Annotation Type | Substances | Purchasable | Natural | In Man |
---|---|---|---|---|
Binding ≤ 10μM | 46 | 3 | 1 | 0 |
Binding ≤ 1μM | 37 | 2 | 0 | 0 |
Functional ≤ 10μM | 1 | 1 | 0 | 0 |
Reactome ID | Description | Species |
---|---|---|
REACT_15312 | Adenylate cyclase activating pathway | Homo sapiens |
REACT_15333 | Adenylate cyclase inhibitory pathway | Homo sapiens |
REACT_18339 | Adrenaline,noradrenaline inhibits insulin secretion | Homo sapiens |
REACT_19231 | G alpha (i) signalling events | Homo sapiens |
REACT_19327 | G alpha (s) signalling events | Homo sapiens |
REACT_19333 | G alpha (z) signalling events | Homo sapiens |
REACT_1665 | Glucagon signaling in metabolic regulation | Homo sapiens |
REACT_18274 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Homo sapiens |
REACT_15530 | PKA activation | Homo sapiens |
REACT_1946 | PKA activation in glucagon signalling | Homo sapiens |
REACT_24023 | Vasopressin regulates renal water homeostasis via Aquaporins | Homo sapiens |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADA2A_HUMAN | P08913 | CHEMBL1867 | Alpha-2a Adrenergic Receptor, Human | 3 |
ADA2C_HUMAN | P18825 | CHEMBL1916 | Alpha-2c Adrenergic Receptor, Human | 2 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
AA1R_HUMAN | P30542 | CHEMBL226 | Adenosine A1 Receptor, Human | 1 |
AA3R_HUMAN | P33765 | CHEMBL256 | Adenosine A3 Receptor, Human | 1 |
ADA2A_HUMAN | P08913 | CHEMBL1867 | Alpha-2a Adrenergic Receptor, Human | 3 |
ADA2B_HUMAN | P18089 | CHEMBL1942 | Alpha-2b Adrenergic Receptor, Human | 2 |
ADA2C_HUMAN | P18825 | CHEMBL1916 | Alpha-2c Adrenergic Receptor, Human | 2 |
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
DRD2_HUMAN | P14416 | CHEMBL217 | Dopamine D2 Receptor, Human | 2 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
5HT6R_HUMAN | P50406 | CHEMBL3371 | Serotonin 6 (5-HT6) Receptor, Human | 1 |
AA2AR_HUMAN | P29274 | CHEMBL251 | Adenosine A2a Receptor, Human | 1 |
AA2BR_HUMAN | P29275 | CHEMBL255 | Adenosine A2b Receptor, Human | 1 |
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
DRD1_HUMAN | P21728 | CHEMBL2056 | Dopamine D1 Receptor, Human | 2 |
DRD5_HUMAN | P21918 | CHEMBL1850 | Dopamine D5 Receptor, Human | 2 |
GIPR_HUMAN | P48546 | CHEMBL4383 | Gastric Inhibitory Polypeptide Receptor, Human | 1 |
GLP1R_HUMAN | P43220 | CHEMBL1784 | Glucagon-like Peptide Receptor, Human | 1 |
GLR_HUMAN | P47871 | CHEMBL1985 | Glucagon Receptor, Human | 23 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADA2A_HUMAN | P08913 | CHEMBL1867 | Alpha-2a Adrenergic Receptor, Human | 3 |
ADA2B_HUMAN | P18089 | CHEMBL1942 | Alpha-2b Adrenergic Receptor, Human | 2 |
ADA2C_HUMAN | P18825 | CHEMBL1916 | Alpha-2c Adrenergic Receptor, Human | 2 |
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
GLR_HUMAN | P47871 | CHEMBL1985 | Glucagon Receptor, Human | 23 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
