UCSF

Aldo-keto Reductase Family 1 Member C1, Human (17 Compounds)

Swissprot:
AK1C1_HUMAN
Stitch:
AK1C1_HUMAN
UniProt:
Q04828
ChEMBL:
CHEMBL5905
Reactome:
REACT_24968
REACT_11053
REACT_11048
REACT_11041
PDB:
1MRQ (DOCK)
3C3U (DOCK)
3GUG (DOCK)
3NTY (DOCK)
AKR1C1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 17 6 2 1
Binding ≤ 1μM 17 6 2 1

Reactome Network (4)

Reactome ID Description Species
REACT_24968 Retinoid metabolism and transport Homo sapiens
REACT_11053 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Homo sapiens
REACT_11048 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Homo sapiens
REACT_11041 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
AK1C2_HUMAN P52895 CHEMBL5847 Aldo-keto Reductase Family 1 Member C2, Human 15
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
AK1C2_HUMAN P52895 CHEMBL5847 Aldo-keto Reductase Family 1 Member C2, Human 15
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
AK1C2_HUMAN P52895 CHEMBL5847 Aldo-keto Reductase Family 1 Member C2, Human 15
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AK1C2_HUMAN P52895 CHEMBL5847 Aldo-keto Reductase Family 1 Member C2, Human 19 9 3 1
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 37 13 4 4

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
AK1C2_HUMAN P52895 CHEMBL5847 Aldo-keto Reductase Family 1 Member C2, Human 15
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
S22AC_HUMAN Q96S37 CHEMBL6120 Solute Carrier Family 22 Member 12, Human 1