ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (1,893)
Reactome (3)
Related By:
Pathway (3)
Organism (5)
Gene (0)
Org. Clust. (11)
ChEMBL (121)
Rings (50)

Acetylcholinesterase, Human (1,893 Compounds)

Swissprot:: ACES_HUMAN
Stitch:: ACES_HUMAN
UniProt:: P22303
ChEMBL:: CHEMBL220
Reactome:: REACT_13583; REACT_121238; REACT_19189
PDB:: 1B41 (DOCK); 1F8U (DOCK); 1PUV (DOCK); 1PUW (DOCK); 1VZJ (DOCK); 2CLJ (DOCK); 2X8B (DOCK); 3LII (DOCK); ACHE

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,893	166	81	42
Binding ≤ 1μM	1,384	124	60	39
Functional ≤ 10μM	63	10	7	7

Reactome ID	Description	Species
REACT_13583	Neurotransmitter Clearance In The Synaptic Cleft	Homo sapiens
REACT_121238	Synthesis of PC	Homo sapiens
REACT_19189	Synthesis, secretion, and deacylation of Ghrelin	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	695

Synthesis of PC

Uniprot	Swissprot	Chembl	Description	Number Shared
CHKA_HUMAN	P35790	CHEMBL3117	Choline Kinase Alpha, Human	2
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	695

Synthesis, secretion, and deacylation of Ghrelin

Uniprot	Swissprot	Chembl	Description	Number Shared
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	695

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ACES_BOVIN	P23795	CHEMBL4768	Acetylcholinesterase, Bovin	332	18	13	14
ACES_ELEEL	O42275	CHEMBL4078	Acetylcholinesterase, Eleel	827	43	30	14
ACES_MOUSE	P21836	CHEMBL3198	Acetylcholinesterase, Mouse	174	27	11	14
ACES_RAT	P37136	CHEMBL3199	Acetylcholinesterase, Rat	712	37	13	17
ACES_TORCA	P04058	CHEMBL4780	Acetylcholinesterase, Torca	144	38	13	18

Clustered By Gene (0)

Clustered By Organism (11)

Code	Description	Substances	Purchasable	Natural	In Man
ACES-1-E	Acetylcholinesterase (cluster #1 Of 12), Eukaryotic	1,833	54	43	24
ACES-10-E	Acetylcholinesterase (cluster #10 Of 12), Eukaryotic	750	87	33	18
ACES-11-E	Acetylcholinesterase (cluster #11 Of 12), Eukaryotic	0	0	0	0
ACES-12-E	Acetylcholinesterase (cluster #12 Of 12), Eukaryotic	4	3	2	0
ACES-2-E	Acetylcholinesterase (cluster #2 Of 12), Eukaryotic	427	36	9	6
ACES-3-E	Acetylcholinesterase (cluster #3 Of 12), Eukaryotic	24	1	4	0
ACES-4-E	Acetylcholinesterase (cluster #4 Of 12), Eukaryotic	9	3	5	1
ACES-5-E	Acetylcholinesterase (cluster #5 Of 12), Eukaryotic	336	29	9	8
ACES-6-E	Acetylcholinesterase (cluster #6 Of 12), Eukaryotic	62	1	1	1
ACES-7-E	Acetylcholinesterase (cluster #7 Of 12), Eukaryotic	1	1	0	0
ACES-8-E	Acetylcholinesterase (cluster #8 Of 12), Eukaryotic	36	5	3	1
ACES-9-E	Acetylcholinesterase (cluster #9 Of 12), Eukaryotic	18	10	3	4

