UCSF

Acyl Coenzyme A:cholesterol Acyltransferase, Human (254 Compounds)

Swissprot:
EST1_HUMAN
Stitch:
EST1_HUMAN
UniProt:
P23141
ChEMBL:
CHEMBL2265
PDB:
1MX1 (DOCK)
1MX5 (DOCK)
1MX9 (DOCK)
1YA4 (DOCK)
1YA8 (DOCK)
1YAH (DOCK)
1YAJ (DOCK)
2DQY (DOCK)
2DQZ (DOCK)
2DR0 (DOCK)
2H7C (DOCK)
2HRQ (DOCK)
2HRR (DOCK)
3K9B (DOCK)
CES1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 254 88 22 5
Binding ≤ 1μM 181 51 12 2

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
EST1_PIG Q29550 CHEMBL3383 Carboxylesterase, Pig 31 2 2 2
EST1_RABIT P12337 CHEMBL2623 Acyl Coenzyme A:cholesterol Acyltransferase, Rabit 50 41 13 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
EST2_HUMAN O00748 CHEMBL3180 Carboxylesterase 2, Human 115 50 15 4

Clustered By Gene (0)

Clustered By Organism (6)

Code Description Substances Purchasable Natural In Man
EST1-1-E Carboxylesterase (cluster #1 Of 7), Eukaryotic 85 32 4 2
EST1-2-E Carboxylesterase (cluster #2 Of 7), Eukaryotic 23 8 1 0
EST1-3-E Carboxylesterase (cluster #3 Of 7), Eukaryotic 2 2 1 0
EST1-4-E Carboxylesterase (cluster #4 Of 7), Eukaryotic 3 3 1 0
EST1-5-E Carboxylesterase (cluster #5 Of 7), Eukaryotic 37 1 0 1
EST1-6-E Carboxylesterase (cluster #6 Of 7), Eukaryotic 126 48 16 3
EST1-7-E Carboxylesterase (cluster #7 Of 7), Eukaryotic 7 1 1 1
Uniprot Swissprot Chembl Description Number Shared
EST2_HUMAN O00748 CHEMBL3180 Carboxylesterase 2, Human 95
FAAH1_RAT P97612 CHEMBL3229 Anandamide Amidohydrolase, Rat 69
FAAH1_HUMAN O00519 CHEMBL2243 Anandamide Amidohydrolase, Human 67
EST1_RABIT P12337 CHEMBL2623 Acyl Coenzyme A:cholesterol Acyltransferase, Rabit 42
FAAH1_MOUSE O08914 CHEMBL3455 Anandamide Amidohydrolase, Mouse 28
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 11
EST1_PIG Q29550 CHEMBL3383 Carboxylesterase, Pig 10
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 6
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 3
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 2
Q95214_RABIT Q95214 CHEMBL6141 Acyl-CoA:cholesterol Acyltransferase, Rabit 2
Q9GPG0_MANSE Q9GPG0 CHEMBL1075266 Juvenile Hormone Esterase, Manse 2
A1ZA98_DROME A1ZA98 CHEMBL4265 CG8425-PA [Drosophila Melanogaster], Drome 1
I23O1_HUMAN P14902 CHEMBL4685 Indoleamine 2,3-dioxygenase, Human 1
NCEH1_HUMAN Q6PIU2 CHEMBL5048 Neutral Cholesterol Ester Hydrolase 1, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
Q91WG0_MOUSE Q91WG0 CHEMBL2217 Carboxylesterase 2, Mouse 1
SOAT1_HUMAN P35610 CHEMBL2782 Acyl Coenzyme A:cholesterol Acyltransferase 1, Human 1
SOAT1_RAT O70536 CHEMBL285 Acyl Coenzyme A:cholesterol Acyltransferase 1, Rat 1
TTHY_HUMAN P02766 CHEMBL3194 Transthyretin, Human 1

Most Common Rings