UCSF

Cytochrome P450 19A1, Human (1,848 Compounds)

Swissprot:
CP19A_HUMAN
Stitch:
CP19A_HUMAN
UniProt:
P11511
ChEMBL:
CHEMBL1978
Reactome:
REACT_13812
REACT_11037
PDB:
1TQA (DOCK)
3EQM (DOCK)
CYP19A1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,848 178 71 42
Binding ≤ 1μM 1,308 123 49 35
Functional ≤ 10μM 7 2 2 2

Reactome Network (2)

Reactome ID Description Species
REACT_13812 Endogenous sterols Homo sapiens
REACT_11037 Estrogen biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
C11B1_HUMAN P15538 CHEMBL1908 Cytochrome P450 11B1, Human 78
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 98
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 53
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 6
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 2
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 5

Estrogen biosynthesis

Uniprot Swissprot Chembl Description Number Shared
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CP19A_RAT P22443 CHEMBL3859 Cytochrome P450 19A1, Rat 126 15 9 6

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
CP19A-1-E Cytochrome P450 19A1 (cluster #1 Of 3), Eukaryotic 699 93 45 19
CP19A-2-E Cytochrome P450 19A1 (cluster #2 Of 3), Eukaryotic 804 34 11 6
CP19A-3-E Cytochrome P450 19A1 (cluster #3 Of 3), Eukaryotic 543 69 23 22
Uniprot Swissprot Chembl Description Number Shared
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 98
C11B1_HUMAN P15538 CHEMBL1908 Cytochrome P450 11B1, Human 78
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 53
STS_HUMAN P08842 CHEMBL3559 Steryl-sulfatase Precursor, Human 33
CP17A_RAT P11715 CHEMBL4430 Cytochrome P450 17A1, Rat 28
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 23
CP4AB_HUMAN Q02928 CHEMBL3978 Cytochrome P450 4A11, Human 14
CP4F2_HUMAN P78329 CHEMBL3379 Cytochrome P450 4F2, Human 14
CP19A_RAT P22443 CHEMBL3859 Cytochrome P450 19A1, Rat 13
NQO2_HUMAN P16083 CHEMBL3959 Quinone Reductase 2, Human 8
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 7
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 7
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 5
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 5
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 5
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 5
S5A1_HUMAN P18405 CHEMBL1787 Steroid 5-alpha-reductase 1, Human 5
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 5
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 4
CP11A_BOVIN P00189 CHEMBL4813 Cytochrome P450 11A1, Bovin 4
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 4
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 4
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 4
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 4
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 4
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 4
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 4
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 4
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 4
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 3
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 3
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 3
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 3
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 3
CP51A_RAT Q64654 CHEMBL4981 Cytochrome P450 51, Rat 3
CP51_MYCTU P0A512 CHEMBL5090 Lanosterol 14-alpha Demethylase, Myctu 3
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 3
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 3
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 3
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 3
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 3
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 3
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 3
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 3
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 3
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 3
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 3
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 3
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 3
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 3
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 3
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 3
Q9BEG3_BOVIN Q9BEG3 CHEMBL2980 Arachidonate 5-lipoxygenase, Bovin 3
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 2
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 2
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 2
ANDR_RAT P15207 CHEMBL3072 Androgen Receptor, Rat 2
C11B1_BOVIN P15150 CHEMBL2927 Cytochrome P450 11B1, Bovin 2
C11B1_RAT P15393 CHEMBL4970 Cytochrome P450 11B1, Rat 2
C11B2_RAT P30099 CHEMBL3237 Cytochrome P450 11B2, Rat 2
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 2
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 2
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 2
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 2
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 2
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 2
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 2
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 2
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 2
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 2
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 2
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 2
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 2
CP11A_RAT P14137 CHEMBL5246 Cytochrome P450 11A1, Rat 2
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 2
CP26A_HUMAN O43174 CHEMBL5141 Cytochrome P450 26A1, Human 2
CP7A1_RAT P18125 CHEMBL2339 Cytochrome P450 7A1, Rat 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 2
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 2
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 2
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
Z50740 Z50740 CHEMBL612361 Cricetinae Gen. Sp. 2
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CP24A_HUMAN Q07973 CHEMBL4521 Cytochrome P450 24A1, Human 1
CP4AA_RAT P08516 CHEMBL2681 Cytochrome P450 4A1, Rat 1
CP4AE_RAT P20817 CHEMBL2180 Cytochrome P450 4A3, Rat 1
DHB3_HUMAN P37058 CHEMBL4234 Estradiol 17-beta-dehydrogenase 3, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
FAS_HUMAN P49327 CHEMBL4158 Fatty Acid Synthase, Human 1
FPS_FUJSV P00530 CHEMBL5708 Tyrosine-protein Kinase Transforming Protein FPS, Fujsv 1
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 1
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 1
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 1
GBRD_HUMAN O14764 CHEMBL3591 GABA Receptor Delta Subunit, Human 1
GBRE_HUMAN P78334 CHEMBL4635 GABA Receptor Epsilon Subunit, Human 1
GBRG1_HUMAN Q8N1C3 CHEMBL4044 GABA Receptor Gamma-1 Subunit, Human 1
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 1
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 1
GBRP_HUMAN O00591 CHEMBL3506 GABA Receptor Pi Subunit, Human 1
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HMOX1_RAT P06762 CHEMBL5035 Heme Oxygenase 1, Rat 1
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 1
KCNA3_HUMAN P22001 CHEMBL4633 Voltage-gated Potassium Channel Subunit Kv1.3, Human 1
KCNN4_HUMAN O15554 CHEMBL4305 Intermediate Conductance Calcium-activated Potassium Channel Protein 4, Human 1
KD4DL_HUMAN B2RXH2 CHEMBL1293226 Lysine-specific Demethylase 4D-like, Human 1
MCR_RAT P22199 CHEMBL3507 Mineralocorticoid Receptor, Rat 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 1
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PRGR_RABIT P06186 CHEMBL3456 Progesterone Receptor, Rabit 1
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1
Q4WNT5_ASPFU Q4WNT5 CHEMBL1681623 14-alpha Sterol Demethylase Cyp51A, Aspfu 1
Q96W81_ASPFM Q96W81 CHEMBL1681624 14-alpha Sterol Demethylase, Aspfm 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
S5A1_RAT P24008 CHEMBL3422 Steroid 5-alpha-reductase 1, Rat 1
S5A2_RAT P31214 CHEMBL5099 Steroid 5-alpha-reductase 2, Rat 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
SHBG_HUMAN P04278 CHEMBL3305 Testis-specific Androgen-binding Protein, Human 1
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1

Most Common Rings