ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (1,592)
Reactome (12)
Related By:
Pathway (17)
Organism (3)
Gene (12)
Org. Clust. (1)
ChEMBL (45)
Rings (26)

ADAM17, Human (1,592 Compounds)

Swissprot:: ADA17_HUMAN
Stitch:: ADA17_HUMAN
UniProt:: P78536
ChEMBL:: CHEMBL3706
Reactome:: REACT_118614; REACT_150401; REACT_160089; REACT_160254; REACT_160243; REACT_160106; REACT_111133; REACT_116022; REACT_13443; REACT_228239; REACT_9417; REACT_1432
PDB:: 1BKC (DOCK); 1ZXC (DOCK); 2A8H (DOCK); 2DDF (DOCK); 2FV5 (DOCK); 2FV9 (DOCK); 2I47 (DOCK); 2OI0 (DOCK); 3B92 (DOCK); 3CKI (DOCK); 3E8R (DOCK); 3EDZ (DOCK); 3EWJ (DOCK); 3G42 (DOCK); 3KMC (DOCK); 3KME (DOCK); 3L0T (DOCK); 3L0V (DOCK); 3LE9 (DOCK); 3LEA (DOCK); 3LGP (DOCK); 3O64 (DOCK); ADAM17

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,592	7	5	20
Binding ≤ 1μM	1,472	4	5	18
Functional ≤ 10μM	315	2	2	4

Reactome ID	Description	Species
REACT_118614	Activated NOTCH1 Transmits Signal to the Nucleus	Homo sapiens
REACT_150401	Collagen degradation	Homo sapiens
REACT_160089	Constitutive Signaling by NOTCH1 HD Domain Mutants	Homo sapiens
REACT_160254	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Homo sapiens
REACT_160243	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Homo sapiens
REACT_160106	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	Homo sapiens
REACT_111133	Growth hormone receptor signaling	Homo sapiens
REACT_116022	Nuclear signaling by ERBB4	Homo sapiens
REACT_13443	Regulated proteolysis of p75NTR	Homo sapiens
REACT_228239	Release of Hh-Np from the secreting cell	Homo sapiens
REACT_9417	Signaling by EGFR	Homo sapiens
REACT_1432	TNF signaling	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21

Collagen degradation

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	59
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	4
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	1
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	13
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	605
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	106
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	4
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	583
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	268
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	245
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	24
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	32
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	457

Constitutive Signaling by NOTCH1 HD Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21

Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21

Signaling by EGFR

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21
ADA12_HUMAN	O43184	CHEMBL5030	ADAM12, Human	1

TNF signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
TNFA_HUMAN	P01375	CHEMBL1825	TNF-alpha, Human	31

UniProt	Swissprot	ChEMBL	Description	Substances	In Man
ADA17_MOUSE	Q9Z0F8	CHEMBL4379	ADAM17, Mouse	1	1
ADA17_PIG	O77636	CHEMBL3332	ADAM17, Pig	418	1
ADA17_RAT	Q9Z1K9	CHEMBL2523	ADAM17, Rat	7	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	168	1	1	2
ADA12_HUMAN	O43184	CHEMBL5030	ADAM12, Human	8	8	1	1
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	1,217	94	55	50
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	1,203	86	55	50
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	1,085	77	49	46
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	690	104	52	54
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	422	76	40	40
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	620	92	51	50
ADA33_HUMAN	Q9BZ11	CHEMBL6121	Disintegrin And Metalloproteinase Domain-containing Protein 33, Human	3	0	0	1
ADAM8_HUMAN	P78325	CHEMBL5665	Disintegrin And Metalloproteinase Domain-containing Protein 8, Human	1	0	0	0
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	66	1	1	1
ADA_HUMAN	P00813	CHEMBL1910	Adenosine Deaminase, Human	57	6	3	12

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
ADA17-1-E	ADAM17 (cluster #1 Of 2), Eukaryotic	1,066	3	3	8
ADA17-2-E	ADAM17 (cluster #2 Of 2), Eukaryotic	911	4	2	14

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	572
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	560
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	434
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	250
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	227
Z50587	Z50587	CHEMBL372	Homo Sapiens	108
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	104
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	59
ADA17_PIG	O77636	CHEMBL3332	ADAM17, Pig	53
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	29
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	29
TNFA_HUMAN	P01375	CHEMBL1825	TNF-alpha, Human	28
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	23
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	21
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	19
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	13
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	11
ATS5_BOVIN	Q9TT92	CHEMBL2673	ADAMTS5, Bovin	10
AREG_HUMAN	P15514	CHEMBL3731	Amphiregulin, Human	5
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	5
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	4
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	4
Z100081	Z100081	CHEMBL613107	PBMC (Peripheral Blood Mononuclear Cells)	4
ADA33_HUMAN	Q9BZ11	CHEMBL6121	Disintegrin And Metalloproteinase Domain-containing Protein 33, Human	3
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	3
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	3
Z80548	Z80548	CHEMBL614245	THP-1 (Acute Monocytic Leukemia Cells)	3
FCER2_HUMAN	P06734	CHEMBL2940	Immunoglobulin Epsilon Fc Receptor, Human	2
LEF_BACAN	P15917	CHEMBL4372	Anthrax Lethal Factor, Bacan	2
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	2
ADA12_HUMAN	O43184	CHEMBL5030	ADAM12, Human	1
ADA17_MOUSE	Q9Z0F8	CHEMBL4379	ADAM17, Mouse	1
ADAM8_HUMAN	P78325	CHEMBL5665	Disintegrin And Metalloproteinase Domain-containing Protein 8, Human	1
ATS4_BOVIN	Q9TT93	CHEMBL3874	ADAMTS4, Bovin	1
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	1
CAH4_BOVIN	Q95323	CHEMBL281	Carbonic Anhydrase IV, Bovin	1
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	1
MMP12_MOUSE	P34960	CHEMBL2594	Matrix Metalloproteinase 12, Mouse	1
MMP13_RAT	P23097	CHEMBL4944	Matrix Metalloproteinase 13, Rat	1
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	1
MMP2_MOUSE	P33434	CHEMBL3095	Matrix Metalloproteinase-2, Mouse	1
MMP9_MOUSE	P41245	CHEMBL2214	Matrix Metalloproteinase 9, Mouse	1
NEP_HUMAN	P08473	CHEMBL1944	Neprilysin, Human	1
Z50591	Z50591	CHEMBL613489	Bos Taurus	1