UCSF

Serotonin 1b (5-HT1b) Receptor, Rat (452 Compounds)

Swissprot:
5HT1B_RAT
Stitch:
5HT1B_RAT
UniProt:
P28564
ChEMBL:
CHEMBL3459
Reactome:
REACT_233455
REACT_246144
PDB:
Htr1b

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 452 138 55 52
Binding ≤ 1μM 319 93 40 28
Functional ≤ 10μM 1 1 0 0

Reactome Network (2)

Reactome ID Description Species
REACT_233455 G alpha (i) signalling events Rattus norvegicus
REACT_246144 Serotonin receptors Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 264
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 12
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 3
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 36
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 38
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 35
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 107
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 30
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 24
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 4
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 3
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 3
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 5

Serotonin receptors

Uniprot Swissprot Chembl Description Number Shared
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 264
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 232
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 12
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 13
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 23
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 935 52 20 18

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
5HT1B-1-E Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic 1,381 178 69 67
5HT1B-2-E Serotonin 1b (5-HT1b) Receptor (cluster #2 Of 2), Eukaryotic 4 2 0 0
Uniprot Swissprot Chembl Description Number Shared
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 380
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 264
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 244
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 232
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 229
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 218
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 107
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 103
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 83
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 76
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 65
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 60
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 59
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 47
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 47
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 46
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 44
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 39
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 38
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 36
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 36
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 35
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 33
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 30
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 27
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 27
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 27
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 26
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 26
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 25
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 24
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 23
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 23
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 23
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 23
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 23
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 23
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 22
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 20
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 20
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 20
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 18
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 18
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 18
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 18
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 17
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 17
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 17
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 17
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 16
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 15
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 14
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 14
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 13
5HT1D_PIG P79400 CHEMBL4105 Serotonin 1d (5-HT1d) Receptor, Pig 12
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 12
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 12
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 12
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 12
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 12
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 12
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 12
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 11
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 11
ADRB2_CANFA P54833 CHEMBL2289 Beta-2 Adrenergic Receptor, Canine 11
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 11
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 10
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 10
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 10
5HT3B_MOUSE Q9JHJ5 CHEMBL3781 Serotonin 3b (5-HT3b) Receptor, Mouse 9
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 9
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 9
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 8
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 8
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 8
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 7
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 7
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 7
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 6
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 6
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 6
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 6
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 6
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 6
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 5
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 5
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 5
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 5
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 5
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 5
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 5
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 5
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 5
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 5
5HT5A_MOUSE P30966 CHEMBL3597 Serotonin 5a (5-HT5a) Receptor, Mouse 4
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 4
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 4
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 4
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 4
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 4
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 4
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 4
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 3
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 3
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 3
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 3
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 3
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 3
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 3
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 3
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 3
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 3
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 3
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 3
SCN1A_RAT P04774 CHEMBL4906 Sodium Channel Protein Type I Alpha Subunit, Rat 3
SCN2A_RAT P04775 CHEMBL3399 Sodium Channel Protein Type II Alpha Subunit, Rat 3
SCN3A_RAT P08104 CHEMBL4966 Sodium Channel Protein Type III Alpha Subunit, Rat 3
SCN8A_RAT O88420 CHEMBL2752 Sodium Channel Protein Type VIII Alpha Subunit, Rat 3
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 2
5HT3A_CAVPO O70212 CHEMBL3666 Serotonin 3a (5-HT3a) Receptor, Guinea Pig 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACM3_RAT P08483 CHEMBL320 Muscarinic Acetylcholine Receptor M3, Rat 2
ADA2B_BOVIN O77700 CHEMBL3523 Alpha-2b Adrenergic Receptor, Bovin 2
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
DRD2_CHLAE P52702 CHEMBL5456 Dopamine D2 Receptor, Chlae 2
GASR_RAT P30553 CHEMBL3508 Cholecystokinin B Receptor, Rat 2
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
PDR5_YEAST P33302 CHEMBL1697658 Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast 2
PNMT_BOVIN P10938 CHEMBL2331 Phenylethanolamine N-methyltransferase, Bovin 2
5HT2A_PIG P50129 CHEMBL2490 Serotonin 2a (5-HT2a) Receptor, Pig 1
5HT7R_MOUSE P32304 CHEMBL4764 Serotonin 7 (5-HT7) Receptor, Mouse 1
ACM4_RAT P08485 CHEMBL317 Muscarinic Acetylcholine Receptor M4, Rat 1
AP2S1_RAT P62744 CHEMBL1697667 AP-2 Complex Subunit Sigma, Rat 1
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
HRH2_CAVPO P47747 CHEMBL2882 Histamine H2 Receptor, Guinea Pig 1
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 1
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 1