UCSF

Proteasome Macropain Subunit, Human (7 Compounds)

Swissprot:
PSB2_HUMAN
Stitch:
PSB2_HUMAN
UniProt:
P49721
ChEMBL:
CHEMBL3492
Reactome:
REACT_118656
REACT_75842
REACT_6871
REACT_6761
REACT_172638
REACT_25325
REACT_6785
REACT_20549
REACT_1221
REACT_1949
REACT_111056
REACT_200766
REACT_11063
REACT_200841
REACT_111178
REACT_228111
REACT_228209
REACT_1156
REACT_13464
REACT_13565
REACT_9003
REACT_6821
REACT_150471
REACT_1614
REACT_4
REACT_9453
REACT_9031
PDB:
PSMB2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 7 0 0 0
Binding ≤ 1μM 5 0 0 0

Reactome Network (27)

Reactome ID Description Species
REACT_118656 Activation of NF-kappaB in B cells Homo sapiens
REACT_75842 Antigen processing: Ubiquitination & Proteasome degradation Homo sapiens
REACT_6871 APC/C:Cdc20 mediated degradation of Securin Homo sapiens
REACT_6761 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins Homo sapiens
REACT_172638 Asymmetric localization of PCP proteins Homo sapiens
REACT_25325 AUF1 (hnRNP D0) destabilizes mRNA Homo sapiens
REACT_6785 Autodegradation of Cdh1 by Cdh1:APC/C Homo sapiens
REACT_20549 Autodegradation of the E3 ubiquitin ligase COP1 Homo sapiens
REACT_1221 CDK-mediated phosphorylation and removal of Cdc6 Homo sapiens
REACT_1949 CDT1 association with the CDC6:ORC:origin complex Homo sapiens
REACT_111056 Cross-presentation of soluble exogenous antigens (endosomes) Homo sapiens
REACT_200766 degradation of AXIN Homo sapiens
REACT_11063 Degradation of beta-catenin by the destruction complex Homo sapiens
REACT_200841 degradation of DVL Homo sapiens
REACT_111178 ER-Phagosome pathway Homo sapiens
REACT_228111 Hedgehog ligand biogenesis Homo sapiens
REACT_228209 Hh ligand biogenesis disease Homo sapiens
REACT_1156 Orc1 removal from chromatin Homo sapiens
REACT_13464 Regulation of activated PAK-2p34 by proteasome mediated degradation Homo sapiens
REACT_13565 Regulation of ornithine decarboxylase (ODC) Homo sapiens
REACT_9003 SCF(Skp2)-mediated degradation of p27/p21 Homo sapiens
REACT_6821 SCF-beta-TrCP mediated degradation of Emi1 Homo sapiens
REACT_150471 Separation of Sister Chromatids Homo sapiens
REACT_1614 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Homo sapiens
REACT_4 Ubiquitin-dependent degradation of Cyclin D1 Homo sapiens
REACT_9453 Vif-mediated degradation of APOBEC3G Homo sapiens
REACT_9031 Vpu mediated degradation of CD4 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Antigen processing: Ubiquitination & Proteasome degradation

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

APC/C:Cdc20 mediated degradation of Securin

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Asymmetric localization of PCP proteins

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

AUF1 (hnRNP D0) destabilizes mRNA

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Autodegradation of Cdh1 by Cdh1:APC/C

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Autodegradation of the E3 ubiquitin ligase COP1

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

CDK-mediated phosphorylation and removal of Cdc6

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

CDT1 association with the CDC6:ORC:origin complex

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Cross-presentation of soluble exogenous antigens (endosomes)

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

degradation of AXIN

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Degradation of beta-catenin by the destruction complex

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

degradation of DVL

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

ER-Phagosome pathway

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Hedgehog ligand biogenesis

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Hh ligand biogenesis disease

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Orc1 removal from chromatin

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Regulation of activated PAK-2p34 by proteasome mediated degradation

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Regulation of ornithine decarboxylase (ODC)

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

SCF(Skp2)-mediated degradation of p27/p21

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

SCF-beta-TrCP mediated degradation of Emi1

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Separation of Sister Chromatids

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Ubiquitin-dependent degradation of Cyclin D1

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Vif-mediated degradation of APOBEC3G

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7

Vpu mediated degradation of CD4

Uniprot Swissprot Chembl Description Number Shared
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1 0 0 0
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 45 0 0 0
PSB8_HUMAN P28062 CHEMBL5620 Proteasome Subunit Beta Type-8, Human 11 0 0 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 7
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1

Most Common Rings