UCSF

Matrix Metalloproteinase 12, Human (289 Compounds)

Swissprot:
MMP12_HUMAN
Stitch:
MMP12_HUMAN
UniProt:
P39900
ChEMBL:
CHEMBL4393
Reactome:
REACT_150401
REACT_118572
PDB:
1JIZ (DOCK)
1JK3 (DOCK)
1OS2 (DOCK)
1OS9 (DOCK)
1RMZ (DOCK)
1ROS (DOCK)
1UTT (DOCK)
1UTZ (DOCK)
1Y93 (DOCK)
1YCM (DOCK)
1Z3J (DOCK)
2HU6 (DOCK)
2JXY (DOCK)
2K2G (DOCK)
2K9C (DOCK)
2KRJ (DOCK)
2OXU (DOCK)
2OXW (DOCK)
2OXZ (DOCK)
2POJ (DOCK)
2W0D (DOCK)
2WO8 (DOCK)
2WO9 (DOCK)
2WOA (DOCK)
2Z2D (DOCK)
3BA0 (DOCK)
3EHX (DOCK)
3EHY (DOCK)
3F15 (DOCK)
3F16 (DOCK)
3F17 (DOCK)
3F18 (DOCK)
3F19 (DOCK)
3F1A (DOCK)
3LIK (DOCK)
3LIL (DOCK)
3LIR (DOCK)
3LJG (DOCK)
3LK8 (DOCK)
3LKA (DOCK)
3N2U (DOCK)
3N2V (DOCK)
3NX7 (DOCK)
MMP12

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 289 8 4 5
Binding ≤ 1μM 232 7 3 5

Reactome Network (2)

Reactome ID Description Species
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 4
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 13
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 6
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 154
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 73
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 26
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 73
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 126
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 60
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 45
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 83
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 83

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 4
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 2
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 5
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 6
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 154
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 73
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 26
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 73
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 126
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 60
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 45
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 83
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 83
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 16 0 0 1
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 2 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
MMP12-1-E Macrophage Metalloelastase (cluster #1 Of 2), Eukaryotic 264 7 4 6
MMP12-2-E Macrophage Metalloelastase (cluster #2 Of 2), Eukaryotic 42 1 0 0
Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 154
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 126
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 83
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 83
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 73
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 73
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 60
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 46
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 45
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 40
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 26
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 13
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 6
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 6
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 5
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 5
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 4
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 2
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 2
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 2
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 2
Z50264 Z50264 CHEMBL356 Streptococcus Pyogenes 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1

Most Common Rings