ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (760)
Reactome (2)
Related By:
Pathway (20)
Organism (3)
Gene (2)
Org. Clust. (1)
ChEMBL (147)
Rings (42)

Beta-1 Adrenergic Receptor, Human (760 Compounds)

Swissprot:: ADRB1_HUMAN
Stitch:: ADRB1_HUMAN
UniProt:: P08588
ChEMBL:: CHEMBL213
Reactome:: REACT_16927; REACT_19327
PDB:: ADRB1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	760	58	28	26
Binding ≤ 1μM	416	45	21	21
Functional ≤ 10μM	504	13	10	12

Reactome ID	Description	Species
REACT_16927	Adrenoceptors	Homo sapiens
REACT_19327	G alpha (s) signalling events	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	15
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	24
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	23
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	18
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	17
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	16
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	863
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	874

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	4
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	13
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	13
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	863
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	874
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	10
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	9
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	7
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADRB1_BOVIN	Q9TT96	CHEMBL2313	Beta-1 Adrenergic Receptor, Bovin	6	2	2	2
ADRB1_MOUSE	P34971	CHEMBL3440	Beta-1 Adrenergic Receptor, Mouse	16	0	0	0
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	279	42	32	24

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	834	83	38	41
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	495	33	9	11

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
ADRB1-1-E	Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic	702	38	29	16
ADRB1-2-E	Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic	345	52	25	28

Uniprot	Swissprot	Chembl	Description	Number Shared
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	860
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	614
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	30
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	23
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	22
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	22
ADRB2_CANFA	P54833	CHEMBL2289	Beta-2 Adrenergic Receptor, Canine	20
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	17
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	17
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	17
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	16
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	15
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	15
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	15
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	14
ADA2A_BOVIN	Q28838	CHEMBL4744	Alpha-2a Adrenergic Receptor, Bovin	14
ADRB3_CANFA	O02662	CHEMBL4400	Beta-3 Adrenergic Receptor, Canine	14
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	13
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	13
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	13
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	13
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	13
ADRB2_BOVIN	Q28044	CHEMBL3373	Beta-2 Adrenergic Receptor, Bovin	13
Z80088	Z80088	CHEMBL613853	CHO (Ovarian Cells)	13
ADRB2_RAT	P10608	CHEMBL3754	Beta-2 Adrenergic Receptor, Rat	11
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	11
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	10
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	10
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	10
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	10
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	9
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	9
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	9
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	9
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	9
Z50588	Z50588	CHEMBL373	Canis Familiaris	9
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	8
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	8
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	8
ADA1A_BOVIN	P18130	CHEMBL4892	Alpha-1a Adrenergic Receptor, Bovin	8
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	8
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	8
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	7
Z50512	Z50512	CHEMBL369	Cavia Porcellus	7
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	6
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	6
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	6
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	6
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	6
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	5
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	5
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	5
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	5
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	5
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	5
DRD1_MOUSE	Q61616	CHEMBL3071	Dopamine D1 Receptor, Mouse	5
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	5
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	4
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	4
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	4
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	4
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	4
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	4
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	4
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	4
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	4
NMT1_HUMAN	P30419	CHEMBL2593	Peptide N-myristoyltransferase 1, Human	4
NMT2_HUMAN	O60551	CHEMBL2849	Peptide N-myristoyltransferase 2, Human	4
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	4
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	4
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	4
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	4
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	4
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	4
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	3
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	3
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	3
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	3
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	3
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	3
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) Receptor, Human	2
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) Receptor, Human	2
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) Receptor, Human	2
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ADRB1_MOUSE	P34971	CHEMBL3440	Beta-1 Adrenergic Receptor, Mouse	2
ADRB2_MESAU	P04274	CHEMBL5943	Beta-2 Adrenergic Receptor, Mesau	2
ADRB2_MOUSE	P18762	CHEMBL3707	Beta-2 Adrenergic Receptor, Mouse	2
ADRB3_MOUSE	P25962	CHEMBL4030	Beta-3 Adrenergic Receptor, Mouse	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
FDFT_RAT	Q02769	CHEMBL3815	Squalene Synthetase, Rat	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
PKD1_HUMAN	P98161	CHEMBL5772	Polycystin-1, Human	2
PKD2_HUMAN	Q13563	CHEMBL5465	Polycystin-2, Human	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
Z50587	Z50587	CHEMBL372	Homo Sapiens	2
5HT5A_MOUSE	P30966	CHEMBL3597	Serotonin 5a (5-HT5a) Receptor, Mouse	1
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
ADA1A_RABIT	O02824	CHEMBL3637	Alpha-1a Adrenergic Receptor, Rabit	1
ADA1D_RABIT	O02666	CHEMBL4407	Alpha-1d Adrenergic Receptor, Rabit	1
ADA2B_BOVIN	O77700	CHEMBL3523	Alpha-2b Adrenergic Receptor, Bovin	1
ADCY2_RAT	P26769	CHEMBL2958	Adenylate Cyclase Type II, Rat	1
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	1
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	1
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	1
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	1
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	1
ADRB2_CAVPO	Q8K4Z4	CHEMBL5414	Beta-2 Adrenergic Receptor, Guinea Pig	1
CAC1C_HUMAN	Q13936	CHEMBL1940	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human	1
CAC1D_HUMAN	Q01668	CHEMBL4138	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human	1
CAC1F_HUMAN	O60840	CHEMBL5593	Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human	1
CAC1S_HUMAN	Q13698	CHEMBL3805	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human	1
CASR_HUMAN	P41180	CHEMBL1878	Calcium Sensing Receptor, Human	1
CXCR3_HUMAN	P49682	CHEMBL4441	C-X-C Chemokine Receptor Type 3, Human	1
CXCR3_MOUSE	O88410	CHEMBL5200	C-X-C Chemokine Receptor Type 3, Mouse	1
DRD1_PIG	P50130	CHEMBL5067	Dopamine D1 Receptor, Pig	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
KPCA_HUMAN	P17252	CHEMBL299	Protein Kinase C Alpha, Human	1
KPCD_HUMAN	Q05655	CHEMBL2996	Protein Kinase C Delta, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	1
OPRX_HUMAN	P41146	CHEMBL2014	Nociceptin Receptor, Human	1
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	1