UCSF

Histone Deacetylase 1, Mouse (26 Compounds)

Swissprot:
HDAC1_MOUSE
Stitch:
HDAC1_MOUSE
UniProt:
O09106
ChEMBL:
CHEMBL4001
Reactome:
REACT_196591
REACT_196589
REACT_219771
REACT_220566
REACT_198649
REACT_216539
REACT_199110
REACT_257106
REACT_214440
REACT_200667
REACT_196464
REACT_202086
REACT_233471
REACT_235780
PDB:
Hdac1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 26 3 1 2
Binding ≤ 1μM 21 2 1 2

Reactome Network (14)

Reactome ID Description Species
REACT_196591 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mus musculus
REACT_196589 Constitutive Signaling by NOTCH1 PEST Domain Mutants Mus musculus
REACT_219771 deactivation of the beta-catenin transactivating complex Mus musculus
REACT_220566 Downregulation of SMAD2/3:SMAD4 transcriptional activity Mus musculus
REACT_198649 Factors involved in megakaryocyte development and platelet production Mus musculus
REACT_216539 formation of the beta-catenin:TCF transactivating complex Mus musculus
REACT_199110 G0 and Early G1 Mus musculus
REACT_257106 HDACs deacetylate histones Mus musculus
REACT_214440 NoRC negatively regulates rRNA expression Mus musculus
REACT_200667 NoRC negatively regulates rRNA expression Mus musculus
REACT_196464 NOTCH1 Intracellular Domain Regulates Transcription Mus musculus
REACT_202086 p75NTR negatively regulates cell cycle via SC1 Mus musculus
REACT_233471 repression of WNT target genes Mus musculus
REACT_235780 RNA Polymerase I Transcription Initiation Mus musculus
Uniprot Swissprot Chembl Description Number Shared
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2

Factors involved in megakaryocyte development and platelet production

Uniprot Swissprot Chembl Description Number Shared
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8

HDACs deacetylate histones

Uniprot Swissprot Chembl Description Number Shared
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 10

NoRC negatively regulates rRNA expression

Uniprot Swissprot Chembl Description Number Shared
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8

NoRC negatively regulates rRNA expression

Uniprot Swissprot Chembl Description Number Shared
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2

p75NTR negatively regulates cell cycle via SC1

Uniprot Swissprot Chembl Description Number Shared
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2

RNA Polymerase I Transcription Initiation

Uniprot Swissprot Chembl Description Number Shared
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC1_CHICK P56517 CHEMBL4582 Histone Deacetylase 1, Chick 21 1 1 0
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 1,826 45 16 13
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 76 8 1 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8 1 0 1
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2 1 0 1
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 11 1 0 1
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 40 1 0 1
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2 1 0 1
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 10 1 0 1
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2 1 0 1

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
HDAC1-1-E Histone Deacetylase 1 (cluster #1 Of 4), Eukaryotic 1,131 29 13 8
HDAC1-2-E Histone Deacetylase 1 (cluster #2 Of 4), Eukaryotic 667 10 2 5
HDAC1-3-E Histone Deacetylase 1 (cluster #3 Of 4), Eukaryotic 12 6 1 1
HDAC1-4-E Histone Deacetylase 1 (cluster #4 Of 4), Eukaryotic 98 3 0 0
Uniprot Swissprot Chembl Description Number Shared
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 16
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 16
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 16
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 16
Q94F81_MAIZE Q94F81 CHEMBL4919 Histone Deacetylase HD2, Maize 15
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 11
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 11
Q9ZTP8_MAIZE Q9ZTP8 CHEMBL3541 Histone Deacetylase HD1B, Maize 11
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 10
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 7
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 7
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 7
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 7
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 7
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 7
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 7
B1WBY8_RAT B1WBY8 CHEMBL4705 Histone Deacetylase 2, Rat 3
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 3
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 3
HDAC4_RAT Q99P99 CHEMBL2874 Histone Deacetylase 4, Rat 3
HDAC7_RAT Q99P96 CHEMBL2914 Histone Deacetylase 7, Rat 3
Q5RJZ2_RAT Q5RJZ2 CHEMBL4025 Histone Deacetylase 5, Rat 3
Q99P97_RAT Q99P97 CHEMBL3101 Histone Deacetylase 6, Rat 3
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 2
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2
HDAH_ALCSD Q70I53 CHEMBL6017 Histone Deacetylase-like Amidohydrolase, Alcsd 2
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 2
Q9XYC7_PLAFA Q9XYC7 CHEMBL5541 Histone Deacetylase, Plafa 2
Q7K6A1_PLAF7 Q7K6A1 CHEMBL1293190 Histone Deacetylase, Plaf7 1
SF3B3_HUMAN Q15393 CHEMBL1250378 Splicing Factor 3B Subunit 3, Human 1
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 1