UCSF

Cathepsin L, Human (980 Compounds)

Swissprot:
CATL1_HUMAN
Stitch:
CATL1_HUMAN
UniProt:
P07711
ChEMBL:
CHEMBL3837
Reactome:
REACT_150180
REACT_150401
REACT_118572
REACT_111168
REACT_121399
REACT_118632
PDB:
1CJL (DOCK)
1CS8 (DOCK)
1ICF (DOCK)
1MHW (DOCK)
2NQD (DOCK)
2VHS (DOCK)
2XU1 (DOCK)
2XU3 (DOCK)
2XU4 (DOCK)
2XU5 (DOCK)
2YJ2 (DOCK)
2YJ8 (DOCK)
2YJ9 (DOCK)
2YJB (DOCK)
2YJC (DOCK)
3BC3 (DOCK)
3H89 (DOCK)
3H8B (DOCK)
3H8C (DOCK)
3HHA (DOCK)
3HWN (DOCK)
3IV2 (DOCK)
3K24 (DOCK)
3KSE (DOCK)
3OF8 (DOCK)
3OF9 (DOCK)
CTSL1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 980 26 7 16
Binding ≤ 1μM 677 17 4 10
Functional ≤ 10μM 1 0 0 0

Reactome Network (6)

Reactome ID Description Species
REACT_150180 Assembly of collagen fibrils and other multimeric structures Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_111168 Endosomal/Vacuolar pathway Homo sapiens
REACT_121399 MHC class II antigen presentation Homo sapiens
REACT_118632 Trafficking and processing of endosomal TLR Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 423
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 577

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 423
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 564
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 4

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 14
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 2
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 564
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 577
CPNS1_HUMAN P04632 CHEMBL4962 Calpain Small Subunit 1, Human 6
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 4
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1

Endosomal/Vacuolar pathway

Uniprot Swissprot Chembl Description Number Shared
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 577

MHC class II antigen presentation

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 423
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 25
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 1
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 28
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 19
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 564
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 577

Trafficking and processing of endosomal TLR

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 423
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 564
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 577
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CATL1_BOVIN P25975 CHEMBL2113 Cathepsin L, Bovin 29 5 0 0
CATL1_MOUSE P06797 CHEMBL5291 Cathepsin L1, Mouse 9 0 0 1
CATL1_RAT P07154 CHEMBL2305 Cathepsin L, Rat 26 0 0 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 111 8 9 4

