UCSF

Leukocyte Adhesion Glycoprotein LFA-1 Alpha, Human (471 Compounds)

Swissprot:
ITAL_HUMAN
Stitch:
ITAL_HUMAN
UniProt:
P20701
ChEMBL:
CHEMBL1803
Reactome:
REACT_12051
REACT_11152
REACT_13552
PDB:
1CQP (DOCK)
1DGQ (DOCK)
1IJ4 (DOCK)
1LFA (DOCK)
1MJN (DOCK)
1MQ8 (DOCK)
1MQ9 (DOCK)
1MQA (DOCK)
1RD4 (DOCK)
1T0P (DOCK)
1XDD (DOCK)
1XDG (DOCK)
1XUO (DOCK)
1ZON (DOCK)
1ZOO (DOCK)
1ZOP (DOCK)
2ICA (DOCK)
2K8O (DOCK)
2O7N (DOCK)
3BN3 (DOCK)
3BQM (DOCK)
3BQN (DOCK)
3E2M (DOCK)
3EOA (DOCK)
3EOB (DOCK)
3F74 (DOCK)
3F78 (DOCK)
3HI6 (DOCK)
3M6F (DOCK)
3TCX (DOCK)
ITGAL

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 471 24 2 1
Binding ≤ 1μM 399 11 2 1
Functional ≤ 10μM 97 5 1 1
Uniprot Swissprot Chembl Description Number Shared
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 284

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Uniprot Swissprot Chembl Description Number Shared
ICAM1_HUMAN P05362 CHEMBL3070 Intercellular Adhesion Molecule-1, Human 258
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 284

Integrin cell surface interactions

Uniprot Swissprot Chembl Description Number Shared
ICAM1_HUMAN P05362 CHEMBL3070 Intercellular Adhesion Molecule-1, Human 258
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 284
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITAL_MOUSE P24063 CHEMBL1075188 Integrin Alpha-L, Mouse 2 2 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ITAL-1-E Integrin Alpha-L (cluster #1 Of 2), Eukaryotic 475 24 0 1
ITAL-2-E Integrin Alpha-L (cluster #2 Of 2), Eukaryotic 4 0 2 0
Uniprot Swissprot Chembl Description Number Shared
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 284
ICAM1_HUMAN P05362 CHEMBL3070 Intercellular Adhesion Molecule-1, Human 258
Z80185 Z80185 CHEMBL613833 JY (EBV-transformed B-lymphoblastoid Cells) 14
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 11
Z81338 Z81338 CHEMBL614309 T-cells 11
ITAL_MOUSE P24063 CHEMBL1075188 Integrin Alpha-L, Mouse 2
Z80885 Z80885 CHEMBL614507 BEND (Brain Endothelial Cells) 2
HMDH_HUMAN P04035 CHEMBL402 HMG-CoA Reductase, Human 1
STAT3_HUMAN P40763 CHEMBL4026 Signal Transducer And Activator Of Transcription 3, Human 1
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80526 Z80526 CHEMBL612544 SW480 (Colon Adenocarcinoma Cells) 1
Z80952 Z80952 CHEMBL614662 HES 1
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 1