UCSF

ADAM17, Human (1,592 Compounds)

Swissprot:
ADA17_HUMAN
Stitch:
ADA17_HUMAN
UniProt:
P78536
ChEMBL:
CHEMBL3706
Reactome:
REACT_118614
REACT_150401
REACT_160089
REACT_160254
REACT_160243
REACT_160106
REACT_111133
REACT_116022
REACT_13443
REACT_228239
REACT_9417
REACT_1432
PDB:
1BKC (DOCK)
1ZXC (DOCK)
2A8H (DOCK)
2DDF (DOCK)
2FV5 (DOCK)
2FV9 (DOCK)
2I47 (DOCK)
2OI0 (DOCK)
3B92 (DOCK)
3CKI (DOCK)
3E8R (DOCK)
3EDZ (DOCK)
3EWJ (DOCK)
3G42 (DOCK)
3KMC (DOCK)
3KME (DOCK)
3L0T (DOCK)
3L0V (DOCK)
3LE9 (DOCK)
3LEA (DOCK)
3LGP (DOCK)
3O64 (DOCK)
ADAM17

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,592 7 5 20
Binding ≤ 1μM 1,472 4 5 18
Functional ≤ 10μM 315 2 2 4
Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 59
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 4
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 13
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 605
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 106
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 4
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 583
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 268
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 245
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 24
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 32
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 457

Constitutive Signaling by NOTCH1 HD Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21

Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21

Signaling by EGFR

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1

TNF signaling

Uniprot Swissprot Chembl Description Number Shared
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 31
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADA17_MOUSE Q9Z0F8 CHEMBL4379 ADAM17, Mouse 1 0 0 1
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 418 0 0 1
ADA17_RAT Q9Z1K9 CHEMBL2523 ADAM17, Rat 7 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 168 1 1 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 8 8 1 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1,217 94 55 50
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 1,203 86 55 50
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 1,085 77 49 46
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 690 104 52 54
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 422 76 40 40
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 620 92 51 50
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 3 0 0 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1 0 0 0
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 66 1 1 1
ADA_HUMAN P00813 CHEMBL1910 Adenosine Deaminase, Human 57 6 3 12

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADA17-1-E ADAM17 (cluster #1 Of 2), Eukaryotic 1,066 3 3 8
ADA17-2-E ADAM17 (cluster #2 Of 2), Eukaryotic 911 4 2 14
Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 572
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 560
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 434
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 250
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 227
Z50587 Z50587 CHEMBL372 Homo Sapiens 108
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 104
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 59
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 53
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 29
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 28
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 23
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 21
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 19
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 13
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 11
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 10
AREG_HUMAN P15514 CHEMBL3731 Amphiregulin, Human 5
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 5
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 4
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 4
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 4
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 3
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 3
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 3
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 3
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 2
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 2
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA17_MOUSE Q9Z0F8 CHEMBL4379 ADAM17, Mouse 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS4_BOVIN Q9TT93 CHEMBL3874 ADAMTS4, Bovin 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 1
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 1
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 1
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 1
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 1
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 1
Z50591 Z50591 CHEMBL613489 Bos Taurus 1