UCSF

Nuclear Receptor Corepressor 2, Human (12 Compounds)

Swissprot:
NCOR2_HUMAN
Stitch:
NCOR2_HUMAN
UniProt:
Q9Y618
ChEMBL:
CHEMBL5949
Reactome:
REACT_160254
REACT_160243
REACT_121111
REACT_228222
REACT_118780
REACT_19241
REACT_27161
PDB:
1KKQ (DOCK)
1R2B (DOCK)
1XC5 (DOCK)
2GPV (DOCK)
2L5G (DOCK)
2ODD (DOCK)
3R29 (DOCK)
3R2A (DOCK)
4A69 (DOCK)
NCOR2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 12 3 2 3
Binding ≤ 1μM 11 3 2 3
Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 3
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 3
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 9
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 10
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 5
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 4
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 9
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 5
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 9
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 4

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 3
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 3
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 9
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 10
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 5
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 4
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 9
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 5
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 9
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 4

Downregulation of SMAD2/3:SMAD4 transcriptional activity

Uniprot Swissprot Chembl Description Number Shared
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 9

HDACs deacetylate histones

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 3
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 9
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 10
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 9

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 3
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 3
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 9
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 10
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 5
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 4
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 9
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 5
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 9
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 4

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp

Uniprot Swissprot Chembl Description Number Shared
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12

Transcriptional regulation of white adipocyte differentiation

Uniprot Swissprot Chembl Description Number Shared
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
NCOR2-1-E Nuclear Receptor Corepressor 2 (cluster #1 Of 2), Eukaryotic 8 2 2 2
NCOR2-2-E Nuclear Receptor Corepressor 2 (cluster #2 Of 2), Eukaryotic 4 1 0 1
Uniprot Swissprot Chembl Description Number Shared
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 12
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 10
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 9
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 9
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 9
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 5
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 5
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 4
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 4
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 3
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 3
HDAH_ALCSD Q70I53 CHEMBL6017 Histone Deacetylase-like Amidohydrolase, Alcsd 3
Q9XYC7_PLAFA Q9XYC7 CHEMBL5541 Histone Deacetylase, Plafa 3
B1WBY8_RAT B1WBY8 CHEMBL4705 Histone Deacetylase 2, Rat 2
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 2
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 2
HDAC4_RAT Q99P99 CHEMBL2874 Histone Deacetylase 4, Rat 2
HDAC7_RAT Q99P96 CHEMBL2914 Histone Deacetylase 7, Rat 2
Q5RJZ2_RAT Q5RJZ2 CHEMBL4025 Histone Deacetylase 5, Rat 2
Q94F81_MAIZE Q94F81 CHEMBL4919 Histone Deacetylase HD2, Maize 2
Q99P97_RAT Q99P97 CHEMBL3101 Histone Deacetylase 6, Rat 2
Q9ZTP8_MAIZE Q9ZTP8 CHEMBL3541 Histone Deacetylase HD1B, Maize 2
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 2
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 1
HDAC1_CHICK P56517 CHEMBL4582 Histone Deacetylase 1, Chick 1
HDAC2_CHICK P56519 CHEMBL4583 Histone Deacetylase 2, Chick 1
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 1
HDAC3_CHICK P56520 CHEMBL4584 Histone Deacetylase 3, Chick 1
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 1
HDAC4_CHICK P83038 CHEMBL5599 Histone Deacetylase 4, Chick 1
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 1
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 1
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 1
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 1
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 1
Q7K6A1_PLAF7 Q7K6A1 CHEMBL1293190 Histone Deacetylase, Plaf7 1
Q7YY07_CRYPV Q7YY07 CHEMBL4740 Histone Deacetylase, Crypv 1
Q7YY76_CRYPV Q7YY76 CHEMBL3626 Histone Deacetylase, Crypv 1
SF3B3_HUMAN Q15393 CHEMBL1250378 Splicing Factor 3B Subunit 3, Human 1