Uniprot	Swissprot	Chembl	Description	Number Shared
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	695
ACES_ELEEL	O42275	CHEMBL4078	Acetylcholinesterase, Eleel	187
ACES_RAT	P37136	CHEMBL3199	Acetylcholinesterase, Rat	166
ACES_BOVIN	P23795	CHEMBL4768	Acetylcholinesterase, Bovin	155
ACES_TORCA	P04058	CHEMBL4780	Acetylcholinesterase, Torca	74
ACES_MOUSE	P21836	CHEMBL3198	Acetylcholinesterase, Mouse	71
Q9JKC1_RAT	Q9JKC1	CHEMBL3403	Butyrylcholinesterase, Rat	40
CHLE_HORSE	P81908	CHEMBL5763	Cholinesterase, Horse	34
ACM1_MOUSE	P12657	CHEMBL3733	Muscarinic Acetylcholine Receptor M1, Mouse	31
Q9N1N9_HORSE	Q9N1N9	CHEMBL5077	Butyrylcholinesterase, Horse	29
AOFA_RAT	P21396	CHEMBL3358	Monoamine Oxidase A, Rat	21
ACM2_RAT	P10980	CHEMBL309	Muscarinic Acetylcholine Receptor M2, Rat	18
LIPS_RAT	P15304	CHEMBL5582	Hormone-sensitive Lipase, Rat	18
ACM2_MOUSE	Q9ERZ4	CHEMBL3197	Muscarinic Acetylcholine Receptor M2, Mouse	17
LIPS_HUMAN	Q05469	CHEMBL3590	Hormone Sensitive Lipase, Human	17
BACE1_HUMAN	P56817	CHEMBL4822	Beta-secretase 1, Human	13
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	12
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	11
AOFB_RAT	P19643	CHEMBL2993	Monoamine Oxidase B, Rat	11
ACHA7_RAT	Q05941	CHEMBL4980	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat	8
ACM2_PIG	P06199	CHEMBL4781	Muscarinic Acetylcholine Receptor M2, Pig	7
CHLE_MOUSE	Q03311	CHEMBL2528	Butyrylcholinesterase, Mouse	6
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	6
EST1_HUMAN	P23141	CHEMBL2265	Acyl Coenzyme A:cholesterol Acyltransferase, Human	6
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	6
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	5
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	5
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	4
CLAT_RAT	P32738	CHEMBL3945	Choline Acetylase, Rat	4
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	4
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	4
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	3
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	3
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	3
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	3
AGTRB_RAT	P29089	CHEMBL263	Angiotensin II Type 1b (AT-1b) Receptor, Rat	3
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine Oxidase B, Human	3
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	3
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	3
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	3
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	2
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	2
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	2
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	2
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	2
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	2
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	2
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
CHKA_HUMAN	P35790	CHEMBL3117	Choline Kinase Alpha, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
EST1_RABIT	P12337	CHEMBL2623	Acyl Coenzyme A:cholesterol Acyltransferase, Rabit	2
EST2_HUMAN	O00748	CHEMBL3180	Carboxylesterase 2, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HNMT_RAT	Q01984	CHEMBL3241	Histamine N-methyltransferase, Rat	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2
PTPRC_HUMAN	P08575	CHEMBL3243	Leukocyte Common Antigen, Human	2
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	2
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SC6A2_MOUSE	O55192	CHEMBL2370	Norepinephrine Transporter, Mouse	2
SC6A3_MOUSE	Q61327	CHEMBL2799	Dopamine Transporter, Mouse	2
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	2
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	2
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	2
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	1
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	1
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	1
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	1
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) Receptor, Rat	1
5HT4R_RAT	Q62758	CHEMBL4317	Serotonin 4 (5-HT4) Receptor, Rat	1
ACHE_HUMAN	Q04844	CHEMBL2484	Acetylcholine Receptor Protein Epsilon Chain, Human	1
CASP1_HUMAN	P29466	CHEMBL4801	Caspase-1, Human	1
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	1
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	1
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	1
EST1_PIG	Q29550	CHEMBL3383	Carboxylesterase, Pig	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1
I23O1_HUMAN	P14902	CHEMBL4685	Indoleamine 2,3-dioxygenase, Human	1
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	1
PGH2_HUMAN	P35354	CHEMBL230	Cyclooxygenase-2, Human	1
PPGB_HUMAN	P10619	CHEMBL6115	Lysosomal Protective Protein, Human	1
PTN1_HUMAN	P18031	CHEMBL335	Protein-tyrosine Phosphatase 1B, Human	1
Q4U254_9ENTO	Q4U254	CHEMBL2857	Human Rhinovirus A Protease, 9ento	1
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	1
Z100491	Z100491	CHEMBL613288	Sigma 2 Receptor	1
Z104288	Z104288	CHEMBL1907594	Neuronal Acetylcholine Receptor; Alpha3/beta4	1
Z104298	Z104298	CHEMBL1907604	Glutamate NMDA Receptor; GRIN1/GRIN2A	1
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	1
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1