UCSF

Aldose Reductase, Human (630 Compounds)

Swissprot:
ALDR_HUMAN
Stitch:
ALDR_HUMAN
UniProt:
P15121
ChEMBL:
CHEMBL1900
Reactome:
REACT_11038
PDB:
1ABN (DOCK)
1ADS (DOCK)
1AZ1 (DOCK)
1AZ2 (DOCK)
1EF3 (DOCK)
1EL3 (DOCK)
1IEI (DOCK)
1MAR (DOCK)
1PWL (DOCK)
1PWM (DOCK)
1T40 (DOCK)
1T41 (DOCK)
1US0 (DOCK)
1X96 (DOCK)
1X97 (DOCK)
1X98 (DOCK)
1XGD (DOCK)
1Z3N (DOCK)
1Z89 (DOCK)
1Z8A (DOCK)
2ACQ (DOCK)
2ACR (DOCK)
2ACS (DOCK)
2ACU (DOCK)
2AGT (DOCK)
2DUX (DOCK)
2DUZ (DOCK)
2DV0 (DOCK)
2F2K (DOCK)
2FZ8 (DOCK)
2FZ9 (DOCK)
2FZB (DOCK)
2FZD (DOCK)
2HV5 (DOCK)
2HVN (DOCK)
2HVO (DOCK)
2I16 (DOCK)
2I17 (DOCK)
2IKG (DOCK)
2IKH (DOCK)
2IKI (DOCK)
2IKJ (DOCK)
2INE (DOCK)
2INZ (DOCK)
2IPW (DOCK)
2IQ0 (DOCK)
2IQD (DOCK)
2IS7 (DOCK)
2ISF (DOCK)
2J8T (DOCK)
2NVC (DOCK)
2NVD (DOCK)
2PD5 (DOCK)
2PD9 (DOCK)
2PDB (DOCK)
2PDC (DOCK)
2PDF (DOCK)
2PDG (DOCK)
2PDH (DOCK)
2PDI (DOCK)
2PDJ (DOCK)
2PDK (DOCK)
2PDL (DOCK)
2PDM (DOCK)
2PDN (DOCK)
2PDP (DOCK)
2PDQ (DOCK)
2PDU (DOCK)
2PDW (DOCK)
2PDX (DOCK)
2PDY (DOCK)
2PEV (DOCK)
2PF8 (DOCK)
2PFH (DOCK)
2PZN (DOCK)
2QXW (DOCK)
2R24 (DOCK)
3BCJ (DOCK)
3DN5 (DOCK)
3G5E (DOCK)
3GHR (DOCK)
3GHS (DOCK)
3GHT (DOCK)
3GHU (DOCK)
3LBO (DOCK)
3LD5 (DOCK)
3LEN (DOCK)
3LEP (DOCK)
3LQG (DOCK)
3LQL (DOCK)
3LZ3 (DOCK)
3LZ5 (DOCK)
3M0I (DOCK)
3M4H (DOCK)
3M64 (DOCK)
3MB9 (DOCK)
3MC5 (DOCK)
3ONB (DOCK)
3ONC (DOCK)
3P2V (DOCK)
3Q65 (DOCK)
3Q67 (DOCK)
3RX2 (DOCK)
3RX3 (DOCK)
3RX4 (DOCK)
3T42 (DOCK)
3U2C (DOCK)
AKR1B1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 630 58 22 25
Binding ≤ 1μM 471 34 16 23
Functional ≤ 10μM 1 1 1 1

Reactome Network (1)

Reactome ID Description Species
REACT_11038 Pregnenolone biosynthesis Homo sapiens
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 210 42 11 7
ALDR_PIG P80276 CHEMBL4559 Aldose Reductase, Pig 100 8 6 6
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 274 92 48 15

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
ALDR-1-E Aldose Reductase (cluster #1 Of 5), Eukaryotic 907 102 54 18
ALDR-2-E Aldose Reductase (cluster #2 Of 5), Eukaryotic 245 65 6 9
ALDR-3-E Aldose Reductase (cluster #3 Of 5), Eukaryotic 8 0 0 0
ALDR-4-E Aldose Reductase (cluster #4 Of 5), Eukaryotic 21 3 1 1
ALDR-5-E Aldose Reductase (cluster #5 Of 5), Eukaryotic 3 3 2 2
Uniprot Swissprot Chembl Description Number Shared
AK1A1_HUMAN P14550 CHEMBL2246 Aldehyde Reductase, Human 23
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 19
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 15
AK1BA_HUMAN O60218 CHEMBL5983 Aldo-keto Reductase Family 1 Member B10, Human 9
AK1A1_PIG P50578 CHEMBL4049 Aldehyde Reductase, Pig 7
ALDR_PIG P80276 CHEMBL4559 Aldose Reductase, Pig 7
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 5
LDHA_HUMAN P00338 CHEMBL4835 L-lactate Dehydrogenase A Chain, Human 4
LDHB_HUMAN P07195 CHEMBL4940 L-lactate Dehydrogenase B Chain, Human 4
LDHC_HUMAN P07864 CHEMBL4173 L-lactate Dehydrogenase C Chain, Human 4
LDHD_HUMAN Q86WU2 CHEMBL2255 D-lactate Dehydrogenase, Human 4
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 3
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 2
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 2
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 2
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 2
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 2
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 2
PPBT_RAT P08289 CHEMBL2729 Alkaline Phosphatase Tissue-nonspecific, Rat 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDH2_HUMAN P05091 CHEMBL1935 Aldehyde Dehydrogenase, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 1
BAD_HUMAN Q92934 CHEMBL3817 Bcl2-antagonist Of Cell Death (BAD), Human 1
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DHB3_HUMAN P37058 CHEMBL4234 Estradiol 17-beta-dehydrogenase 3, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 1
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MCL1_HUMAN Q07820 CHEMBL4361 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Human 1
MDHC_PIG P11708 CHEMBL4048 Malate Dehydrogenase Cytoplasmic, Pig 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 1
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 1
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 1
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 1
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 1
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
Q0PJ46_PLAFA Q0PJ46 CHEMBL6071 Lactate Dehydrogenase, Plafa 1
Q6VVP7_PLAFA Q6VVP7 CHEMBL6072 Malate Dehydrogenase, Plafa 1
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1

Most Common Rings