Warning: session_start() [function.session-start]: open(/tmp/session/sess_0emc2e267v2iu1bmsrh2shdp47, O_RDWR) failed: No such file or directory (2) in /domains/zinc12/htdocs/lib/auth/DrupalAuthentication.php on line 251

Warning: session_write_close() [function.session-write-close]: open(/tmp/session/sess_0emc2e267v2iu1bmsrh2shdp47, O_RDWR) failed: No such file or directory (2) in /domains/zinc12/htdocs/lib/zinc/user/ZincAuthentication.php on line 109

Warning: session_write_close() [function.session-write-close]: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/tmp/session) in /domains/zinc12/htdocs/lib/zinc/user/ZincAuthentication.php on line 109
ACES_HUMAN - Acetylcholinesterase, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Acetylcholinesterase, Human (1,893 Compounds)

Swissprot:
ACES_HUMAN
Stitch:
ACES_HUMAN
UniProt:
P22303
ChEMBL:
CHEMBL220
Reactome:
REACT_13583
REACT_121238
REACT_19189
PDB:
1B41 (DOCK)
1F8U (DOCK)
1PUV (DOCK)
1PUW (DOCK)
1VZJ (DOCK)
2CLJ (DOCK)
2X8B (DOCK)
3LII (DOCK)
ACHE

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,893 166 81 42
Binding ≤ 1μM 1,384 124 60 39
Functional ≤ 10μM 63 10 7 7

Reactome Network (3)

Reactome ID Description Species
REACT_13583 Neurotransmitter Clearance In The Synaptic Cleft Homo sapiens
REACT_121238 Synthesis of PC Homo sapiens
REACT_19189 Synthesis, secretion, and deacylation of Ghrelin Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 695

Synthesis of PC

Uniprot Swissprot Chembl Description Number Shared
CHKA_HUMAN P35790 CHEMBL3117 Choline Kinase Alpha, Human 2
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 695

Synthesis, secretion, and deacylation of Ghrelin

Uniprot Swissprot Chembl Description Number Shared
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 695
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACES_BOVIN P23795 CHEMBL4768 Acetylcholinesterase, Bovin 332 18 13 14
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 827 43 30 14
ACES_MOUSE P21836 CHEMBL3198 Acetylcholinesterase, Mouse 174 27 11 14
ACES_RAT P37136 CHEMBL3199 Acetylcholinesterase, Rat 712 37 13 17
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 144 38 13 18

Clustered By Gene (0)

Clustered By Organism (11)

Code Description Substances Purchasable Natural In Man
ACES-1-E Acetylcholinesterase (cluster #1 Of 12), Eukaryotic 1,833 54 43 24
ACES-10-E Acetylcholinesterase (cluster #10 Of 12), Eukaryotic 750 87 33 18
ACES-11-E Acetylcholinesterase (cluster #11 Of 12), Eukaryotic 0 0 0 0
ACES-12-E Acetylcholinesterase (cluster #12 Of 12), Eukaryotic 4 3 2 0
ACES-2-E Acetylcholinesterase (cluster #2 Of 12), Eukaryotic 427 36 9 6
ACES-3-E Acetylcholinesterase (cluster #3 Of 12), Eukaryotic 24 1 4 0
ACES-4-E Acetylcholinesterase (cluster #4 Of 12), Eukaryotic 9 3 5 1
ACES-5-E Acetylcholinesterase (cluster #5 Of 12), Eukaryotic 336 29 9 8
ACES-6-E Acetylcholinesterase (cluster #6 Of 12), Eukaryotic 62 1 1 1
ACES-7-E Acetylcholinesterase (cluster #7 Of 12), Eukaryotic 1 1 0 0
ACES-8-E Acetylcholinesterase (cluster #8 Of 12), Eukaryotic 36 5 3 1
ACES-9-E Acetylcholinesterase (cluster #9 Of 12), Eukaryotic 18 10 3 4
Uniprot Swissprot Chembl Description Number Shared
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 695
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 187
ACES_RAT P37136 CHEMBL3199 Acetylcholinesterase, Rat 166
ACES_BOVIN P23795 CHEMBL4768 Acetylcholinesterase, Bovin 155
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 74
ACES_MOUSE P21836 CHEMBL3198 Acetylcholinesterase, Mouse 71
Q9JKC1_RAT Q9JKC1 CHEMBL3403 Butyrylcholinesterase, Rat 40
CHLE_HORSE P81908 CHEMBL5763 Cholinesterase, Horse 34
ACM1_MOUSE P12657 CHEMBL3733 Muscarinic Acetylcholine Receptor M1, Mouse 31
Q9N1N9_HORSE Q9N1N9 CHEMBL5077 Butyrylcholinesterase, Horse 29
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 21
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 18
LIPS_RAT P15304 CHEMBL5582 Hormone-sensitive Lipase, Rat 18
ACM2_MOUSE Q9ERZ4 CHEMBL3197 Muscarinic Acetylcholine Receptor M2, Mouse 17
LIPS_HUMAN Q05469 CHEMBL3590 Hormone Sensitive Lipase, Human 17
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 13
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 12
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 11
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 11
ACHA7_RAT Q05941 CHEMBL4980 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat 8
ACM2_PIG P06199 CHEMBL4781 Muscarinic Acetylcholine Receptor M2, Pig 7
CHLE_MOUSE Q03311 CHEMBL2528 Butyrylcholinesterase, Mouse 6
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 6
EST1_HUMAN P23141 CHEMBL2265 Acyl Coenzyme A:cholesterol Acyltransferase, Human 6
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 6
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 5
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 5
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 4
CLAT_RAT P32738 CHEMBL3945 Choline Acetylase, Rat 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 4
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 3
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 3
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 3
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 3
AGTRB_RAT P29089 CHEMBL263 Angiotensin II Type 1b (AT-1b) Receptor, Rat 3
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 3
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 3
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 3
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 2
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 2
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 2
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
CHKA_HUMAN P35790 CHEMBL3117 Choline Kinase Alpha, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
EST1_RABIT P12337 CHEMBL2623 Acyl Coenzyme A:cholesterol Acyltransferase, Rabit 2
EST2_HUMAN O00748 CHEMBL3180 Carboxylesterase 2, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HNMT_RAT Q01984 CHEMBL3241 Histamine N-methyltransferase, Rat 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 2
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 2
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 2
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 2
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 2
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 2
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 2
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 2
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 1
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 1
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 1
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 1
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 1
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 1
ACHE_HUMAN Q04844 CHEMBL2484 Acetylcholine Receptor Protein Epsilon Chain, Human 1
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EST1_PIG Q29550 CHEMBL3383 Carboxylesterase, Pig 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
I23O1_HUMAN P14902 CHEMBL4685 Indoleamine 2,3-dioxygenase, Human 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PPGB_HUMAN P10619 CHEMBL6115 Lysosomal Protective Protein, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 1
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 1
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 1
Z104298 Z104298 CHEMBL1907604 Glutamate NMDA Receptor; GRIN1/GRIN2A 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1

Most Common Rings