function of anthrax toxins

Uniprot Swissprot Chembl Description Number Shared
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 463 35 15 12
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 39 20 7 9
MP2K3_HUMAN P46734 CHEMBL2109 Dual Specificity Mitogen-activated Protein Kinase Kinase 3, Human 2 2 1 1
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 7 6 2 3
MP2K5_HUMAN Q13163 CHEMBL4948 Dual Specificity Mitogen-activated Protein Kinase Kinase 5, Human 1 0 0 0
MP2K6_HUMAN P52564 CHEMBL2171 Dual Specificity Mitogen-activated Protein Kinase Kinase 6, Human 7 6 2 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 1