UCSF

Acetylcholinesterase, Mouse (174 Compounds)

Swissprot:
ACES_MOUSE
Stitch:
ACES_MOUSE
UniProt:
P21836
ChEMBL:
CHEMBL3198
Reactome:
REACT_251127
REACT_207335
PDB:
1C2B (DOCK)
1C2O (DOCK)
1J06 (DOCK)
1J07 (DOCK)
1KU6 (DOCK)
1MAA (DOCK)
1MAH (DOCK)
1N5M (DOCK)
1N5R (DOCK)
1Q83 (DOCK)
1Q84 (DOCK)
2C0P (DOCK)
2C0Q (DOCK)
2GYU (DOCK)
2GYV (DOCK)
2GYW (DOCK)
2H9Y (DOCK)
2HA0 (DOCK)
2HA2 (DOCK)
2HA3 (DOCK)
2HA4 (DOCK)
2HA5 (DOCK)
2HA6 (DOCK)
2HA7 (DOCK)
2JEY (DOCK)
2JEZ (DOCK)
2JF0 (DOCK)
2JGE (DOCK)
2JGF (DOCK)
2JGG (DOCK)
2JGH (DOCK)
2JGI (DOCK)
2JGJ (DOCK)
2JGK (DOCK)
2JGL (DOCK)
2JGM (DOCK)
2WHP (DOCK)
2WHQ (DOCK)
2WHR (DOCK)
2WLS (DOCK)
2WU3 (DOCK)
2WU4 (DOCK)
2XUD (DOCK)
2XUF (DOCK)
2XUG (DOCK)
2XUH (DOCK)
2XUI (DOCK)
2XUJ (DOCK)
2XUK (DOCK)
2XUO (DOCK)
2XUP (DOCK)
2XUQ (DOCK)
2Y2U (DOCK)
2Y2V (DOCK)
3DL4 (DOCK)
3DL7 (DOCK)
4A23 (DOCK)
Ache

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 174 27 11 14
Binding ≤ 1μM 140 15 9 11
Functional ≤ 10μM 7 1 0 1

Reactome Network (2)

Reactome ID Description Species
REACT_251127 Neurotransmitter Clearance In The Synaptic Cleft Mus musculus
REACT_207335 Synthesis of PC Mus musculus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACES_BOVIN P23795 CHEMBL4768 Acetylcholinesterase, Bovin 332 18 13 14
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 827 43 30 14
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 1,893 166 81 42
ACES_RAT P37136 CHEMBL3199 Acetylcholinesterase, Rat 712 37 13 17
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 144 38 13 18

Clustered By Gene (0)

Clustered By Organism (11)

Code Description Substances Purchasable Natural In Man
ACES-1-E Acetylcholinesterase (cluster #1 Of 12), Eukaryotic 1,833 54 43 24
ACES-10-E Acetylcholinesterase (cluster #10 Of 12), Eukaryotic 750 87 33 18
ACES-11-E Acetylcholinesterase (cluster #11 Of 12), Eukaryotic 0 0 0 0
ACES-12-E Acetylcholinesterase (cluster #12 Of 12), Eukaryotic 4 3 2 0
ACES-2-E Acetylcholinesterase (cluster #2 Of 12), Eukaryotic 427 36 9 6
ACES-3-E Acetylcholinesterase (cluster #3 Of 12), Eukaryotic 24 1 4 0
ACES-4-E Acetylcholinesterase (cluster #4 Of 12), Eukaryotic 9 3 5 1
ACES-5-E Acetylcholinesterase (cluster #5 Of 12), Eukaryotic 336 29 9 8
ACES-6-E Acetylcholinesterase (cluster #6 Of 12), Eukaryotic 62 1 1 1
ACES-7-E Acetylcholinesterase (cluster #7 Of 12), Eukaryotic 1 1 0 0
ACES-8-E Acetylcholinesterase (cluster #8 Of 12), Eukaryotic 36 5 3 1
ACES-9-E Acetylcholinesterase (cluster #9 Of 12), Eukaryotic 18 10 3 4
Uniprot Swissprot Chembl Description Number Shared
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 71
CHLE_MOUSE Q03311 CHEMBL2528 Butyrylcholinesterase, Mouse 23
ACES_RAT P37136 CHEMBL3199 Acetylcholinesterase, Rat 17
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 9
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 9
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 7
FAAH1_MOUSE O08914 CHEMBL3455 Anandamide Amidohydrolase, Mouse 6
MGLL_MOUSE O35678 CHEMBL5774 Monoglyceride Lipase, Mouse 6
ACES_BOVIN P23795 CHEMBL4768 Acetylcholinesterase, Bovin 5
CHLE_HORSE P81908 CHEMBL5763 Cholinesterase, Horse 5
Q9JKC1_RAT Q9JKC1 CHEMBL3403 Butyrylcholinesterase, Rat 5
CNR1_MOUSE P47746 CHEMBL3037 Cannabinoid CB1 Receptor, Mouse 4
ACM1_MOUSE P12657 CHEMBL3733 Muscarinic Acetylcholine Receptor M1, Mouse 3
ACM2_MOUSE Q9ERZ4 CHEMBL3197 Muscarinic Acetylcholine Receptor M2, Mouse 3
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 3
CLAT_RAT P32738 CHEMBL3945 Choline Acetylase, Rat 3
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 3
Q9N1N9_HORSE Q9N1N9 CHEMBL5077 Butyrylcholinesterase, Horse 3
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 3
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM4_RAT P08485 CHEMBL317 Muscarinic Acetylcholine Receptor M4, Rat 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
CNR1_RAT P20272 CHEMBL3571 Cannabinoid CB1 Receptor, Rat 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
ACHA2_RAT P12389 CHEMBL2584 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat 1
ACHB2_RAT P12390 CHEMBL3001 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat 1
ACHB4_RAT P12392 CHEMBL2658 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat 1
ACHD_TORCA P02718 CHEMBL3916 Acetylcholine Receptor Protein Delta Chain, Torca 1
ACHE_HUMAN Q04844 CHEMBL2484 Acetylcholine Receptor Protein Epsilon Chain, Human 1
ACM2_PIG P06199 CHEMBL4781 Muscarinic Acetylcholine Receptor M2, Pig 1
ACM3_RAT P08483 CHEMBL320 Muscarinic Acetylcholine Receptor M3, Rat 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
HNMT_RAT Q01984 CHEMBL3241 Histamine N-methyltransferase, Rat 1
Z104281 Z104281 CHEMBL1907587 Neuronal Acetylcholine Receptor; Alpha3/beta2 1
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 1
Z104286 Z104286 CHEMBL1907592 Neuronal Acetylcholine Receptor; Alpha2/beta2 1
Z104287 Z104287 CHEMBL1907593 Neuronal Acetylcholine Receptor; Alpha3/beta4 1
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 1
Z104289 Z104289 CHEMBL1907595 Neuronal Acetylcholine Receptor; Alpha4/beta4 1
Z104290 Z104290 CHEMBL1907596 Neuronal Acetylcholine Receptor; Alpha4/beta2 1
Z104298 Z104298 CHEMBL1907604 Glutamate NMDA Receptor; GRIN1/GRIN2A 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1