ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (161)
Reactome (4)
Related By:
Pathway (11)
Organism (2)
Gene (3)
Org. Clust. (3)
ChEMBL (69)
Rings (20)

Glutamate Receptor Ionotropic, AMPA 1, Human (161 Compounds)

Swissprot:: GRIA1_HUMAN
Stitch:: GRIA1_HUMAN
UniProt:: P42261
ChEMBL:: CHEMBL2009
Reactome:: REACT_18338; REACT_18307; REACT_18422; REACT_20594
PDB:: GRIA1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	161	19	11	13
Binding ≤ 1μM	120	14	7	7
Functional ≤ 10μM	12	8	6	5

Reactome ID	Description	Species
REACT_18338	Activation of AMPA receptors	Homo sapiens
REACT_18307	Trafficking of AMPA receptors	Homo sapiens
REACT_18422	Trafficking of GluR2-containing AMPA receptors	Homo sapiens
REACT_20594	Unblocking of NMDA receptor, glutamate binding and activation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	114
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	99
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	109

Trafficking of AMPA receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	99
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	109

Trafficking of GluR2-containing AMPA receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	114
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	99
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	109

Unblocking of NMDA receptor, glutamate binding and activation

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	114
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	99
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	109
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	3
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	3
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	3
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	3
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	5

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GRIA1_MOUSE	P23818	CHEMBL3502	Glutamate Receptor Ionotropic, AMPA 1, Mouse	567	31	19	19
GRIA1_RAT	P19490	CHEMBL3753	Glutamate Receptor Ionotropic, AMPA 1, Rat	154	22	15	17

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	150	18	9	10
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	100	11	8	6
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	122	18	13	13

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
GRIA1-1-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 4), Eukaryotic	199	21	9	14
GRIA1-2-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic	512	20	8	13
GRIA1-3-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic	30	4	5	4
GRIA1-4-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #4 Of 4), Eukaryotic	75	3	5	0

