UCSF

Estradiol 17-beta-dehydrogenase 1, Human (217 Compounds)

Swissprot:
DHB1_HUMAN
Stitch:
DHB1_HUMAN
UniProt:
P14061
ChEMBL:
CHEMBL3181
Reactome:
REACT_11037
REACT_160156
PDB:
1A27 (DOCK)
1BHS (DOCK)
1DHT (DOCK)
1EQU (DOCK)
1FDS (DOCK)
1FDT (DOCK)
1FDU (DOCK)
1FDV (DOCK)
1FDW (DOCK)
1I5R (DOCK)
1IOL (DOCK)
1JTV (DOCK)
1QYV (DOCK)
1QYW (DOCK)
1QYX (DOCK)
3DEY (DOCK)
3DHE (DOCK)
3HB4 (DOCK)
3HB5 (DOCK)
3KLM (DOCK)
3KLP (DOCK)
3KM0 (DOCK)
HSD17B1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 217 12 8 5
Binding ≤ 1μM 168 5 3 2
Functional ≤ 10μM 34 2 2 1

Reactome Network (2)

Reactome ID Description Species
REACT_11037 Estrogen biosynthesis Homo sapiens
REACT_160156 The canonical retinoid cycle in rods (twilight vision) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 183 4 4 3
DHB3_HUMAN P37058 CHEMBL4234 Estradiol 17-beta-dehydrogenase 3, Human 179 23 12 3
DHB7_HUMAN P56937 CHEMBL5999 3-keto-steroid Reductase, Human 4 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 89
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 7
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 5
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 4
DHI1_MOUSE P50172 CHEMBL3910 11-beta-hydroxysteroid Dehydrogenase 1, Mouse 4
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 3
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 3
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 3
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 3
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 3
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 3
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 2
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 2
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 2
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 2
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 2
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ERR1_HUMAN P11474 CHEMBL3429 Estrogen-related Receptor Alpha, Human 1
ERR2_HUMAN O95718 CHEMBL3751 Estrogen-related Receptor Beta, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
MGA_HUMAN O43451 CHEMBL2074 Maltase-glucoamylase, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
STS_HUMAN P08842 CHEMBL3559 Steryl-sulfatase Precursor, Human 1
TYRO_AGABI O42713 CHEMBL3318 Tyrosinase, Agabi 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1

Most Common Rings