GLP1R_HUMAN | P43220 | CHEMBL1784 | Glucagon-like Peptide Receptor, Human | 1 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
---|---|---|---|---|---|---|---|
ADCY5_MOUSE | P84309 | CHEMBL2561 | Adenylate Cyclase Type V, Mouse | 2 | 0 | 0 | 0 |
ADCY5_RAT | Q04400 | CHEMBL2880 | Adenylate Cyclase Type V, Rat | 62 | 29 | 5 | 6 |
UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
---|---|---|---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 75 | 8 | 8 | 7 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 30 | 7 | 7 | 6 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 | 1 | 1 | 0 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 | 0 | 0 | 0 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 | 1 | 1 | 0 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 | 1 | 1 | 0 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 30 | 7 | 7 | 6 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 | 1 | 1 | 0 |
ADCYA_HUMAN | Q96PN6 | CHEMBL5854 | Adenylate Cyclase Type 10, Human | 5 | 4 | 1 | 1 |
Code | Description | Substances | Purchasable | Natural | In Man |
---|---|---|---|---|---|
ADCY5-1-E | Adenylate Cyclase Type V (cluster #1 Of 2), Eukaryotic | 40 | 16 | 3 | 3 |
ADCY5-2-E | Adenylate Cyclase Type V (cluster #2 Of 2), Eukaryotic | 69 | 15 | 3 | 3 |
Uniprot | Swissprot | Chembl | Description | Number Shared |
---|---|---|---|---|
ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
ADCY3_HUMAN | O60266 | CHEMBL3164 | Adenylate Cyclase Type III, Human | 24 |
ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
GLR_HUMAN | P47871 | CHEMBL1985 | Glucagon Receptor, Human | 23 |
DRD1_RAT | P18901 | CHEMBL265 | Dopamine D1 Receptor, Rat | 10 |
DRD2_RAT | P61169 | CHEMBL339 | Dopamine D2 Receptor, Rat | 6 |
5HT2A_RAT | P14842 | CHEMBL322 | Serotonin 2a (5-HT2a) Receptor, Rat | 3 |
5HT2B_RAT | P30994 | CHEMBL323 | Serotonin 2b (5-HT2b) Receptor, Rat | 3 |
5HT2C_RAT | P08909 | CHEMBL324 | Serotonin 2c (5-HT2c) Receptor, Rat | 3 |
ADA2A_HUMAN | P08913 | CHEMBL1867 | Alpha-2a Adrenergic Receptor, Human | 3 |
5HT1A_RAT | P19327 | CHEMBL273 | Serotonin 1a (5-HT1a) Receptor, Rat | 2 |
5HT2C_HUMAN | P28335 | CHEMBL225 | Serotonin 2c (5-HT2c) Receptor, Human | 2 |
ADA2A_RAT | P22909 | CHEMBL327 | Alpha-2a Adrenergic Receptor, Rat | 2 |
ADA2B_HUMAN | P18089 | CHEMBL1942 | Alpha-2b Adrenergic Receptor, Human | 2 |
ADA2C_HUMAN | P18825 | CHEMBL1916 | Alpha-2c Adrenergic Receptor, Human | 2 |
ADCY1_MOUSE | O88444 | CHEMBL3532 | Adenylate Cyclase Type I, Mouse | 2 |
ADCY2_MOUSE | Q80TL1 | CHEMBL3049 | Adenylate Cyclase Type II, Mouse | 2 |
ADCY2_RAT | P26769 | CHEMBL2958 | Adenylate Cyclase Type II, Rat | 2 |
ADCY3_MOUSE | Q8VHH7 | CHEMBL2920 | Adenylate Cyclase Type III, Mouse | 2 |
ADCY3_RAT | P21932 | CHEMBL4864 | Adenylate Cyclase Type III, Rat | 2 |
