ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (957)
Reactome (2)
Related By:
Pathway (19)
Organism (2)
Gene (5)
Org. Clust. (7)
ChEMBL (128)
Rings (18)

GABA Receptor Alpha-5 Subunit, Human (957 Compounds)

Swissprot:: GBRA5_HUMAN
Stitch:: GBRA5_HUMAN
UniProt:: P31644
ChEMBL:: CHEMBL5112
Reactome:: REACT_24987; REACT_25387
PDB:: GABRA5

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	957	69	31	18
Binding ≤ 1μM	892	55	26	16
Functional ≤ 10μM	15	5	3	2

Reactome ID	Description	Species
REACT_24987	GABA A receptor activation	Homo sapiens
REACT_25387	Ligand-gated ion channel transport	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
GBRA1_HUMAN	P14867	CHEMBL1962	GABA Receptor Alpha-1 Subunit, Human	788
GBRA2_HUMAN	P47869	CHEMBL4956	GABA Receptor Alpha-2 Subunit, Human	719
GBRA3_HUMAN	P34903	CHEMBL3026	GABA Receptor Alpha-3 Subunit, Human	793
GBRA4_HUMAN	P48169	CHEMBL2472	GABA Receptor Alpha-4 Subunit, Human	329
GBRA6_HUMAN	Q16445	CHEMBL2579	GABA Receptor Alpha-6 Subunit, Human	389
GBRB1_HUMAN	P18505	CHEMBL4558	GABA Receptor Beta-1 Subunit, Human	247
GBRB2_HUMAN	P47870	CHEMBL1920	GABA Receptor Beta-2 Subunit, Human	256
GBRB3_HUMAN	P28472	CHEMBL1847	GABA Receptor Beta-3 Subunit, Human	842
GBRG2_HUMAN	P18507	CHEMBL1788	GABA Receptor Gamma-2 Subunit, Human	848
GBRG3_HUMAN	Q99928	CHEMBL2739	GABA Receptor Gamma-3 Subunit, Human	241
GBRT_HUMAN	Q9UN88	CHEMBL2843	GABA Receptor Theta Subunit, Human	166

Ligand-gated ion channel transport

Uniprot	Swissprot	Chembl	Description	Number Shared
GBRA1_HUMAN	P14867	CHEMBL1962	GABA Receptor Alpha-1 Subunit, Human	788
GBRA2_HUMAN	P47869	CHEMBL4956	GABA Receptor Alpha-2 Subunit, Human	719
GBRA3_HUMAN	P34903	CHEMBL3026	GABA Receptor Alpha-3 Subunit, Human	793
GBRA4_HUMAN	P48169	CHEMBL2472	GABA Receptor Alpha-4 Subunit, Human	329
GBRA6_HUMAN	Q16445	CHEMBL2579	GABA Receptor Alpha-6 Subunit, Human	389
GBRB1_HUMAN	P18505	CHEMBL4558	GABA Receptor Beta-1 Subunit, Human	247
GBRB2_HUMAN	P47870	CHEMBL1920	GABA Receptor Beta-2 Subunit, Human	256
GBRB3_HUMAN	P28472	CHEMBL1847	GABA Receptor Beta-3 Subunit, Human	842
GBRG2_HUMAN	P18507	CHEMBL1788	GABA Receptor Gamma-2 Subunit, Human	848
GBRG3_HUMAN	Q99928	CHEMBL2739	GABA Receptor Gamma-3 Subunit, Human	241
GBRR1_HUMAN	P24046	CHEMBL3561	GABA Receptor Rho-1 Subunit, Human	3
GBRR2_HUMAN	P28476	CHEMBL2375	GABA Receptor Rho-2 Subunit, Human	3
GBRR3_HUMAN	A8MPY1	CHEMBL2394	GABA Receptor Rho-3 Subunit, Human	2
GBRT_HUMAN	Q9UN88	CHEMBL2843	GABA Receptor Theta Subunit, Human	166

