UCSF

Retinoid X Receptor Alpha, Human (344 Compounds)

Swissprot:
RXRA_HUMAN
Stitch:
RXRA_HUMAN
UniProt:
P19793
ChEMBL:
CHEMBL2061
Reactome:
REACT_147904
REACT_111118
REACT_24941
REACT_13812
REACT_11082
REACT_15525
REACT_116145
REACT_11042
REACT_19241
REACT_12528
REACT_118789
REACT_118659
REACT_11054
REACT_11048
REACT_11041
REACT_200608
REACT_27161
REACT_118713
PDB:
1BY4 (DOCK)
1DSZ (DOCK)
1FBY (DOCK)
1FM6 (DOCK)
1FM9 (DOCK)
1G1U (DOCK)
1G5Y (DOCK)
1K74 (DOCK)
1LBD (DOCK)
1MV9 (DOCK)
1MVC (DOCK)
1MZN (DOCK)
1R0N (DOCK)
1RDT (DOCK)
1RXR (DOCK)
1XLS (DOCK)
1XV9 (DOCK)
1XVP (DOCK)
1YNW (DOCK)
2ACL (DOCK)
2NLL (DOCK)
2P1T (DOCK)
2P1U (DOCK)
2P1V (DOCK)
2ZXZ (DOCK)
2ZY0 (DOCK)
3DZU (DOCK)
3DZY (DOCK)
3E00 (DOCK)
3E94 (DOCK)
3FAL (DOCK)
3FC6 (DOCK)
3FUG (DOCK)
3H0A (DOCK)
3KWY (DOCK)
3NSP (DOCK)
3NSQ (DOCK)
3OAP (DOCK)
3OZJ (DOCK)
3PCU (DOCK)
3R29 (DOCK)
3R2A (DOCK)
RXRA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 344 15 7 6
Binding ≤ 1μM 296 10 6 5
Functional ≤ 10μM 225 9 8 6

Reactome Network (18)

Reactome ID Description Species
REACT_147904 Activation of gene expression by SREBF (SREBP) Homo sapiens
REACT_111118 BMAL1:CLOCK,NPAS2 activates circadian gene expression Homo sapiens
REACT_24941 Circadian Clock Homo sapiens
REACT_13812 Endogenous sterols Homo sapiens
REACT_11082 Import of palmitoyl-CoA into the mitochondrial matrix Homo sapiens
REACT_15525 Nuclear Receptor transcription pathway Homo sapiens
REACT_116145 PPARA activates gene expression Homo sapiens
REACT_11042 Recycling of bile acids and salts Homo sapiens
REACT_19241 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp Homo sapiens
REACT_12528 Regulation of pyruvate dehydrogenase (PDH) complex Homo sapiens
REACT_118789 REV-ERBA represses gene expression Homo sapiens
REACT_118659 RORA activates circadian gene expression Homo sapiens
REACT_11054 Synthesis of bile acids and bile salts Homo sapiens
REACT_11048 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Homo sapiens
REACT_11041 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Homo sapiens
REACT_200608 Transcriptional activation of mitochondrial biogenesis Homo sapiens
REACT_27161 Transcriptional regulation of white adipocyte differentiation Homo sapiens
REACT_118713 YAP1- and WWTR1 (TAZ)-stimulated gene expression Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

BMAL1:CLOCK,NPAS2 activates circadian gene expression

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

Circadian Clock

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

Endogenous sterols

Uniprot Swissprot Chembl Description Number Shared
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1

Nuclear Receptor transcription pathway

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 51
RARA_HUMAN P10276 CHEMBL2055 Retinoic Acid Receptor Alpha, Human 61
RARB_HUMAN P10826 CHEMBL2008 Retinoic Acid Receptor Beta, Human 75
RARG_HUMAN P13631 CHEMBL2003 Retinoic Acid Receptor Gamma, Human 78
RXRB_HUMAN P28702 CHEMBL1870 Retinoid X Receptor Beta, Human 127
RXRG_HUMAN P48443 CHEMBL2004 Retinoid X Receptor Gamma, Human 125

