UCSF

Glucagon Receptor, Human (503 Compounds)

Swissprot:
GLR_HUMAN
Stitch:
GLR_HUMAN
UniProt:
P47871
ChEMBL:
CHEMBL1985
Reactome:
REACT_18283
REACT_19327
REACT_1665
REACT_18377
PDB:
3CZF (DOCK)
GCGR

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 503 13 0 0
Binding ≤ 1μM 422 7 0 0
Functional ≤ 10μM 116 2 0 0

Reactome Network (4)

Reactome ID Description Species
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_19327 G alpha (s) signalling events Homo sapiens
REACT_1665 Glucagon signaling in metabolic regulation Homo sapiens
REACT_18377 Glucagon-type ligand receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GLUC_HUMAN P01275 CHEMBL5736 Glucagon, Human 6

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 98
GIP_HUMAN P09681 CHEMBL5571 Gastric Inhibitory Polypeptide, Human 8
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 6
GLUC_HUMAN P01275 CHEMBL5736 Glucagon, Human 6
PACR_HUMAN P41586 CHEMBL5399 Pituitary Adenylate Cyclase-activating Polypeptide Type I Receptor, Human 3

Glucagon signaling in metabolic regulation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
GLUC_HUMAN P01275 CHEMBL5736 Glucagon, Human 6

Glucagon-type ligand receptors

Uniprot Swissprot Chembl Description Number Shared
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 98
GIP_HUMAN P09681 CHEMBL5571 Gastric Inhibitory Polypeptide, Human 8
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 6
GLUC_HUMAN P01275 CHEMBL5736 Glucagon, Human 6
PACR_HUMAN P41586 CHEMBL5399 Pituitary Adenylate Cyclase-activating Polypeptide Type I Receptor, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GLR_MOUSE Q61606 CHEMBL4773 Glucagon Receptor, Mouse 35 1 0 0
GLR_RAT P30082 CHEMBL4720 Glucagon Receptor, Rat 15 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GLRA1_HUMAN P23415 CHEMBL5845 Glycine Receptor Subunit Alpha-1, Human 13 2 2 2
GLRA2_HUMAN P23416 CHEMBL5871 Glycine Receptor Subunit Alpha-2, Human 9 2 2 2

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
GLR-1-E Glucagon Receptor (cluster #1 Of 2), Eukaryotic 183 3 0 0
GLR-2-E Glucagon Receptor (cluster #2 Of 2), Eukaryotic 332 10 0 0
Uniprot Swissprot Chembl Description Number Shared
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 94
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 55
GLR_MOUSE Q61606 CHEMBL4773 Glucagon Receptor, Mouse 36
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 25
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 25
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 25
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
GLR_RAT P30082 CHEMBL4720 Glucagon Receptor, Rat 15
Z81011 Z81011 CHEMBL614840 Human Cell Lines 13
GIP_HUMAN P09681 CHEMBL5571 Gastric Inhibitory Polypeptide, Human 8
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 6
GLUC_HUMAN P01275 CHEMBL5736 Glucagon, Human 6
GIPR_RAT P43219 CHEMBL5001 Gastric Inhibitory Polypeptide Receptor, Rat 3
PACR_HUMAN P41586 CHEMBL5399 Pituitary Adenylate Cyclase-activating Polypeptide Type I Receptor, Human 3
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY2_MOUSE Q80TL1 CHEMBL3049 Adenylate Cyclase Type II, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY6_MOUSE Q01341 CHEMBL3015 Adenylate Cyclase Type VI, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 2
MK14_RAT P70618 CHEMBL4825 MAP Kinase P38 Alpha, Rat 2
E2R517_CANFA E2R517 CHEMBL1649060 Uncharacterized Protein, Canine 1

Most Common Rings