UCSF

Caspase-8, Human (444 Compounds)

Swissprot:
CASP8_HUMAN
Stitch:
CASP8_HUMAN
UniProt:
Q14790
ChEMBL:
CHEMBL3776
Reactome:
REACT_701
REACT_107
REACT_995
REACT_1503
REACT_13541
REACT_832
REACT_900
REACT_25039
REACT_75776
REACT_164011
REACT_402
REACT_150361
PDB:
1F9E (DOCK)
1I4E (DOCK)
1QDU (DOCK)
1QTN (DOCK)
2C2Z (DOCK)
2FUN (DOCK)
2K7Z (DOCK)
2Y1L (DOCK)
3H11 (DOCK)
3KJN (DOCK)
3KJQ (DOCK)
CASP8

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 444 4 1 2
Binding ≤ 1μM 246 3 1 2

Reactome Network (12)

Reactome ID Description Species
REACT_701 Activation, myristolyation of BID and translocation to mitochondria Homo sapiens
REACT_107 Apoptotic cleavage of cellular proteins Homo sapiens
REACT_995 Apoptotic execution phase Homo sapiens
REACT_1503 Caspase-8 activation by cleavage Homo sapiens
REACT_13541 Caspase-mediated cleavage of cytoskeletal proteins Homo sapiens
REACT_832 Dimerization of procaspase-8 Homo sapiens
REACT_900 FasL/ CD95L signaling Homo sapiens
REACT_25039 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Homo sapiens
REACT_75776 NOD1/2 Signaling Pathway Homo sapiens
REACT_164011 Regulation by c-FLIP Homo sapiens
REACT_402 TRAIL signaling Homo sapiens
REACT_150361 TRIF-mediated programmed cell death Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GRAB_HUMAN P10144 CHEMBL2316 Granzyme B, Human 1

Apoptotic cleavage of cellular proteins

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 293
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 98
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 218

Caspase-mediated cleavage of cytoskeletal proteins

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 293
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 98
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 218

FasL/ CD95L signaling

Uniprot Swissprot Chembl Description Number Shared
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

Uniprot Swissprot Chembl Description Number Shared
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4

NOD1/2 Signaling Pathway

Uniprot Swissprot Chembl Description Number Shared
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 417
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 9
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 4
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11

TRAIL signaling

Uniprot Swissprot Chembl Description Number Shared
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 975 16 2 1
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 75 2 1 2
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 987 29 1 5
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 5 0 0 0
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4 0 0 0
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 171 7 0 1
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433 10 0 2
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11 2 0 0
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4 0 0 0
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 417
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 293
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 218
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 98
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 9
CASP1_MOUSE P29452 CHEMBL4800 Caspase-1, Mouse 7
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 4
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 2
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 2
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 2
GRAB_HUMAN P10144 CHEMBL2316 Granzyme B, Human 1

Most Common Rings