UCSF

MAP Kinase P38 Beta, Mouse (52 Compounds)

Swissprot:
MK11_MOUSE
Stitch:
MK11_MOUSE
UniProt:
Q9WUI1
ChEMBL:
CHEMBL4335
Reactome:
REACT_237946
REACT_205688
REACT_204811
REACT_258600
REACT_243212
REACT_215063
REACT_198696
REACT_211125
REACT_188970
REACT_207601
REACT_257088
PDB:
Mapk11

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 52 0 0 0
Binding ≤ 1μM 51 0 0 0

Reactome Network (11)

Reactome ID Description Species
REACT_237946 activated TAK1 mediates p38 MAPK activation Mus musculus
REACT_205688 Activation of PPARGC1A (PGC-1alpha) by phosphorylation Mus musculus
REACT_204811 Activation of the AP-1 family of transcription factors Mus musculus
REACT_258600 CDO in myogenesis Mus musculus
REACT_243212 DSCAM interactions Mus musculus
REACT_215063 ERK/MAPK targets Mus musculus
REACT_198696 KSRP destabilizes mRNA Mus musculus
REACT_211125 NOD1/2 Signaling Pathway Mus musculus
REACT_188970 Oxidative Stress Induced Senescence Mus musculus
REACT_207601 p38MAPK events Mus musculus
REACT_257088 VEGFA-VEGFR2 Pathway Mus musculus
Uniprot Swissprot Chembl Description Number Shared
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Uniprot Swissprot Chembl Description Number Shared
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

Activation of the AP-1 family of transcription factors

Uniprot Swissprot Chembl Description Number Shared
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

CDO in myogenesis

Uniprot Swissprot Chembl Description Number Shared
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

DSCAM interactions

Uniprot Swissprot Chembl Description Number Shared
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

ERK/MAPK targets

Uniprot Swissprot Chembl Description Number Shared
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

KSRP destabilizes mRNA

Uniprot Swissprot Chembl Description Number Shared
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

NOD1/2 Signaling Pathway

Uniprot Swissprot Chembl Description Number Shared
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

p38MAPK events

Uniprot Swissprot Chembl Description Number Shared
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52

VEGFA-VEGFR2 Pathway

Uniprot Swissprot Chembl Description Number Shared
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 398 30 8 22
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38 0 0 0
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38 0 0 0
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 220 5 1 7

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 52
MK12_MOUSE O08911 CHEMBL2445 MAP Kinase P38 Gamma, Mouse 38
MK13_MOUSE Q9Z1B7 CHEMBL4387 MAP Kinase P38 Delta, Mouse 38
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 1
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1