ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (495)
Reactome (2)
Related By:
Pathway (18)
Organism (3)
Gene (2)
Org. Clust. (1)
ChEMBL (98)
Rings (29)

Beta-3 Adrenergic Receptor, Human (495 Compounds)

Swissprot:: ADRB3_HUMAN
Stitch:: ADRB3_HUMAN
UniProt:: P13945
ChEMBL:: CHEMBL246
Reactome:: REACT_16927; REACT_19327
PDB:: 2CDW (DOCK); ADRB3

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	495	33	9	11
Binding ≤ 1μM	374	16	5	7
Functional ≤ 10μM	1,150	19	7	9

Reactome ID	Description	Species
REACT_16927	Adrenoceptors	Homo sapiens
REACT_19327	G alpha (s) signalling events	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	7
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	9
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	9
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	8
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	8
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	7
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	874
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	687

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	874
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	687
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	3
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADRB3_BOVIN	P46626	CHEMBL3083	Beta-3 Adrenergic Receptor, Bovin	6	2	2	2
ADRB3_MOUSE	P25962	CHEMBL4030	Beta-3 Adrenergic Receptor, Mouse	17	0	0	0
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	208	29	27	20

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	760	58	28	26
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	834	83	38	41

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
ADRB3-1-E	Beta-3 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic	560	31	22	15
ADRB3-2-E	Beta-3 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic	164	29	13	13

Uniprot	Swissprot	Chembl	Description	Number Shared
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	614
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	416
Z80088	Z80088	CHEMBL613853	CHO (Ovarian Cells)	38
ADRB3_CANFA	O02662	CHEMBL4400	Beta-3 Adrenergic Receptor, Canine	26
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	19
Z50588	Z50588	CHEMBL373	Canis Familiaris	16
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	14
ADRB2_RAT	P10608	CHEMBL3754	Beta-2 Adrenergic Receptor, Rat	13
ADRB2_CANFA	P54833	CHEMBL2289	Beta-2 Adrenergic Receptor, Canine	11
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	7
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	7
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	6
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	6
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	6
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	6
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	6
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	5
Z50512	Z50512	CHEMBL369	Cavia Porcellus	5
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	4
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	4
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	4
CASR_HUMAN	P41180	CHEMBL1878	Calcium Sensing Receptor, Human	4
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	4
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	4
NMT1_HUMAN	P30419	CHEMBL2593	Peptide N-myristoyltransferase 1, Human	4
NMT2_HUMAN	O60551	CHEMBL2849	Peptide N-myristoyltransferase 2, Human	4
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	4
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	3
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	3
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	3
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	3
ADRB3_MOUSE	P25962	CHEMBL4030	Beta-3 Adrenergic Receptor, Mouse	3
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	3
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	3
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	3
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	3
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	3
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	2
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	2
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	2
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	2
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	2
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	2
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	2
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	2
ADRB1_MOUSE	P34971	CHEMBL3440	Beta-1 Adrenergic Receptor, Mouse	2
ADRB2_BOVIN	Q28044	CHEMBL3373	Beta-2 Adrenergic Receptor, Bovin	2
ADRB2_MESAU	P04274	CHEMBL5943	Beta-2 Adrenergic Receptor, Mesau	2
ADRB2_MOUSE	P18762	CHEMBL3707	Beta-2 Adrenergic Receptor, Mouse	2
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	2
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	2
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	2
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	2
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	2
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	2
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	2
FDFT_RAT	Q02769	CHEMBL3815	Squalene Synthetase, Rat	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	2
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	2
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	2
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	2
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	2
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
Z50587	Z50587	CHEMBL372	Homo Sapiens	2
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	2
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	1
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	1
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	1
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	1
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	1
ADA1A_RABIT	O02824	CHEMBL3637	Alpha-1a Adrenergic Receptor, Rabit	1
ADA1D_RABIT	O02666	CHEMBL4407	Alpha-1d Adrenergic Receptor, Rabit	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
GHSR_HUMAN	Q92847	CHEMBL4616	Ghrelin Receptor, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	1
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	1