ADCY4_MOUSE | Q91WF3 | CHEMBL2556 | Adenylate Cyclase Type IV, Mouse | 2 |
ADCY4_RAT | P26770 | CHEMBL2879 | Adenylate Cyclase Type IV, Rat | 2 |
ADCY5_MOUSE | P84309 | CHEMBL2561 | Adenylate Cyclase Type V, Mouse | 2 |
ADCY5_RAT | Q04400 | CHEMBL2880 | Adenylate Cyclase Type V, Rat | 2 |
ADCY6_MOUSE | Q01341 | CHEMBL3015 | Adenylate Cyclase Type VI, Mouse | 2 |
ADCY6_RAT | Q03343 | CHEMBL2975 | Adenylate Cyclase Type VI, Rat | 2 |
ADCY7_MOUSE | P51829 | CHEMBL3016 | Adenylate Cyclase Type VII, Mouse | 2 |
ADCY8_MOUSE | P97490 | CHEMBL2961 | Adenylate Cyclase Type VIII, Mouse | 2 |
ADCY8_RAT | P40146 | CHEMBL3082 | Adenylate Cyclase Type VIII, Rat | 2 |
DRD1_HUMAN | P21728 | CHEMBL2056 | Dopamine D1 Receptor, Human | 2 |
DRD2_HUMAN | P14416 | CHEMBL217 | Dopamine D2 Receptor, Human | 2 |
DRD5_HUMAN | P21918 | CHEMBL1850 | Dopamine D5 Receptor, Human | 2 |
Q8CFM9_RAT | Q8CFM9 | CHEMBL3940 | Adenylate Cyclase Type VII, Rat | 2 |
AA1R_HUMAN | P30542 | CHEMBL226 | Adenosine A1 Receptor, Human | 1 |
AA1R_RAT | P25099 | CHEMBL318 | Adenosine A1 Receptor, Rat | 1 |
AA2AR_CAVPO | P46616 | CHEMBL2605 | Adenosine A2a Receptor, Guinea Pig | 1 |
AA2AR_HUMAN | P29274 | CHEMBL251 | Adenosine A2a Receptor, Human | 1 |
AA2AR_RAT | P30543 | CHEMBL302 | Adenosine A2a Receptor, Rat | 1 |
AA2BR_HUMAN | P29275 | CHEMBL255 | Adenosine A2b Receptor, Human | 1 |
AA2BR_RAT | P29276 | CHEMBL2592 | Adenosine A2b Receptor, Rat | 1 |
AA3R_HUMAN | P33765 | CHEMBL256 | Adenosine A3 Receptor, Human | 1 |
ADA1A_HUMAN | P35348 | CHEMBL229 | Alpha-1a Adrenergic Receptor, Human | 1 |
ADA1B_HUMAN | P35368 | CHEMBL232 | Alpha-1b Adrenergic Receptor, Human | 1 |
ADA1D_HUMAN | P25100 | CHEMBL223 | Alpha-1d Adrenergic Receptor, Human | 1 |
ADA2B_RAT | P19328 | CHEMBL266 | Alpha-2b Adrenergic Receptor, Rat | 1 |
ADA2C_RAT | P22086 | CHEMBL314 | Alpha-2c Adrenergic Receptor, Rat | 1 |
D4A3N4_RAT | D4A3N4 | CHEMBL2679 | Brain Adenylate Cyclase 1, Rat | 1 |
DRD1_BOVIN | Q95136 | CHEMBL2967 | Dopamine D1 Receptor, Bovin | 1 |
DRD1_MOUSE | Q61616 | CHEMBL3071 | Dopamine D1 Receptor, Mouse | 1 |
DRD1_PIG | P50130 | CHEMBL5067 | Dopamine D1 Receptor, Pig | 1 |
DRD2_MOUSE | P61168 | CHEMBL3427 | Dopamine D2 Receptor, Mouse | 1 |
DRD3_RAT | P19020 | CHEMBL3138 | Dopamine D3 Receptor, Rat | 1 |
DRD5_RAT | P25115 | CHEMBL2281 | Dopamine D5 Receptor, Rat | 1 |
GIPR_HUMAN | P48546 | CHEMBL4383 | Gastric Inhibitory Polypeptide Receptor, Human | 1 |
GIPR_RAT | P43219 | CHEMBL5001 | Gastric Inhibitory Polypeptide Receptor, Rat | 1 |
GLP1R_HUMAN | P43220 | CHEMBL1784 | Glucagon-like Peptide Receptor, Human | 1 |
GLR_RAT | P30082 | CHEMBL4720 | Glucagon Receptor, Rat | 1 |
SC6A3_HUMAN | Q01959 | CHEMBL238 | Dopamine Transporter, Human | 1 |
SC6A4_HUMAN | P31645 | CHEMBL228 | Serotonin Transporter, Human | 1 |
SC6A4_MOUSE | Q60857 | CHEMBL4642 | Serotonin Transporter, Mouse | 1 |