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GBRA5_MOUSE	Q8BHJ7	CHEMBL2304	GABA Receptor Alpha-5 Subunit, Mouse	37	3	2	2
GBRA5_RAT	P19969	CHEMBL300	GABA Receptor Alpha-5 Subunit, Rat	189	15	11	7

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GBRA1_HUMAN	P14867	CHEMBL1962	GABA Receptor Alpha-1 Subunit, Human	959	77	35	22
GBRA2_HUMAN	P47869	CHEMBL4956	GABA Receptor Alpha-2 Subunit, Human	835	75	35	22
GBRA3_HUMAN	P34903	CHEMBL3026	GABA Receptor Alpha-3 Subunit, Human	957	72	33	20
GBRA4_HUMAN	P48169	CHEMBL2472	GABA Receptor Alpha-4 Subunit, Human	328	41	24	12
GBRA6_HUMAN	Q16445	CHEMBL2579	GABA Receptor Alpha-6 Subunit, Human	391	48	26	13

Clustered By Gene (0)

Clustered By Organism (7)

Code	Description	Substances	Purchasable	Natural	In Man
GBRA5-1-E	GABA Receptor Alpha-5 Subunit (cluster #1 Of 8), Eukaryotic	830	25	13	8
GBRA5-2-E	GABA Receptor Alpha-5 Subunit (cluster #2 Of 8), Eukaryotic	24	4	4	3
GBRA5-3-E	GABA Receptor Alpha-5 Subunit (cluster #3 Of 8), Eukaryotic	154	16	7	2
GBRA5-4-E	GABA Receptor Alpha-5 Subunit (cluster #4 Of 8), Eukaryotic	3	0	0	0
GBRA5-5-E	GABA Receptor Alpha-5 Subunit (cluster #5 Of 8), Eukaryotic	4	4	1	1
GBRA5-6-E	GABA Receptor Alpha-5 Subunit (cluster #6 Of 8), Eukaryotic	134	30	16	10
GBRA5-7-E	GABA Receptor Alpha-5 Subunit (cluster #7 Of 8), Eukaryotic	30	0	0	0
GBRA5-8-E	GABA Receptor Alpha-5 Subunit (cluster #8 Of 8), Eukaryotic	4	4	1	1

