UCSF

Phospholipase C-gamma-1, Human (2 Compounds)

Swissprot:
PLCG1_HUMAN
Stitch:
PLCG1_HUMAN
UniProt:
P19174
ChEMBL:
CHEMBL3964
Reactome:
REACT_118700
REACT_111064
REACT_147814
REACT_17025
REACT_12478
REACT_163834
REACT_163701
REACT_12076
REACT_12623
REACT_115831
REACT_12519
REACT_21310
REACT_12079
REACT_115720
REACT_160158
REACT_22228
REACT_115852
REACT_121398
REACT_121141
REACT_150312
REACT_228024
PDB:
1HSQ (DOCK)
2HSP (DOCK)
PLCG1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2 1 1 0
Binding ≤ 1μM 0 0 0 0

Reactome Network (21)

Reactome ID Description Species
REACT_118700 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge Homo sapiens
REACT_111064 DAG and IP3 signaling Homo sapiens
REACT_147814 DAP12 signaling Homo sapiens
REACT_17025 Downstream signal transduction Homo sapiens
REACT_12478 EGFR interacts with phospholipase C-gamma Homo sapiens
REACT_163834 FCERI mediated Ca+2 mobilization Homo sapiens
REACT_163701 FCERI mediated MAPK activation Homo sapiens
REACT_12076 Frs2-mediated activation Homo sapiens
REACT_12623 Generation of second messenger molecules Homo sapiens
REACT_115831 ISG15 antiviral mechanism Homo sapiens
REACT_12519 PECAM1 interactions Homo sapiens
REACT_21310 Phospholipase C-mediated cascade Homo sapiens
REACT_12079 PLC-gamma1 signalling Homo sapiens
REACT_115720 PLCG1 events in ERBB2 signaling Homo sapiens
REACT_160158 Role of phospholipids in phagocytosis Homo sapiens
REACT_22228 Role of second messengers in netrin-1 signaling Homo sapiens
REACT_115852 Signaling by constitutively active EGFR Homo sapiens
REACT_121398 Signaling by FGFR mutants Homo sapiens
REACT_121141 Signaling by FGFR1 fusion mutants Homo sapiens
REACT_150312 Synthesis of IP3 and IP4 in the cytosol Homo sapiens
REACT_228024 VEGFR2 mediated cell proliferation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1

DAP12 signaling

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1

Downstream signal transduction

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1

FCERI mediated Ca+2 mobilization

Uniprot Swissprot Chembl Description Number Shared
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1

FCERI mediated MAPK activation

Uniprot Swissprot Chembl Description Number Shared
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1

Generation of second messenger molecules

Uniprot Swissprot Chembl Description Number Shared
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1

PECAM1 interactions

Uniprot Swissprot Chembl Description Number Shared
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1

Role of phospholipids in phagocytosis

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1

Signaling by constitutively active EGFR

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1

Signaling by FGFR mutants

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1

Signaling by FGFR1 fusion mutants

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1

Synthesis of IP3 and IP4 in the cytosol

Uniprot Swissprot Chembl Description Number Shared
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PLCG1_BOVIN P08487 CHEMBL5566 1-phosphatidylinositol-4,5-bisphosphate Phosphodiesterase Gamma-1, Bovin 4 0 2 0
PLCG1_RAT P10686 CHEMBL5188 1-phosphatidylinositol-4,5-bisphosphate Phosphodiesterase Gamma-1, Rat 1 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 22 15 6 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 1