PPARA activates gene expression

Uniprot Swissprot Chembl Description Number Shared
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 51

Recycling of bile acids and salts

Uniprot Swissprot Chembl Description Number Shared
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

REV-ERBA represses gene expression

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

RORA activates circadian gene expression

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

Synthesis of bile acids and bile salts

Uniprot Swissprot Chembl Description Number Shared
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1

Transcriptional activation of mitochondrial biogenesis

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2

Transcriptional regulation of white adipocyte differentiation

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 51

YAP1- and WWTR1 (TAZ)-stimulated gene expression

Uniprot Swissprot Chembl Description Number Shared
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
RXRA_MOUSE P28700 CHEMBL3084 Retinoid X Receptor Alpha, Mouse 24 4 3 3
RXRA_RAT Q05343 CHEMBL4431 Retinoid X Receptor Alpha, Rat 19 4 3 3

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
RXRB_HUMAN P28702 CHEMBL1870 Retinoid X Receptor Beta, Human 127
RXRG_HUMAN P48443 CHEMBL2004 Retinoid X Receptor Gamma, Human 125
RARG_HUMAN P13631 CHEMBL2003 Retinoic Acid Receptor Gamma, Human 78
RARB_HUMAN P10826 CHEMBL2008 Retinoic Acid Receptor Beta, Human 75
RXRB_MOUSE P28704 CHEMBL4047 Retinoid X Receptor Beta, Mouse 63
RARA_HUMAN P10276 CHEMBL2055 Retinoic Acid Receptor Alpha, Human 60
RXRG_MOUSE P28705 CHEMBL4402 Retinoid X Receptor Gamma, Mouse 60
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 51
RXRA_MOUSE P28700 CHEMBL3084 Retinoid X Receptor Alpha, Mouse 14
RARA_MOUSE P11416 CHEMBL2792 Retinoic Acid Receptor Alpha, Mouse 13
Z80106 Z80106 CHEMBL614563 COS-1 (Kidney Cells) 12
RARB_MOUSE P22605 CHEMBL3266 Retinoic Acid Receptor Beta, Mouse 11
RARG_MOUSE P18911 CHEMBL4177 Retinoic Acid Receptor Gamma, Mouse 10
RABP1_MOUSE P62965 CHEMBL3208 Cellular Retinoic Acid-binding Protein I, Mouse 6
RABP2_MOUSE P22935 CHEMBL4172 Cellular Retinoic Acid-binding Protein II, Mouse 6
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 6
Z50594 Z50594 CHEMBL375 Mus Musculus 5
RABP1_CHICK P40220 CHEMBL4945 Cellular Retinoic Acid-binding Protein I, Chick 4
RXRA_RAT Q05343 CHEMBL4431 Retinoid X Receptor Alpha, Rat 3
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 2
PPARG_MOUSE P37238 CHEMBL2459 Peroxisome Proliferator-activated Receptor Gamma, Mouse 2
PPARG_RAT O88275 CHEMBL4797 Peroxisome Proliferator-activated Receptor Gamma, Rat 2
RXRB_RAT P49743 CHEMBL2805 Retinoid X Receptor Beta, Rat 2
RXRG_RAT Q5BJR8 CHEMBL4277 Retinoid X Receptor Gamma, Rat 2
Z80006 Z80006 CHEMBL614510 3T3-L1 (Fibroblast Cells) 2
Z80110 Z80110 CHEMBL613507 CV-1 (Kidney Cells) 2
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1
Q499N1_RAT Q499N1 CHEMBL2269 Retinoic Acid Receptor Alpha, Rat 1
Z50518 Z50518 CHEMBL613124 Human Herpesvirus 4 1
Z80135 Z80135 CHEMBL614296 F9 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80377 Z80377 CHEMBL614228 PaCa2 1
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 1
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 1
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 1
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 1

Most Common Rings