Uniprot	Swissprot	Chembl	Description	Number Shared
GBRG2_HUMAN	P18507	CHEMBL1788	GABA Receptor Gamma-2 Subunit, Human	848
GBRB3_HUMAN	P28472	CHEMBL1847	GABA Receptor Beta-3 Subunit, Human	842
GBRA3_HUMAN	P34903	CHEMBL3026	GABA Receptor Alpha-3 Subunit, Human	793
GBRA1_HUMAN	P14867	CHEMBL1962	GABA Receptor Alpha-1 Subunit, Human	788
GBRA2_HUMAN	P47869	CHEMBL4956	GABA Receptor Alpha-2 Subunit, Human	719
GBRA6_HUMAN	Q16445	CHEMBL2579	GABA Receptor Alpha-6 Subunit, Human	389
GBRA4_HUMAN	P48169	CHEMBL2472	GABA Receptor Alpha-4 Subunit, Human	329
GBRB2_HUMAN	P47870	CHEMBL1920	GABA Receptor Beta-2 Subunit, Human	256
GBRB1_HUMAN	P18505	CHEMBL4558	GABA Receptor Beta-1 Subunit, Human	247
GBRD_HUMAN	O14764	CHEMBL3591	GABA Receptor Delta Subunit, Human	241
GBRE_HUMAN	P78334	CHEMBL4635	GABA Receptor Epsilon Subunit, Human	241
GBRG1_HUMAN	Q8N1C3	CHEMBL4044	GABA Receptor Gamma-1 Subunit, Human	241
GBRG3_HUMAN	Q99928	CHEMBL2739	GABA Receptor Gamma-3 Subunit, Human	241
GBRP_HUMAN	O00591	CHEMBL3506	GABA Receptor Pi Subunit, Human	241
GBRT_HUMAN	Q9UN88	CHEMBL2843	GABA Receptor Theta Subunit, Human	166
Z104301	Z104301	CHEMBL1907607	GABA-A Receptor; Anion Channel	94
GBRA2_RAT	P23576	CHEMBL341	GABA Receptor Alpha-2 Subunit, Rat	56
GBRG2_RAT	P18508	CHEMBL297	GABA Receptor Gamma-2 Subunit, Rat	14
GBRA1_RAT	P62813	CHEMBL343	GABA Receptor Alpha-1 Subunit, Rat	13
GBRA5_RAT	P19969	CHEMBL300	GABA Receptor Alpha-5 Subunit, Rat	12
GBRB2_RAT	P63138	CHEMBL295	GABA Receptor Beta-2 Subunit, Rat	12
GBRA1_BOVIN	P08219	CHEMBL3627	GABA Receptor Alpha-1 Subunit, Bovin	11
GBRA2_BOVIN	P10063	CHEMBL2321	GABA Receptor Alpha-2 Subunit, Bovin	11
GBRA3_BOVIN	P10064	CHEMBL3628	GABA Receptor Alpha-3 Subunit, Bovin	11
GBRA4_BOVIN	P20237	CHEMBL3140	GABA Receptor Alpha-4 Subunit, Bovin	11
GBRB1_BOVIN	P08220	CHEMBL2848	GABA Receptor Beta-1 Subunit, Bovin	11
GBRG2_BOVIN	P22300	CHEMBL5138	GABA Receptor Gamma-2 Subunit, Bovin	11
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	10
GBRB3_RAT	P63079	CHEMBL316	GABA Receptor Beta-3 Subunit, Rat	10
GBRA3_RAT	P20236	CHEMBL328	GABA Receptor Alpha-3 Subunit, Rat	8
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	7
GBRG1_RAT	P23574	CHEMBL296	GABA Receptor Gamma-1 Subunit, Rat	7
GBRA4_RAT	P28471	CHEMBL292	GABA Receptor Alpha-4 Subunit, Rat	6
GBRA6_RAT	P30191	CHEMBL293	GABA Receptor Alpha-6 Subunit, Rat	6
GBRA1_MOUSE	P62812	CHEMBL3139	GABA Receptor Alpha-1 Subunit, Mouse	4
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	3
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	3
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	3
CDK1_HUMAN	P06493	CHEMBL308	Cyclin-dependent Kinase 1, Human	3
CP19A_HUMAN	P11511	CHEMBL1978	Cytochrome P450 19A1, Human	3
GBRB1_RAT	P15431	CHEMBL334	GABA Receptor Beta-1 Subunit, Rat	3
