UCSF

Butyrylcholinesterase, Human (1,110 Compounds)

Swissprot:
CHLE_HUMAN
Stitch:
CHLE_HUMAN
UniProt:
P06276
ChEMBL:
CHEMBL1914
Reactome:
REACT_13583
REACT_121238
REACT_19189
PDB:
1EHO (DOCK)
1EHQ (DOCK)
1KCJ (DOCK)
1P0I (DOCK)
1P0M (DOCK)
1P0P (DOCK)
1P0Q (DOCK)
1XLU (DOCK)
1XLV (DOCK)
1XLW (DOCK)
2J4C (DOCK)
2PM8 (DOCK)
2WID (DOCK)
2WIF (DOCK)
2WIG (DOCK)
2WIJ (DOCK)
2WIK (DOCK)
2WIL (DOCK)
2WSL (DOCK)
2XMB (DOCK)
2XMC (DOCK)
2XMD (DOCK)
2XMG (DOCK)
2XQF (DOCK)
2XQG (DOCK)
2XQI (DOCK)
2XQJ (DOCK)
2XQK (DOCK)
2Y1K (DOCK)
3DJY (DOCK)
3DKK (DOCK)
3O9M (DOCK)
BCHE

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,110 89 31 18
Binding ≤ 1μM 694 45 22 14

Reactome Network (3)

Reactome ID Description Species
REACT_13583 Neurotransmitter Clearance In The Synaptic Cleft Homo sapiens
REACT_121238 Synthesis of PC Homo sapiens
REACT_19189 Synthesis, secretion, and deacylation of Ghrelin Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 695

Synthesis of PC

Uniprot Swissprot Chembl Description Number Shared
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 695
CHKA_HUMAN P35790 CHEMBL3117 Choline Kinase Alpha, Human 2

Synthesis, secretion, and deacylation of Ghrelin

Uniprot Swissprot Chembl Description Number Shared
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 695
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CHLE_HORSE P81908 CHEMBL5763 Cholinesterase, Horse 352 22 16 15
CHLE_MOUSE Q03311 CHEMBL2528 Butyrylcholinesterase, Mouse 60 3 3 5

Clustered By Gene (0)

Clustered By Organism (6)

Code Description Substances Purchasable Natural In Man
CHLE-1-E Butyrylcholinesterase (cluster #1 Of 7), Eukaryotic 1,163 74 29 20
CHLE-2-E Butyrylcholinesterase (cluster #2 Of 7), Eukaryotic 181 24 11 8
CHLE-3-E Butyrylcholinesterase (cluster #3 Of 7), Eukaryotic 81 0 0 0
CHLE-4-E Butyrylcholinesterase (cluster #4 Of 7), Eukaryotic 0 0 0 0
CHLE-5-E Butyrylcholinesterase (cluster #5 Of 7), Eukaryotic 4 3 2 0
CHLE-6-E Butyrylcholinesterase (cluster #6 Of 7), Eukaryotic 83 1 0 0
CHLE-7-E Butyrylcholinesterase (cluster #7 Of 7), Eukaryotic 1 1 0 0
Uniprot Swissprot Chembl Description Number Shared
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 695
ACES_BOVIN P23795 CHEMBL4768 Acetylcholinesterase, Bovin 160
ACES_ELEEL O42275 CHEMBL4078 Acetylcholinesterase, Eleel 77
ACES_RAT P37136 CHEMBL3199 Acetylcholinesterase, Rat 43
ACM1_MOUSE P12657 CHEMBL3733 Muscarinic Acetylcholine Receptor M1, Mouse 31
Q9N1N9_HORSE Q9N1N9 CHEMBL5077 Butyrylcholinesterase, Horse 30
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 27
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 26
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 24
CHLE_HORSE P81908 CHEMBL5763 Cholinesterase, Horse 23
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 20
ACM2_MOUSE Q9ERZ4 CHEMBL3197 Muscarinic Acetylcholine Receptor M2, Mouse 17
LIPS_HUMAN Q05469 CHEMBL3590 Hormone Sensitive Lipase, Human 17
LIPS_RAT P15304 CHEMBL5582 Hormone-sensitive Lipase, Rat 17
Q9JKC1_RAT Q9JKC1 CHEMBL3403 Butyrylcholinesterase, Rat 14
EST1_HUMAN P23141 CHEMBL2265 Acyl Coenzyme A:cholesterol Acyltransferase, Human 11
ACES_MOUSE P21836 CHEMBL3198 Acetylcholinesterase, Mouse 9
ACHA7_RAT Q05941 CHEMBL4980 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat 9
CHLE_MOUSE Q03311 CHEMBL2528 Butyrylcholinesterase, Mouse 9
Q8WMX0_BOVIN Q8WMX0 CHEMBL2672 Muscarinic Acetylcholine Receptor M1, Bovin 6
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 5
EST2_HUMAN O00748 CHEMBL3180 Carboxylesterase 2, Human 4
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 3
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 3
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 3
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 3
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 3
CLAT_RAT P32738 CHEMBL3945 Choline Acetylase, Rat 3
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 3
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 3
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 2
CHKA_HUMAN P35790 CHEMBL3117 Choline Kinase Alpha, Human 2
EST1_RABIT P12337 CHEMBL2623 Acyl Coenzyme A:cholesterol Acyltransferase, Rabit 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 1
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 1
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 1
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 1
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ACHE_HUMAN Q04844 CHEMBL2484 Acetylcholine Receptor Protein Epsilon Chain, Human 1
ACM2_PIG P06199 CHEMBL4781 Muscarinic Acetylcholine Receptor M2, Pig 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 1
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 1
HNMT_RAT Q01984 CHEMBL3241 Histamine N-methyltransferase, Rat 1
I23O1_HUMAN P14902 CHEMBL4685 Indoleamine 2,3-dioxygenase, Human 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1
Z104298 Z104298 CHEMBL1907604 Glutamate NMDA Receptor; GRIN1/GRIN2A 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1

Most Common Rings