UCSF

Retinoblastoma-associated Protein, Human (3 Compounds)

Swissprot:
RB_HUMAN
Stitch:
RB_HUMAN
UniProt:
P06400
ChEMBL:
CHEMBL5288
Reactome:
REACT_172744
REACT_9029
REACT_821
REACT_1574
REACT_169121
REACT_329
REACT_1156
REACT_308
PDB:
1AD6 (DOCK)
1GH6 (DOCK)
1GUX (DOCK)
1H25 (DOCK)
1N4M (DOCK)
1O9K (DOCK)
1PJM (DOCK)
2AZE (DOCK)
2QDJ (DOCK)
2R7G (DOCK)
3N5U (DOCK)
3POM (DOCK)
RB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 3 0 0 0
Binding ≤ 1μM 3 0 0 0
Uniprot Swissprot Chembl Description Number Shared
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1

Cyclin A:Cdk2-associated events at S phase entry

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3

Cyclin D associated events in G1

Uniprot Swissprot Chembl Description Number Shared
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 3

Cyclin E associated events during G1/S transition

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3

Orc1 removal from chromatin

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3

Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
RBBP9_HUMAN O75884 CHEMBL1075121 Putative Hydrolase RBBP9, Human 7 7 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 3
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
STAT3_HUMAN P40763 CHEMBL4026 Signal Transducer And Activator Of Transcription 3, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1