GBRD_RAT	P18506	CHEMBL337	GABA Receptor Delta Subunit, Rat	3
GBRE_RAT	Q9ES14	CHEMBL306	GABA Receptor Epsilon Subunit, Rat	3
GBRR1_HUMAN	P24046	CHEMBL3561	GABA Receptor Rho-1 Subunit, Human	3
GBRR1_RAT	P50572	CHEMBL3588	GABA Receptor Rho-1 Subunit, Rat	3
GBRR2_HUMAN	P28476	CHEMBL2375	GABA Receptor Rho-2 Subunit, Human	3
Q91ZM7_RAT	Q91ZM7	CHEMBL305	GABA Receptor Theta Subunit, Rat	3
XDH_HUMAN	P47989	CHEMBL1929	Xanthine Dehydrogenase, Human	3
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	2
A2AMW3_MOUSE	A2AMW3	CHEMBL3121	GABA Receptor Epsilon Subunit, Mouse	2
ABCG2_HUMAN	Q9UNQ0	CHEMBL5393	ATP-binding Cassette Sub-family G Member 2, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CCNB1_HUMAN	P14635	CHEMBL2412	G2/mitotic-specific Cyclin B1, Human	2
CCNB2_HUMAN	O95067	CHEMBL3723	G2/mitotic-specific Cyclin B2, Human	2
CCNB3_HUMAN	Q8WWL7	CHEMBL3606	G2/mitotic-specific Cyclin B3, Human	2
CDK6_HUMAN	Q00534	CHEMBL2508	Cyclin-dependent Kinase 6, Human	2
CP1B1_HUMAN	Q16678	CHEMBL4878	Cytochrome P450 1B1, Human	2
GBRA2_MOUSE	P26048	CHEMBL2705	GABA Receptor Alpha-2 Subunit, Mouse	2
GBRA3_MOUSE	P26049	CHEMBL3387	GABA Receptor Alpha-3 Subunit, Mouse	2
GBRA4_MOUSE	Q9D6F4	CHEMBL4182	GABA Receptor Alpha-4 Subunit, Mouse	2
GBRA5_MOUSE	Q8BHJ7	CHEMBL2304	GABA Receptor Alpha-5 Subunit, Mouse	2
GBRA6_MOUSE	P16305	CHEMBL4710	GABA Receptor Alpha-6 Subunit, Mouse	2
GBRB1_MOUSE	P50571	CHEMBL2839	GABA Receptor Beta-1 Subunit, Mouse	2
GBRB3_MOUSE	P63080	CHEMBL4231	GABA Receptor Beta-3 Subunit, Mouse	2
GBRD_MOUSE	P22933	CHEMBL3907	GABA Receptor Delta Subunit, Mouse	2
GBRG1_MOUSE	Q9R0Y8	CHEMBL2891	GABA Receptor Gamma-1 Subunit, Mouse	2
GBRG2_MOUSE	P22723	CHEMBL2941	GABA Receptor Gamma-2 Subunit, Mouse	2
GBRG3_MOUSE	P27681	CHEMBL4236	GABA Receptor Gamma-3 Subunit, Mouse	2
GBRG3_RAT	P28473	CHEMBL336	GABA Receptor Gamma-3 Subunit, Rat	2
GBRP_MOUSE	Q8QZW7	CHEMBL2746	GABA Receptor Pi Subunit, Mouse	2
GBRP_RAT	O09028	CHEMBL294	GABA Receptor Pi Subunit, Rat	2
GBRR2_RAT	P47742	CHEMBL2953	GABA Receptor Rho-2 Subunit, Rat	2
GBRR3_HUMAN	A8MPY1	CHEMBL2394	GABA Receptor Rho-3 Subunit, Human	2
GBRT_MOUSE	Q9JLF1	CHEMBL3249	GABA Receptor Theta Subunit, Mouse	2
GSK3A_HUMAN	P49840	CHEMBL2850	Glycogen Synthase Kinase-3 Alpha, Human	2
GSK3B_HUMAN	P49841	CHEMBL262	Glycogen Synthase Kinase-3 Beta, Human	2
TSPO_RAT	P16257	CHEMBL4552	Peripheral-type Benzodiazepine Receptor, Rat	2
Z104291	Z104291	CHEMBL1907597	GABA-A Receptor; GABA-A Site (alpha1/beta2 Interface)	2
Z104294	Z104294	CHEMBL1907600	Cyclin-dependent Kinase 5/CDK5 Activator 1	2
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	2
5HT1D_PIG	P79400	CHEMBL4105	Serotonin 1d (5-HT1d) Receptor, Pig	1
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	1