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
CATL1-1-E Cathepsin L (cluster #1 Of 5), Eukaryotic 881 23 5 13
CATL1-2-E Cathepsin L (cluster #2 Of 5), Eukaryotic 4 2 2 2
CATL1-3-E Cathepsin L (cluster #3 Of 5), Eukaryotic 15 1 0 0
CATL1-4-E Cathepsin L (cluster #4 Of 5), Eukaryotic 8 1 0 0
CATL1-5-E Cathepsin L (cluster #5 Of 5), Eukaryotic 121 2 0 1
Uniprot Swissprot Chembl Description Number Shared
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 577
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 564
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 423
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 88
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 64
Q95PM0_TRYBR Q95PM0 CHEMBL4188 Rhodesain, Trybr 34
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 28
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 25
Q6R7Z5_9TRYP Q6R7Z5 CHEMBL5832 Cathepsin B-like Cysteine Protease, 9tryp 23
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 19
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 16
CATS_MOUSE O70370 CHEMBL4098 Cathepsin S, Mouse 16
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 14
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 14
CATK_RABIT P43236 CHEMBL3349 Cathepsin K, Rabit 12
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 12
CATB_MOUSE P10605 CHEMBL5187 Cathepsin B, Mouse 9
CATL1_MOUSE P06797 CHEMBL5291 Cathepsin L1, Mouse 9
CATL1_RAT P07154 CHEMBL2305 Cathepsin L, Rat 9
CATS_RAT Q02765 CHEMBL1075217 Cathepsin S, Rat 9
CAN2_HUMAN P17655 CHEMBL2382 Calpain 2, Human 7
CATK_MOUSE P55097 CHEMBL1075277 Cathepsin K, Mouse 7
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 7
Z50587 Z50587 CHEMBL372 Homo Sapiens 7
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 6
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 6
CATB_BOVIN P07688 CHEMBL2323 Cathepsin B, Bovin 4
CATK_RAT O35186 CHEMBL3034 Cathepsin K, Rat 4
CATL1_BOVIN P25975 CHEMBL2113 Cathepsin L, Bovin 4
CATZ_HUMAN Q9UBR2 CHEMBL4160 Cathepsin Z, Human 4
CPNS1_HUMAN P04632 CHEMBL4962 Calpain Small Subunit 1, Human 4
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 4
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 4
CAN1_PIG P35750 CHEMBL4062 Calpain 1, Pig 3
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
CPNS1_PIG P04574 CHEMBL2205 Calpain Small Subunit 1, Pig 3
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3
PTN13_HUMAN Q12923 CHEMBL2976 Protein-tyrosine Phosphatase 1E, Human 3
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 3
A3EZI9_9HEPC A3EZI9 CHEMBL4893 Hepatitis C Virus NS3 Protease/helicase, 9hepc 2
CAN1_MOUSE O35350 CHEMBL4210 Calpain 1, Mouse 2
CAN2_CHICK Q92178 CHEMBL5563 Calpain 2, Chick 2
CANX_CHICK P00789 CHEMBL3147 Calpain 1/2, Chick 2
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 2
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 2
CATL3_PARTE Q94715 CHEMBL4097 Cathepsin L2, Parte 2
CPNS1_MOUSE O88456 CHEMBL4209 Calpain Small Subunit 1, Mouse 2
ELNE_MOUSE Q3UP87 CHEMBL5156 Neutrophil Elastase, Mouse 2
LMCPB_LEIME P36400 CHEMBL3821 Cysteine Proteinase B, Leime 2
PRTN3_MOUSE Q61096 CHEMBL5384 Myeloblastin, Mouse 2
Q3HTL5_PLAFA Q3HTL5 CHEMBL3488 Falcipain 2B, Plafa 2
Q95WR6_LEIDO Q95WR6 CHEMBL4751 Cysteine Protease, Leido 2
Q9NBA7_PLAFA Q9NBA7 CHEMBL4510 Cysteine Protease Falcipain-3, Plafa 2
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 2
TRPA1_HUMAN O75762 CHEMBL6007 Transient Receptor Potential Cation Channel Subfamily A Member 1, Human 2
TRPA1_MOUSE Q8BLA8 CHEMBL1075310 Transient Receptor Potential Cation Channel Subfamily A Member 1, Mouse 2
Z100494 Z100494 CHEMBL612655 C2C12 (Myoblast Cells) 2
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 1
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1
CATD_BOVIN P80209 CHEMBL4106 Cathepsin D, Bovin 1
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 1
CATG_MOUSE P28293 CHEMBL5622 Cathepsin G, Mouse 1
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 1
D2K2A8_9HEPC D2K2A8 CHEMBL2364 Hepatitis C Virus NS4A Protein, 9hepc 1
KLK4_HUMAN Q9Y5K2 CHEMBL4446 Kallikrein 4, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
PEPA_HUMAN P00790 CHEMBL3295 Pepsin A, Human 1
PEPA_PIG P00791 CHEMBL2714 Pepsin A, Pig 1
PLM2_PLAFA P46925 CHEMBL4414 Plasmepsin 2, Plafa 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q9NAW4_PLAFA Q9NAW4 CHEMBL1697661 Cysteine Protease Falcipain-3, Plafa 1
Q9NBD4_PLAFA Q9NBD4 CHEMBL5801 Cysteine Protease Falcipain-2, Plafa 1
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
RENI_RAT P08424 CHEMBL2322 Renin, Rat 1
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 1
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 1

Most Common Rings