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	114
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	109
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	99
GRIK5_HUMAN	Q16478	CHEMBL2675	Glutamate Receptor Ionotropic Kainate 5, Human	44
GRIA2_RAT	P19491	CHEMBL3503	Glutamate Receptor Ionotropic, AMPA 2, Rat	42
GRIK1_HUMAN	P39086	CHEMBL1918	Glutamate Receptor Ionotropic Kainate 1, Human	42
GRIA3_RAT	P19492	CHEMBL3504	Glutamate Receptor Ionotropic, AMPA 3, Rat	40
GRIA4_RAT	P19493	CHEMBL3505	Glutamate Receptor Ionotropic, AMPA 4, Rat	38
GRIA1_MOUSE	P23818	CHEMBL3502	Glutamate Receptor Ionotropic, AMPA 1, Mouse	33
GRIA1_RAT	P19490	CHEMBL3753	Glutamate Receptor Ionotropic, AMPA 1, Rat	29
GRIK1_RAT	P22756	CHEMBL2919	Glutamate Receptor Ionotropic Kainate 1, Rat	29
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	29
GRIK3_HUMAN	Q13003	CHEMBL3684	Glutamate Receptor Ionotropic Kainate 3, Human	29
GRIK4_HUMAN	Q16099	CHEMBL2829	Glutamate Receptor Ionotropic Kainate 4, Human	25
GRIK2_RAT	P42260	CHEMBL3607	Glutamate Receptor Ionotropic Kainate 2, Rat	17
GRIK3_RAT	P42264	CHEMBL3744	Glutamate Receptor Ionotropic Kainate 3, Rat	16
GRIK4_RAT	Q01812	CHEMBL3044	Glutamate Receptor Ionotropic Kainate 4, Rat	16
GRIK5_RAT	Q63273	CHEMBL4041	Glutamate Receptor Ionotropic Kainate 5, Rat	16
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	14
NMDZ1_RAT	P35439	CHEMBL330	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	10
GRIA2_MOUSE	P23819	CHEMBL3205	Glutamate Receptor Ionotropic, AMPA 2, Mouse	8
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	8
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	8
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	6
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	5
NMDE1_RAT	Q00959	CHEMBL310	Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat	4
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	3
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	3
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	3
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	3
NMDE2_RAT	Q00960	CHEMBL311	Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat	3
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	3
NMDE3_RAT	Q00961	CHEMBL401	Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat	3
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	3
NMDE4_RAT	Q62645	CHEMBL303	Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat	3
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
GRIK2_XENLA	Q91755	CHEMBL3395	Glutamate Receptor Ionotropic Kainate 2, Xenla	2
GRM1_HUMAN	Q13255	CHEMBL3772	Metabotropic Glutamate Receptor 1, Human	2
GRM1_RAT	P23385	CHEMBL4477	Metabotropic Glutamate Receptor 1, Rat	2
GRM2_HUMAN	Q14416	CHEMBL5137	Metabotropic Glutamate Receptor 2, Human	2
GRM2_RAT	P31421	CHEMBL2851	Metabotropic Glutamate Receptor 2, Rat	2
GRM3_HUMAN	Q14832	CHEMBL2888	Metabotropic Glutamate Receptor 3, Human	2
GRM3_RAT	P31422	CHEMBL3067	Metabotropic Glutamate Receptor 3, Rat	2
GRM4_HUMAN	Q14833	CHEMBL2736	Metabotropic Glutamate Receptor 4, Human	2
GRM5_HUMAN	P41594	CHEMBL3227	Metabotropic Glutamate Receptor 5, Human	2
GRM5_RAT	P31424	CHEMBL2564	Metabotropic Glutamate Receptor 5, Rat	2
GRM8_MOUSE	P47743	CHEMBL4626	Metabotropic Glutamate Receptor 8, Mouse	2
NMD3A_RAT	Q9R1M7	CHEMBL342	Glutamate [NMDA] Receptor Subunit 3A, Rat	2
NMD3B_RAT	Q8VHN2	CHEMBL282	Glutamate [NMDA] Receptor Subunit 3B, Rat	2
EAA3_HUMAN	P43005	CHEMBL2721	Excitatory Amino Acid Transporter 3, Human	1
GLRA1_RAT	P07727	CHEMBL3246	Glycine Receptor Alpha-1 Chain, Rat	1
GLRA2_RAT	P22771	CHEMBL2328	Glycine Receptor Alpha-2 Chain, Rat	1
GLRA3_RAT	P24524	CHEMBL2677	Glycine Receptor Alpha-3 Chain, Rat	1
GLRA4_MOUSE	Q61603	CHEMBL3500	Glycine Receptor Alpha-4 Chain, Mouse	1
GLRB_RAT	P20781	CHEMBL4126	Glycine Receptor Beta Chain, Rat	1
GRM1_MOUSE	P97772	CHEMBL2892	Metabotropic Glutamate Receptor 1, Mouse	1
GRM3_MOUSE	Q9QYS2	CHEMBL3824	Metabotropic Glutamate Receptor 3, Mouse	1
GRM4_RAT	P31423	CHEMBL2787	Metabotropic Glutamate Receptor 4, Rat	1
GRM6_HUMAN	O15303	CHEMBL4573	Metabotropic Glutamate Receptor 6, Human	1
GRM6_RAT	P35349	CHEMBL3842	Metabotropic Glutamate Receptor 6, Rat	1
GRM7_MOUSE	Q68ED2	CHEMBL3966	Metabotropic Glutamate Receptor 7, Mouse	1
GRM8_HUMAN	O00222	CHEMBL3228	Metabotropic Glutamate Receptor 8, Human	1
GRM8_RAT	P70579	CHEMBL2718	Metabotropic Glutamate Receptor 8, Rat	1
MURI_HELPY	P56068	CHEMBL6078	Glutamate Racemase, Helpy	1
Q80T35_MOUSE	Q80T35	CHEMBL3033	Metabotropic Glutamate Receptor 6, Mouse	1
Q80T43_MOUSE	Q80T43	CHEMBL3779	Metabotropic Glutamate Receptor 2, Mouse	1
Q80T47_MOUSE	Q80T47	CHEMBL2832	Metabotropic Glutamate Receptor 5, Mouse	1
Z50466	Z50466	CHEMBL368	Trypanosoma Cruzi	1
Z50594	Z50594	CHEMBL375	Mus Musculus	1