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	1
AA2BR_RAT	P29276	CHEMBL2592	Adenosine A2b Receptor, Rat	1
ALDR_BOVIN	P16116	CHEMBL3081	Aldose Reductase, Bovin	1
ALDR_HUMAN	P15121	CHEMBL1900	Aldose Reductase, Human	1
ALDR_RAT	P07943	CHEMBL2622	Aldose Reductase, Rat	1
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine Oxidase B, Human	1
BACE1_HUMAN	P56817	CHEMBL4822	Beta-secretase 1, Human	1
BGLR_RAT	P06760	CHEMBL4814	Beta-glucuronidase, Rat	1
CBR1_HUMAN	P16152	CHEMBL5586	Carbonyl Reductase [NADPH] 1, Human	1
CCKAR_RAT	P30551	CHEMBL2871	Cholecystokinin A Receptor, Rat	1
CSK21_HUMAN	P68400	CHEMBL3629	Casein Kinase II Alpha, Human	1
CSK2B_HUMAN	P67870	CHEMBL2358	Casein Kinase II Beta, Human	1
DHB1_HUMAN	P14061	CHEMBL3181	Estradiol 17-beta-dehydrogenase 1, Human	1
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	1
ESR1_HUMAN	P03372	CHEMBL206	Estrogen Receptor Alpha, Human	1
ESR2_HUMAN	Q92731	CHEMBL242	Estrogen Receptor Beta, Human	1
FABPL_RAT	P02692	CHEMBL5738	Fatty Acid-binding Protein, Liver, Rat	1
GABR1_HUMAN	Q9UBS5	CHEMBL2064	GABA-B Receptor 1, Human	1
GABR1_RAT	Q9Z0U4	CHEMBL2753	GABA-B Receptor 1, Rat	1
GABR2_HUMAN	O75899	CHEMBL5034	GABA-B Receptor 2, Human	1
GABR2_RAT	O88871	CHEMBL4686	GABA-B Receptor 2, Rat	1
GASR_RAT	P30553	CHEMBL3508	Cholecystokinin B Receptor, Rat	1
KD4DL_HUMAN	B2RXH2	CHEMBL1293226	Lysine-specific Demethylase 4D-like, Human	1
LOX12_HUMAN	P18054	CHEMBL3687	Arachidonate 12-lipoxygenase, Human	1
LOX15_HUMAN	P16050	CHEMBL2903	Arachidonate 15-lipoxygenase, Human	1
LX12L_RAT	Q02759	CHEMBL2741	Arachidonate 12-lipoxygenase, Rat	1
LX15B_RAT	Q8K4F2	CHEMBL3289	Arachidonate 15-lipoxygenase, Type II, Rat	1
MRP1_HUMAN	P33527	CHEMBL3004	Multidrug Resistance-associated Protein 1, Human	1
NOX4_HUMAN	Q9NPH5	CHEMBL1250375	NADPH Oxidase 4, Human	1
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	1
OPRD_PIG	P79291	CHEMBL4103	Delta Opioid Receptor, Pig	1
P90584_PLAFA	P90584	CHEMBL4090	Protein Kinase Pfmrk, Plafa	1
PDE5A_BOVIN	Q28156	CHEMBL3478	Phosphodiesterase 5A, Bovin	1
PGH2_HUMAN	P35354	CHEMBL230	Cyclooxygenase-2, Human	1
PGH2_MOUSE	Q05769	CHEMBL4321	Cyclooxygenase-2, Mouse	1
Q7ZJM1_9HIV1	Q7ZJM1	CHEMBL3471	Human Immunodeficiency Virus Type 1 Integrase, 9hiv1	1
Q965D6_PLAFA	Q965D6	CHEMBL4513	3-oxoacyl-acyl-carrier Protein Reductase, Plafa	1
S6A11_HUMAN	P48066	CHEMBL5208	GABA Transporter 3, Human	1
S6A11_RAT	P31647	CHEMBL3598	GABA Transporter 3, Rat	1
S6A12_RAT	P48056	CHEMBL5248	Betaine Transporter, Rat	1
S6A13_RAT	P31646	CHEMBL4889	GABA Transporter 2, Rat	1
SC6A1_HUMAN	P30531	CHEMBL1903	GABA Transporter 1, Human	1
SC6A1_RAT	P23978	CHEMBL4054	GABA Transporter 1, Rat	1
XDH_BOVIN	P80457	CHEMBL3649	Xanthine Dehydrogenase, Bovin	1
Z50594	Z50594	CHEMBL375	Mus Musculus	1