UCSF

Dihydrofolate Reductase, Pneca (355 Compounds)

Swissprot:
DYR_PNECA
Stitch:
DYR_PNECA
UniProt:
P16184
ChEMBL:
CHEMBL1926
PDB:
1CD2 (DOCK)
1DAJ (DOCK)
1DYR (DOCK)
1E26 (DOCK)
1KLK (DOCK)
1LY3 (DOCK)
1LY4 (DOCK)
1S3Y (DOCK)
1VJ3 (DOCK)
2CD2 (DOCK)
2FZH (DOCK)
2FZI (DOCK)
3CD2 (DOCK)
3NZ6 (DOCK)
3NZ9 (DOCK)
3NZA (DOCK)
3NZB (DOCK)
3NZC (DOCK)
4CD2 (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 355 18 7 16
Binding ≤ 1μM 243 13 6 15

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 50 2 2 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 86 4 1 13
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 14 6 4 4
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 117 8 6 11
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 895 73 24 46
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 97 10 6 13
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 277 46 11 13
DYR_MYCTU P0A546 CHEMBL6065 Dihydrofolate Reductase, Myctu 1 1 1 1
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 585 34 8 19
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 33 3 3 4
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12 0 0 0
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 48 3 1 2

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
DYR-1-B Dihydrofolate Reductase (cluster #1 Of 4), Bacterial 237 18 13 24
DYR-1-E Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic 1,093 102 24 44
DYR-1-F Dihydrofolate Reductase (cluster #1 Of 1), Fungal 450 21 7 28
DYR-2-B Dihydrofolate Reductase (cluster #2 Of 4), Bacterial 2 0 0 0
DYR-2-E Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic 165 9 2 3
DYR-3-B Dihydrofolate Reductase (cluster #3 Of 4), Bacterial 1 1 1 1
DYR-3-E Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic 219 3 3 9
DYR-4-B Dihydrofolate Reductase (cluster #4 Of 4), Bacterial 7 0 0 1
Uniprot Swissprot Chembl Description Number Shared
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 335
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 329
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 130
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 54
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 39
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 20
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 11
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 4
B0BL08_ECOLX B0BL08 CHEMBL5441 Dihydrofolate Reductase, Ecolx 3
DRTS_PLAFK P13922 CHEMBL1939 Dihydrofolate Reductase, Plafk 3
DYR1_ECOLX P00382 CHEMBL2627 Dihydrofolate Reductase Type 1, Ecolx 3
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 3
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 2
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 2
FOLC_HUMAN Q05932 CHEMBL3171 Folylpoly-gamma-glutamate Synthetase, Human 2
PTR1_LEIMA Q01782 CHEMBL6194 Pteridine Reductase 1, Leima 2
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 2
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 2
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 2
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 1
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
Q5CGA3_CRYHO Q5CGA3 CHEMBL3327 Dihydrofolate Reductase, Cryho 1

Most Common Rings