UCSF

Gamma-secretase Subunit APH-1B, Mouse (3 Compounds)

Swissprot:
APH1B_MOUSE
Stitch:
APH1B_MOUSE
UniProt:
Q8C7N7
ChEMBL:
CHEMBL3786
Reactome:
REACT_199384
REACT_196591
REACT_196589
REACT_243590
REACT_199411
REACT_202271
REACT_198574
REACT_218614
REACT_199413
REACT_199404
PDB:
Aph1b

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Functional ≤ 10μM 3 0 0 0

Reactome Network (10)

Reactome ID Description Species
REACT_199384 Activated NOTCH1 Transmits Signal to the Nucleus Mus musculus
REACT_196591 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mus musculus
REACT_196589 Constitutive Signaling by NOTCH1 PEST Domain Mutants Mus musculus
REACT_243590 EPH-ephrin mediated repulsion of cells Mus musculus
REACT_199411 NOTCH2 Activation and Transmission of Signal to the Nucleus Mus musculus
REACT_202271 NRIF signals cell death from the nucleus Mus musculus
REACT_198574 Nuclear signaling by ERBB4 Mus musculus
REACT_218614 Regulated proteolysis of p75NTR Mus musculus
REACT_199413 Signaling by NOTCH3 Mus musculus
REACT_199404 Signaling by NOTCH4 Mus musculus
Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

EPH-ephrin mediated repulsion of cells

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

NOTCH2 Activation and Transmission of Signal to the Nucleus

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

NRIF signals cell death from the nucleus

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Nuclear signaling by ERBB4

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Regulated proteolysis of p75NTR

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Signaling by NOTCH3

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Signaling by NOTCH4

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 3
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 3
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 3
PSN1_MOUSE P49769 CHEMBL5128 Presenilin-1, Mouse 3
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 3
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 3
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 2
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 1