ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (1,168)
Reactome (1)
Related By:
Pathway (5)
Organism (3)
Gene (2)
Org. Clust. (0)
ChEMBL (30)
Rings (6)

Angiotensin-converting Enzyme, Human (1,168 Compounds)

Swissprot:: ACE_HUMAN
Stitch:: ACE_HUMAN
UniProt:: P12821
ChEMBL:: CHEMBL1808
Reactome:: REACT_147707
PDB:: 1O86 (DOCK); 1O8A (DOCK); 1UZE (DOCK); 1UZF (DOCK); 2C6F (DOCK); 2C6N (DOCK); 2IUL (DOCK); 2IUX (DOCK); 2OC2 (DOCK); 2XY9 (DOCK); 2XYD (DOCK); 2YDM (DOCK); 3BKK (DOCK); 3BKL (DOCK); 3L3N (DOCK); 3NXQ (DOCK); ACE

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,168	112	39	37
Binding ≤ 1μM	957	93	34	32

Reactome ID	Description	Species
REACT_147707	Metabolism of Angiotensinogen to Angiotensins	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ACE2_HUMAN	Q9BYF1	CHEMBL3736	Angiotensin-converting Enzyme 2, Human	164
AMPE_HUMAN	Q07075	CHEMBL3439	Aminopeptidase A, Human	2
AMPN_HUMAN	P15144	CHEMBL1907	Aminopeptidase N, Human	2
NEP_HUMAN	P08473	CHEMBL1944	Neprilysin, Human	202
RENI_HUMAN	P00797	CHEMBL286	Renin, Human	4

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ACE_MOUSE	P09470	CHEMBL2994	Angiotensin-converting Enzyme, Mouse	98	2	0	0
ACE_RABIT	P12822	CHEMBL4074	Angiotensin-converting Enzyme, Rabit	114	9	4	3
ACE_RAT	P47820	CHEMBL2625	Angiotensin-converting Enzyme, Rat	505	40	13	19

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ACE2_HUMAN	Q9BYF1	CHEMBL3736	Angiotensin-converting Enzyme 2, Human	205	16	5	5
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	1,893	166	81	42

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
NEP_HUMAN	P08473	CHEMBL1944	Neprilysin, Human	202
ACE2_HUMAN	Q9BYF1	CHEMBL3736	Angiotensin-converting Enzyme 2, Human	164
NEP_RAT	P07861	CHEMBL3369	Neprilysin, Rat	77
ACE_RAT	P47820	CHEMBL2625	Angiotensin-converting Enzyme, Rat	50
LKHA4_CAVPO	P19602	CHEMBL5786	Leukotriene A-4 Hydrolase, Guinea Pig	50
NEP_PIG	P19621	CHEMBL6107	Neprilysin, Pig	34
ECE1_HUMAN	P42892	CHEMBL4791	Endothelin-converting Enzyme 1, Human	27
THER_BACTH	P00800	CHEMBL3392	Thermolysin, Bacth	12
THAS_HUMAN	P24557	CHEMBL1835	Thromboxane-A Synthase, Human	10
ACE_RABIT	P12822	CHEMBL4074	Angiotensin-converting Enzyme, Rabit	8
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	5
ECE1_RAT	P42893	CHEMBL2676	Endothelin-converting Enzyme 1, Rat	4
RENI_HUMAN	P00797	CHEMBL286	Renin, Human	4
ACE2_RAT	Q5EGZ1	CHEMBL2311	Angiotensin-converting Enzyme-related Carboxypeptidase, Rat	2
AMPB_HUMAN	Q9H4A4	CHEMBL2432	Aminopeptidase B, Human	2
AMPE_HUMAN	Q07075	CHEMBL3439	Aminopeptidase A, Human	2
AMPN_HUMAN	P15144	CHEMBL1907	Aminopeptidase N, Human	2
LKHA4_HUMAN	P09960	CHEMBL4618	Leukotriene A4 Hydrolase, Human	2
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	2
AGTR1_BOVIN	P25104	CHEMBL3374	Angiotensin II Type 1a (AT-1a) Receptor, Bovin	1
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	1
AGTR2_HUMAN	P50052	CHEMBL4607	Angiotensin II Type 2 (AT-2) Receptor, Human	1
AGTR2_RAT	P35351	CHEMBL257	Angiotensin II Type 2 (AT-2) Receptor, Rat	1
AGTRA_RAT	P25095	CHEMBL329	Angiotensin II Type 1a (AT-1a) Receptor, Rat	1
AGTRB_RAT	P29089	CHEMBL263	Angiotensin II Type 1b (AT-1b) Receptor, Rat	1
ANF_HUMAN	P01160	CHEMBL1293193	Atrial Natriuretic Factor, Human	1
CXCR4_HUMAN	P61073	CHEMBL2107	C-X-C Chemokine Receptor Type 4, Human	1
DAPE_HAEIN	P44514	CHEMBL1075192	Succinyl-diaminopimelate Desuccinylase, Haein	1
ENV_HV1H2	P04578	CHEMBL3520	Envelope Polyprotein GP160, Hv1h2	1
THRB_HUMAN	P00734	CHEMBL204	Thrombin, Human	1